Evaluation of the NRF1-proteasome axis as a therapeutic target in breast cancer.

Autor: Byers HA; Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Brooks AN; Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Vangala JR; Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Grible JM; Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Feygin A; Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Clevenger CV; Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Harrell JC; Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Radhakrishnan SK; Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA. senthil.radhakrishnan@vcuhealth.org.

Publikováno v: Scientific reports [Sci Rep] 2023 Sep 22; Vol. 13 (1), pp. 15843. Date of Electronic Publication: 2023 Sep 22.

Publisher Correction: Rewiring of the 3D genome during acquisition of carboplatin resistance in a triple-negative breast cancer patient-derived xenograft.

Autor: Dozmorov MG; Department of Biostatistics, Virginia Commonwealth University, Richmond, VA, 23298, USA. Mikhail.Dozmorov@vcuhealth.org.; Department of Pathology, Virginia Commonwealth University, Richmond, VA, 23284, USA. Mikhail.Dozmorov@vcuhealth.org., Marshall MA; Department of Biostatistics, Virginia Commonwealth University, Richmond, VA, 23298, USA., Rashid NS; Department of Pathology, Virginia Commonwealth University, Richmond, VA, 23284, USA.; Department of Biology, University of Richmond, Richmond, VA, 23173, USA., Grible JM; Department of Pathology, Virginia Commonwealth University, Richmond, VA, 23284, USA., Valentine A; Department of Pathology, Virginia Commonwealth University, Richmond, VA, 23284, USA.; Department of Biochemistry, Virginia Commonwealth University, Richmond, VA, 23284, USA., Olex AL; C. Kenneth and Dianne Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA, 23298, USA., Murthy K; Center for Cancer Immunotherapy and Autoimmunity, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA., Chakraborty A; Center for Cancer Immunotherapy and Autoimmunity, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA., Reyna J; Center for Cancer Immunotherapy and Autoimmunity, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA., Figueroa DS; Center for Cancer Immunotherapy and Autoimmunity, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA., Hinojosa-Gonzalez L; Center for Cancer Immunotherapy and Autoimmunity, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA., Da-Inn Lee E; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, 53792, USA., Baur BA; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, 53792, USA., Roy S; Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA.; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, 53792, USA., Ay F; Center for Cancer Immunotherapy and Autoimmunity, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA.; Department of Pediatrics, UC San Diego-School of Medicine, La Jolla, CA, 92093, USA., Harrell JC; Department of Pathology, Virginia Commonwealth University, Richmond, VA, 23284, USA. Joshua.Harrell@vcuhealth.org.

Publikováno v: Scientific reports [Sci Rep] 2023 May 09; Vol. 13 (1), pp. 7522. Date of Electronic Publication: 2023 May 09.

Discovering Synergistic Compounds with BYL-719 in PI3K Overactivated Basal-like PDXs.

Autor: Boyd DC; Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298, USA.; Integrative Life Sciences Program, Virginia Commonwealth University, Richmond, VA 23284, USA., Zboril EK; Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298, USA., Olex AL; C. Kenneth and Dianne Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA 23298, USA., Leftwich TJ; Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298, USA., Hairr NS; Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298, USA., Byers HA; Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298, USA., Valentine AD; Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298, USA., Altman JE; Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298, USA., Alzubi MA; Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298, USA.; Integrative Life Sciences Program, Virginia Commonwealth University, Richmond, VA 23284, USA., Grible JM; Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298, USA., Turner SA; Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298, USA., Ferreira-Gonzalez A; Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298, USA., Dozmorov MG; Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298, USA.; Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23219, USA., Harrell JC; Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298, USA.; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.

Publikováno v: Cancers [Cancers (Basel)] 2023 Mar 03; Vol. 15 (5). Date of Electronic Publication: 2023 Mar 03.

Identification of nuclear export inhibitor-based combination therapies in preclinical models of triple-negative breast cancer.

Autor: Rashid NS; Department of Pathology, School of Medicine, Virginia Commonwealth University, 1101 East Marshall St, Office 4-007, P.O. Box 980662, Richmond, VA 23298-0662, USA; Department of Biology, University of Richmond, Richmond, VA USA., Hairr NS; Department of Pathology, School of Medicine, Virginia Commonwealth University, 1101 East Marshall St, Office 4-007, P.O. Box 980662, Richmond, VA 23298-0662, USA., Murray G; C. Kenneth and Diane Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA USA., Olex AL; C. Kenneth and Diane Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA USA., Leftwich TJ; Department of Pathology, School of Medicine, Virginia Commonwealth University, 1101 East Marshall St, Office 4-007, P.O. Box 980662, Richmond, VA 23298-0662, USA., Grible JM; Department of Pathology, School of Medicine, Virginia Commonwealth University, 1101 East Marshall St, Office 4-007, P.O. Box 980662, Richmond, VA 23298-0662, USA., Reed J; C. Kenneth and Diane Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA USA; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA USA; Department of Physics, Virginia Commonwealth University, Richmond, VA USA., Dozmorov MG; Department of Pathology, School of Medicine, Virginia Commonwealth University, 1101 East Marshall St, Office 4-007, P.O. Box 980662, Richmond, VA 23298-0662, USA; Department of Biostatistics, Virginia Commonwealth University, Richmond, VA USA., Harrell JC; Department of Pathology, School of Medicine, Virginia Commonwealth University, 1101 East Marshall St, Office 4-007, P.O. Box 980662, Richmond, VA 23298-0662, USA; C. Kenneth and Diane Wright Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA USA; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA USA. Electronic address: Joshua.Harrell@vcuhealth.org.

Publikováno v: Translational oncology [Transl Oncol] 2021 Dec; Vol. 14 (12), pp. 101235. Date of Electronic Publication: 2021 Oct 07.

Breast cancer liver metastasis: current and future treatment approaches.

Autor: Rashid NS; Department of Pathology, Virginia Commonwealth University, Richmond, VA, 23298, USA., Grible JM; Department of Pathology, Virginia Commonwealth University, Richmond, VA, 23298, USA., Clevenger CV; Department of Pathology, Virginia Commonwealth University, Richmond, VA, 23298, USA.; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, USA., Harrell JC; Department of Pathology, Virginia Commonwealth University, Richmond, VA, 23298, USA. Joshua.Harrell@vcuhealth.org.; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, USA. Joshua.Harrell@vcuhealth.org.

Publikováno v: Clinical & experimental metastasis [Clin Exp Metastasis] 2021 Jun; Vol. 38 (3), pp. 263-277. Date of Electronic Publication: 2021 Mar 06.