Benzimidazole-containing HCV NS5A inhibitors: effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency.

Autor: Henderson JA; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA. Electronic address: james_henderson@vrtx.com., Bilimoria D; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Bubenik M; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Cadilhac C; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Cottrell KM; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Dietrich E; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Denis F; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Ewing N; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Falardeau G; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Giroux S; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Grey R Jr; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., L'Heureux L; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Liu B; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Mani N; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Morris M; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Nicolas O; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Pereira OZ; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Poisson C; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Govinda Rao B; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Reddy TJ; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Selliah S; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Shawgo RS; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Vaillancourt L; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Wang J; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Yannopoulos CG; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Chauret N; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Berlioz-Seux F; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Chan LC; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Das SK; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Grillot AL; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Bennani YL; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Maxwell JP; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Feb 15; Vol. 25 (4), pp. 944-7. Date of Electronic Publication: 2014 Dec 20.