Zobrazeno 1 - 10
of 263
pro vyhledávání: '"Grevelding P"'
Autor:
Tim A Dannenhaus, Franziska Winkelmann, Cindy Reinholdt, Miriam Bischofsberger, Jan Dvořák, Christoph G Grevelding, Micha Löbermann, Emil C Reisinger, Martina Sombetzki
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 10, p e0012615 (2024)
BackgroundSchistosoma mansoni was introduced from Africa to the Americas during the transatlantic slave trade and remains a major public health problem in parts of South America and the Caribbean. This study presents a comprehensive comparative analy
Externí odkaz:
https://doaj.org/article/5664e23471164957a6a581023dd547d8
Autor:
Verena von Bülow, Maryam Schneider, Dorothee Dreizler, Lena Russ, Anne Baier, Nicola Buss, Jakob Lichtenberger, Lukas Härle, Heike Müller, Annette Tschuschner, Gabriele Schramm, Jörn Pons-Kühnemann, Christoph G. Grevelding, Elke Roeb, Martin Roderfeld
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 1, Pp 107-117 (2024)
Background & Aims: Schistosomiasis is one of the most prominent parasite-induced infectious diseases, affecting more than 250 million people. Schistosoma mansoni causes metabolic exhaustion and a strong redox imbalance in the liver, causing parenchym
Externí odkaz:
https://doaj.org/article/03b592b3094a49659ed5de0bf1d43345
Autor:
Lukas Härle, Verena von Bülow, Lukas Knedla, Frederik Stettler, Heike Müller, Daniel Zahner, Simone Haeberlein, Anita Windhorst, Annette Tschuschner, Monika Burg-Roderfeld, Kernt Köhler, Christoph G. Grevelding, Elke Roeb, Martin Roderfeld
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Schistosomiasis is a parasitic disease affecting more than 250 million people worldwide. The transcription factor c-Jun, which is induced in S. mansoni infection-associated liver disease, can promote hepatocyte survival but can also trigger
Externí odkaz:
https://doaj.org/article/85d43555af414192a45ae30b4e1cfbfb
Autor:
Heike Müller, Jan K. Straßmann, Anne S. Baier, Verena von Bülow, Frederik Stettler, Maximilian J. Hagen, Fabian P. Schmidt, Annette Tschuschner, Andreas R. Schmid, Daniel Zahner, Kernt Köhler, Jörn Pons-Kühnemann, Daniel Leufkens, Dieter Glebe, Surmeet Kaur, Max F. Möscheid, Simone Haeberlein, Christoph G. Grevelding, Ralf Weiskirchen, Mohamed El-Kassas, Khaled Zalata, Elke Roeb, Martin Roderfeld
Publikováno v:
Cells, Vol 13, Iss 19, p 1643 (2024)
Schistosomiasis affects over 250 million people worldwide, with the highest prevalence at the age of 10–14 years. The influence of the host’s age on the severity of liver damage is unclear. We infected male 8, 14, and 20-week-old mice with S. man
Externí odkaz:
https://doaj.org/article/7fb650e6fac343df8883926123b51846
Autor:
Lena Russ, Verena von Bülow, Sarah Wrobel, Frederik Stettler, Gabriele Schramm, Franco H. Falcone, Christoph G. Grevelding, Martin Roderfeld, Elke Roeb
Publikováno v:
Cells, Vol 13, Iss 18, p 1579 (2024)
Schistosomiasis, a parasitic disease caused by Schistosoma spp., affects more than 250 million people worldwide. S. mansoni in particular affects the gastrointestinal tract and, through its eggs, induces a Th2 immune response leading to granuloma for
Externí odkaz:
https://doaj.org/article/d1c40398bf9f44c1a09e5e41c1422a8c
Autor:
Bernardo P. Moreira, Sandra G. Gava, Simone Haeberlein, Sophie Gueye, Ester S. S. Santos, Michael H. W. Weber, Tigran M. Abramyan, Christoph G. Grevelding, Marina M. Mourão, Franco H. Falcone
Publikováno v:
Frontiers in Parasitology, Vol 3 (2024)
IntroductionSchistosomiasis has for many years relied on a single drug, praziquantel (PZQ) for treatment of the disease. Immense efforts have been invested in the discovery of protein kinase (PK) inhibitors; however, given that the majority of PKs ar
Externí odkaz:
https://doaj.org/article/080be4b1e91b4e59a075ffc81f851067
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Max F. Moescheid, Oliver Puckelwaldt, Mandy Beutler, Simone Haeberlein, Christoph G. Grevelding
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract In parasites such as Schistosoma mansoni, gene knockdown by RNA interference (RNAi) has become an indispensable tool for functional gene characterization. To distinguish target-specific RNAi effects versus off-target effects, controls are es
Externí odkaz:
https://doaj.org/article/5f732fe8699c4ff9a735b8a912cb1064
Autor:
Wiebke Obermann, Mohammad Farhan Darin Azri, Leonie Konopka, Nina Schmidt, Francesca Magari, Julian Sherman, Liliana M. R. Silva, Carlos Hermosilla, Andreas H. Ludewig, Hicham Houhou, Simone Haeberlein, Mona Yiting Luo, Irina Häcker, Marc F. Schetelig, Christoph G. Grevelding, Frank C. Schroeder, Gilbert Sei Kung Lau, Anja Taubert, Ana Rodriguez, Andreas Heine, Tiong Chia Yeo, Arnold Grünweller, Gaspar Taroncher-Oldenburg
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Inhibition of eukaryotic initiation factor 4A has been proposed as a strategy to fight pathogens. Rocaglates exhibit the highest specificities among eIF4A inhibitors, but their anti-pathogenic potential has not been comprehensively assessed
Externí odkaz:
https://doaj.org/article/8922ae7cbaff49e69d1bb970b63c9468
Autor:
Xuesong Li, Oliver Weth, Martin Haimann, Max F. Möscheid, Theresa S. Huber, Christoph G. Grevelding
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT Schistosomes are parasitic flatworms that cause schistosomiasis, a neglected tropical disease of worldwide importance. Since standard treatment of schistosomiasis relies on a single drug, praziquantel, alternative drugs are needed. G protein
Externí odkaz:
https://doaj.org/article/e3ef3602c3494102b4fac54d05c887ac