Droplet digital PCR-based testing for donor-derived cell-free DNA in transplanted patients as noninvasive marker of allograft health: Methodological aspects.

Autor: Frederik Banch Clausen, Kristine Mathilde Clara Lund Jørgensen, Lasse Witt Wardil, Leif Kofoed Nielsen, Grethe Risum Krog

Publikováno v: PLoS ONE, Vol 18, Iss 2, p e0282332 (2023)

In solid organ transplantation, donor-derived cell-free DNA (dd-cfDNA) is a promising universal noninvasive biomarker for allograft health, where high levels of dd-cfDNA indicate organ damage. Using Droplet Digital PCR (ddPCR), we aimed to develop an

Externí odkaz: https://doaj.org/article/090327ec41b4476180b1e1b4df73a198

Prediction of ABO hemolytic disease of the newborn using pre- and perinatal quantification of maternal anti-A/anti-B IgG titer

Autor: Bo Mølholm Hansen, Thomas Bergholt, Anette Kjærbye-Thygesen, Mette Line Donneborg, Finn Ebbesen, Morten Hanefeld Dziegiel, Per Albertsen, Grethe Risum Krog, Mette Kiel Smed, Kristian Vestergaard Jensen, Frederik Banch Clausen, Henriette Lorenzen

Publikováno v: Krog, G R, Donneborg, M L, Hansen, B M, Lorenzen, H, Clausen, F B, Jensen, K V, Kjærbye-Thygesen, A, Albertsen, P, Ebbesen, F, Bergholt, T, Smed, M K & Dziegiel, M H 2021, ' Prediction of ABO hemolytic disease of the newborn using pre-and perinatal quantification of maternal anti-A/anti-B IgG titer ', Pediatric Research, vol. 90, no. 1, pp. 74-81 . https://doi.org/10.1038/s41390-020-01232-5

Background: Hemolysis in fetus/newborns is often caused by maternal antibodies. There are currently no established screening procedures for maternal ABO antibodies harmful to fetus/newborn. We investigated the clinical significance, and predictive va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e380168fbf057166c00a595ab3d057
https://doi.org/10.1038/s41390-020-01232-5

Pre-analytical conditions in non-invasive prenatal testing of cell-free fetal RHD.

Autor: Frederik Banch Clausen, Tanja Roien Jakobsen, Klaus Rieneck, Grethe Risum Krog, Leif Kofoed Nielsen, Ann Tabor, Morten Hanefeld Dziegiel

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e76990 (2013)

BackgroundNon-invasive prenatal testing of cell-free fetal DNA (cffDNA) in maternal plasma can predict the fetal RhD type in D negative pregnant women. In Denmark, routine antenatal screening for the fetal RhD gene (RHD) directs the administration of

Externí odkaz: https://doaj.org/article/4d8020cb73d04282ae8f0ac71386cb08

Noninvasive Antenatal Screening for Fetal RHD in RhD Negative Women to Guide Targeted Anti-D Prophylaxis

Autor: Klaus Rieneck, Birgitte Suhr Bundgaard, Grethe Risum Krog, Morten Hanefeld Dziegiel, Frederik Banch Clausen

Publikováno v: Prenatal Diagnosis ISBN: 9781493988877

RhD negative pregnant women who carry an RhD positive fetus are at risk of immunization against the D antigen, which may result in hemolytic disease of the fetus and the newborn. Predicting the fetal RhD status by noninvasive antenatal screening for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f75b2de17b61f5d8f087c233d978632a
https://doi.org/10.1007/978-1-4939-8889-1_23

Routine noninvasive prenatal screening for fetalRHDin plasma of RhD-negative pregnant women-2 years of screening experience from Denmark

Autor: Morten Hanefeld Dziegiel, F. Banch Clausen, Marianne Antonius Jakobsen, Rudi Steffensen, Rikke Dyhrberg Madsen, M Rudby, Ulrik Sprogøe, Grethe Risum Krog, Tanja Roien Jakobsen, John Bæch, Mette Christiansen, Kaspar René Nielsen, Klaus Rieneck, N Grunnet, Keld Mikkelsen Homburg

Publikováno v: Prenatal Diagnosis. 34:1000-1005

Objective Prenatal and postnatal RhD prophylaxis reduces the risk of RhD immunization in pregnancies of RhDnegative women. Based on the result from prenatal screening for the fetal RHD gene, prenatal RhD prophylaxis in Denmark is targeted to RhD-nega

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b2c01b57d398faf8568689f8b7318ca
https://doi.org/10.1002/pd.4419