Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Grethe Bergseth"'
Autor:
Corinna Lau, Martin Berner McAdam, Grethe Bergseth, Algirdas Grevys, Jack Ansgar Bruun, Judith Krey Ludviksen, Hilde Fure, Terje Espevik, Anders Moen, Jan Terje Andersen, Tom Eirik Mollnes
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
The mechanism of action of recombinant IgG2/4 antibodies involves blocking of their target without the induction of effector functions. Examples are eculizumab (Soliris®), which is used clinically to block complement factor C5, as well as anti-human
Externí odkaz:
https://doaj.org/article/47db5db76b9b495db2e11d3842a8dff3
Autor:
Anna Bjerre, Grethe Bergseth, Judith Krey Ludviksen, Arne Stokke, Vidar Bosnes, Diana Karpman, Tom Eirik Mollnes
Publikováno v:
Case Reports in Nephrology, Vol 2018 (2018)
We report a pediatric patient with atypical hemolytic uremic syndrome due to a C3 gain-of-function mutation diagnosed in infancy. She was treated from the start with a constant dose of 300 mg eculizumab every second week from the onset and followed b
Externí odkaz:
https://doaj.org/article/94b63ca5bae6403a924913a3b89a2def
Autor:
Dorte Christiansen, Grethe Bergseth, S. Nymo, Terje Espevik, Tom Eirik Mollnes, Knut Tore Lappegård, J. Krey Ludviksen, Ole-Lars Brekke, Trent M. Woodruff, Anne Landsem, Hilde Fure, Corinna Lau, M. Mathisen
Publikováno v:
Clinical and Experimental Immunology
There is a close cross‐talk between complement, Toll‐like receptors (TLRs) and coagulation. The role of the central complement component 5 (C5) in physiological and pathophysiological hemostasis has not, however, been fully elucidated. This study
Autor:
Jean M. H. van den Elsen, Camilla Schjalm, Ole-Lars Brekke, Tom Eirik Mollnes, Soeren Erik Pischke, Grethe Bergseth, Oliver Durrant, Linda M. Haugaard-Kedström, Anne Landsem, Alex Macpherson, Quang Huy Quach, Per H. Nilsson, Hilde Fure, Markus Huber-Lang, Christina Johnson
Publikováno v:
J Immunol
Journal of Immunology
Nilsson, P H, Johnson, C, Quach, Q H, Macpherson, A, Durrant, O, Pischke, S E, Fure, H, Landsem, A, Bergseth, G, Schjalm, C, Haugaard-Kedström, L M, Huber-Lang, M, van den Elsen, J, Brekke, O L & Mollnes, T E 2021, ' A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity ', Journal of Immunology, vol. 207, no. 6, pp. 1641-1651 . https://doi.org/10.4049/jimmunol.2001471
Journal of Immunology
Nilsson, P H, Johnson, C, Quach, Q H, Macpherson, A, Durrant, O, Pischke, S E, Fure, H, Landsem, A, Bergseth, G, Schjalm, C, Haugaard-Kedström, L M, Huber-Lang, M, van den Elsen, J, Brekke, O L & Mollnes, T E 2021, ' A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity ', Journal of Immunology, vol. 207, no. 6, pp. 1641-1651 . https://doi.org/10.4049/jimmunol.2001471
Thrombin activation of C5 connects thrombosis to inflammation. Complement research in whole blood ex vivo necessitates anticoagulation, which potentially interferes with the inflammatory modulation by thrombin. We challenged the concept of thrombin a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b448dc19a64a17108672b963fe184bed
http://hdl.handle.net/10852/88977
http://hdl.handle.net/10852/88977
Autor:
Grethe Bergseth, Jan Terje Andersen, Tom Eirik Mollnes, Corinna Lau, Judith K Ludviksen, Martin Berner McAdam, Terje Espevik, Algirdas Grevys, Hilde Fure, Anders Moen, Jack-Ansgar Bruun
Publikováno v:
mAbs
The mechanism of action of recombinant IgG2/4 antibodies involves blocking of their target without the induction of effector functions. Examples are eculizumab (Soliris®), which is used clinically to block complement factor C5, as well as anti-human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a59905edc4cbe44dd824bc727437434
https://hdl.handle.net/10037/17237
https://hdl.handle.net/10037/17237
Autor:
Jack F.M. Wetzels, Tom Eirik Mollnes, Lambertus P. van den Heuvel, Dineke Westra, Elena B. Volokhina, Grethe Bergseth, Nicole C. A. J. van de Kar, Thea J A M van der Velden
Publikováno v:
Clinical Immunology
Clinical Immunology, 160, 237-43
Clinical Immunology, 160, 2, pp. 237-43
Clinical Immunology, 160, 237-43
Clinical Immunology, 160, 2, pp. 237-43
Complement C5 inhibitor eculizumab treatment in atypical hemolytic uremic syndrome is effective, but associated with high costs. Complement inhibition monitoring in these patients has not been standardized. In this study we evaluated novel functional
Autor:
Bjørg Lorentzen, Grethe Bergseth, Lillemor Skattum, Vidar Bosnes, Alice Gustavsen, Tom Eirik Mollnes, Yngvar Fløisand, Andreas Barratt-Due
Publikováno v:
Medicine
Rationale: Antiphospholipid syndrome (APS) in pregnancy may trigger the life-threatening catastrophic antiphospholipid syndrome (CAPS). Complement activation is implicated in the pathogenesis, and inhibition of complement factor C5 is suggested as an
Autor:
Andreas Baratt-Due, Søren Erik Pischke, Miles A. Nunn, Albert Castellheim, Grethe Bergseth, Knut Dybwik, Petter Brandtzaeg, Hilde Lang Orrem, Dorte Christiansen, Corinna Lau, Bernt Christian Hellerud, Hilde Fure, Tom Eirik Mollnes, Terje Espevik, Erik Waage Nielsen
Publikováno v:
5:21
Journal of Intensive Care
Journal of Intensive Care
Background Fulminant meningococcal sepsis, characterized by overwhelming innate immune activation, mostly affects young people and causes high mortality. This study aimed to investigate the effect of targeting two key molecules of innate immunity, co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbb02b76414c53efb466e575ac2363e
http://hdl.handle.net/10852/54120
http://hdl.handle.net/10852/54120
Autor:
Tom Eirik Mollnes, Linda M. Haugaard-Kedström, Hilde Fure, Markus Huber-Lang, Anne Landsem, Christina Johnson, Søren Erik Pischke, Grethe Bergseth, Per H. Nilsson, Ole-Lars Brekke
Publikováno v:
Molecular Immunology. 89:136-137
Characterization of a novel whole blood model for the study of thrombin in complement activation and inflammation
Autor:
Petter Brandtzaeg, Dorte Christiansen, Bernt Christian Hellerud, Julie Katrine Lindstad, Ole-Lars Brekke, John D. Lambris, Graham Leslie, Grethe Bergseth, Albert Castellheim, Tom Eirik Mollnes, Erik Waage Nielsen, Hilde Fure, Anne Pharo
Publikováno v:
Brekke, O L, Hellerud, B C, Christiansen, D, Fure, H, Castellheim, A, Nielsen, E W, Pharo, A, Lindstad, J K, Bergseth, G, Leslie, G, Lambris, J D, Brandtzaeg, P & Mollnes, T E 2011, ' Neisseria meningitidis and Escherichia coli are protected from leukocyte phagocytosis by binding to erythrocyte complement receptor 1 in human blood ', Molecular Immunology, vol. 48, no. 15-16, pp. 2159-2169 . https://doi.org/10.1016/j.molimm.2011.07.011
The initial interaction of Gram-negative bacteria with erythrocytes and its implications on leukocyte phagocytosis and oxidative burst in human whole blood were examined. Alexa-labeled Escherichia coli, wild-type H44/76 N. meningitidis and the H44/76