Výsledky vyhledávání - "Grete Sonderstrup-McDevitt"

Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(α1*0101,β1*0401) transgenic mice

Autor: Diane Wherrett, Lars Fugger, Grete Sonderstrup-McDevitt, Andrew P. Cope, Mauro Congia, Eugene Kim, Teddy T. Chen, Salil D. Patel

Publikováno v: Proceedings of the National Academy of Sciences. 94:8082-8087

Glutamic acid decarboxylase isoform 2 (GAD65; EC 4.1.1.15 ) has been identified as a key target autoantigen of insulin-dependent diabetes mellitus (IDDM). IDDM is genetically associated with the major histocompatibility complex (MHC), and particular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a964ae54f26f35bf5b012dd395f3952d
https://doi.org/10.1073/pnas.94.15.8082

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Definition of MHC and T cell receptor contacts in the HLA-DR4restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice

Autor: Lars Fugger, Claus B. Andersen, Rikard Holmdahl, Ellen Christina Andersson, Vivianne Malmström, Helle Jacobsen, Lars S. Madsen, Jonathan B. Rothbard, Bjarke E. Hansen, Grete Sonderstrup McDevitt, Arne Svejgaard, Jan Engberg

Rheumatoid arthritis (RA) is an autoimmune disease associated with the HLA-DR4 and DR1 alleles. The target autoantigen(s) in RA is unknown, but type II collagen (CII) is a candidate, and the DR4- and DR1-restricted immunodominant T cell epitope in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76206ddbe57d1af0c198f6432864bb26
https://europepmc.org/articles/PMC22687/

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Specificity of an HLA-DRB1*0401-restricted T cell response to type II collagen

Autor: Grete Sonderstrup-McDevitt, Jonathan B. Rothbard, Lars Fugger

Publikováno v: European journal of immunology. 26(4)

A panel of HLA-DRB1*0401-restricted CD4+ mouse T cell hybridomas specific for bovine type II collagen were generated from transgenic mice expressing the human HLA-DRA1*0101/-DRB1*0401 and CD4 molecules. The vast majority recognized a single peptide d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02990cd33d037614d31e8d846cf9c352
https://pubmed.ncbi.nlm.nih.gov/8625990

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Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T-cell repertoire and mediates an HLA-DR-restricted immune response

Autor: Ingrid C. Rulifson, Sara A. Michie, Christopher Lock, Lars Fugger, Grete Sonderstrup McDevitt

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 91(13)

Inherited susceptibility to rheumatoid arthritis is associated with genes encoding the human major histocompatibility complex class II molecule HLA-DR4. To study the immune function of HLA-DR4 and attempt to generate a murine model of rheumatoid arth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bad982d3288240380ed27bd6f3e3632
https://pubmed.ncbi.nlm.nih.gov/8016129

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Identification of immunodominant T-cell epitopes of human glutamic acid decarboxylase 65 using HLA-DR4 transgenic mice

Autor: Andrew P. Cope, Salil D. Patel, Grete Sonderstrup-McDevitt, Lars Fugger, Sarrah Parry, Mauro Congia

Publikováno v: Experimental and Clinical Endocrinology & Diabetes. 105:49-49

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0da572dea150d231128e2c50571cbbc3
https://doi.org/10.1055/s-0029-1211868

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