Výsledky vyhledávání - "Grete Hoffmann"

Investigation of phase II metabolism of 11-hydroxy-Δ-9-tetrahydrocannabinol and metabolite verification by chemical synthesis of 11-hydroxy-Δ-9-tetrahydrocannabinol-glucuronide

Autor: Florian Clausen, Jennifer Schürenkamp, Armido Studer, Grete Hoffmann, Christoph Hassenberg

Publikováno v: International Journal of Legal Medicine

(−)-Δ-9-tetrahydrocannabinol ((−)-Δ-9-THC) is the main psychoactive constituent in cannabis. During phase I metabolism, it is metabolized to (−)-11-hydroxy-Δ-9-tetrahydrocannabinol ((−)-11-OH-Δ-9-THC), which is psychoactive, and to (−)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe6668b983323f86a9e01698f04b2ac
https://doi.org/10.1007/s00414-020-02387-w

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Synthesis of Para (−)-Δ8-THC Triflate as a Building Block for the Preparation of THC Derivatives Bearing Different Side Chains

Autor: Constantin G. Daniliuc, Grete Hoffmann, Armido Studer

Publikováno v: Organic Letters. 21:563-566

A two-step synthesis of para (−)-Δ8-THC-OTf that can be used as building block for late-stage introduction of side chains to the tetrahydrodibenzopyran core of THC by cross-coupling chemistry is presented. No protecting groups are needed, and (−

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f39dae2b9a77831ed92fc30c5d5c23b
https://doi.org/10.1021/acs.orglett.8b03907

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Short and Protecting-Group-Free Approach to the (−)-Δ8-THC-Motif: Synthesis of THC-Analogues, (−)-Machaeriol B and (−)-Machaeriol D

Autor: Grete Hoffmann, Armido Studer

Publikováno v: Organic Letters. 20:2964-2966

Friedel–Crafts alkylation of resorcinols with (S)-cis-verbenol and subsequent cyclization allows the construction of the tetrahydrodibenzopyran core of (−)-Δ8-THC which is also found in other natural products in one step. Using a benzofuryl subs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbe2bb211c15e790de3e25e1c954764f
https://doi.org/10.1021/acs.orglett.8b01005

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Correction to 'Short and Protecting-Group-Free Approach to the (-)-Δ

Autor: Grete, Hoffmann, Armido, Studer

Publikováno v: Organic letters. 21(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d50f744b34f78ee97b7dc091c14ae1fe
https://pubmed.ncbi.nlm.nih.gov/29701472

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Short and Protecting-Group-Free Approach to the (-)-Δ

Autor: Grete, Hoffmann, Armido, Studer

Publikováno v: Organic letters. 20(10)

Friedel-Crafts alkylation of resorcinols with ( S)- cis-verbenol and subsequent cyclization allows the construction of the tetrahydrodibenzopyran core of (-)-Δ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7b04b11181973fb0706ab40f192d1aca
https://pubmed.ncbi.nlm.nih.gov/30571129

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Correction to 'Short and Protecting-Group-Free Approach to the (−)-Δ8-THC-Motif: Synthesis of THC-Analogues, (−)-Machaeriol B and (−)-Machaeriol D'

Autor: Armido Studer, Grete Hoffmann

Publikováno v: Organic Letters. 21:340-340

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50d77ebb6bc52b00c4fcc602148df0b4
https://doi.org/10.1021/acs.orglett.8b03908

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Electrochemical simulation of metabolic reactions of the secondary fungal metabolites alternariol and alternariol methyl ether

Autor: Grete Hoffmann, Hannah Simon, Hans-Ulrich Humpf, Uwe Karst, Florian Hübner

Publikováno v: Analytical and bioanalytical chemistry. 408(10)

Mycotoxins are secondary plant metabolites that have been found to cause severe diseases in humans and livestock. Exposure can take place on a daily basis since mycotoxins can be found not only in food, animal food, and dietary supplements but also i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfedee1b71d61e5f0cc3023a2e2b27e
https://pubmed.ncbi.nlm.nih.gov/26869346

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