Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gretchen Guaglianone"'
Autor:
Adam G. Kreutzer, Chelsea Marie T. Parrocha, Sepehr Haerianardakani, Gretchen Guaglianone, Jennifer T. Nguyen, Michelle N. Diab, William Yong, Mari Perez-Rosendahl, Elizabeth Head, James S. Nowick
Publikováno v:
ACS Central Science, Vol 10, Iss 1, Pp 104-121 (2023)
Externí odkaz:
https://doaj.org/article/098b29bada2f49a389917a993817e744
Autor:
Adam G. Kreutzer, Gretchen Guaglianone, Stan Yoo, Chelsea Marie T. Parrocha, Sarah M. Ruttenberg, Ryan J. Malonis, Karen Tong, Yu-Fu Lin, Jennifer T. Nguyen, William J. Howitz, Michelle N. Diab, Imane L. Hamza, Jonathan R. Lai, Vicki H. Wysocki, James S. Nowick
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The assembly of the β-amyloid peptide (Aβ) to form oligomers and fibrils is closely associated with the pathogenesis and progression of Alzheimer’s disease. Aβ is a shape-shifting peptide capable of adopting many conformations and folds within t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa8a8b8c19344edb7a9eb68d6eb71519
https://doi.org/10.1073/pnas.2219216120
https://doi.org/10.1073/pnas.2219216120
Autor:
William J. Howitz, Gretchen Guaglianone, Kate J. McKnelly, Katelyn Haduong, Shareen N. Ashby, Mohamed Laayouni, James S. Nowick
Publikováno v:
ACS Chem Neurosci
This work probes the role of charge in the oligomeric assembly, toxicity, and membrane destabilization of a series of peptides derived from Aβ and the E22Q and E22K familial mutants. In the mutant Aβ peptides, an acidic residue (E) is replaced with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed260d9ba82790ae5fcfa6f1d5d66da2
https://doi.org/10.1021/acschemneuro.1c00833
https://doi.org/10.1021/acschemneuro.1c00833
Autor:
Gretchen Guaglianone, Belén Torrado, Yu-Fu Lin, Matthew C. Watkins, Vicki H. Wysocki, Enrico Gratton, James S. Nowick
Publikováno v:
ACS chemical neuroscience, vol 13, iss 16
Aβ oligomers play a central role in the neurodegeneration observed with Alzheimer's disease. Our laboratory has developed covalently stabilized trimers derived from residues 17-36 of Aβ as model systems for studying Aβ oligomers. In the current st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578ce49765e23371f9ad4d0ee9e7c105
https://pubmed.ncbi.nlm.nih.gov/35892278
https://pubmed.ncbi.nlm.nih.gov/35892278
Publikováno v:
Chemical science. 13(44)
The antibiotic teixobactin is a promising drug candidate against drug-resistant pathogens, such as MRSA and VRE, but forms insoluble gels that may limit intravenous administration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ad17de58858bc671fb8c705a7fbf656
https://pubmed.ncbi.nlm.nih.gov/36425497
https://pubmed.ncbi.nlm.nih.gov/36425497
Autor:
Adam G. Kreutzer, Tuan D. Samdin, Sepehr Haerianardakani, James S. Nowick, Patrick J. Salveson, Gretchen Guaglianone
Publikováno v:
J Am Chem Soc
Oligomers of the β-amyloid peptide, Aβ, play a central role in the pathogenesis and progression of Alzheimer’s disease. Trimers and higher-order oligomers composed of trimers are thought to be the most neurotoxic Aβ oligomers. To gain insights i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b27863ebe8c599c164692b9824c474
https://doi.org/10.1021/jacs.0c09281
https://doi.org/10.1021/jacs.0c09281
Autor:
Stan Yoo, James S. Nowick, William J. Howitz, Jonathan Lin, Li Xing, Adam G. Kreutzer, Grace Huizar, Michael A. Morris, Hannah Jusuf, Sheng Zhang, Jian-Guo Zheng, Gretchen Guaglianone
Publikováno v:
Biochemistry
Fluorescent derivatives of the β-amyloid peptides (Aβ) are valuable tools for studying the interactions of Aβ with cells. Facile access to labeled expressed Aβ offers the promise of Aβ with greater sequence and stereochemical integrity, without
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9989b1e5854bfdcca654482fa3733888
https://europepmc.org/articles/PMC9059633/
https://europepmc.org/articles/PMC9059633/
Autor:
Michael A. Morris, Chelsea Marie T. Parrocha, Carter T. Butts, Maj Krumberger, Gretchen Guaglianone, Adam G. Kreutzer, James S. Nowick, Elizabeth M. Diessner
Publikováno v:
European Journal of Medicinal Chemistry
This paper presents the design and study of a first-in-class cyclic peptide inhibitor against the SARS-CoV-2 main protease (Mpro). The cyclic peptide inhibitor is designed to mimic the conformation of a substrate at a C-terminal autolytic cleavage si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8822a5694e3b277154fc0e02b518174a
https://pubmed.ncbi.nlm.nih.gov/34023738
https://pubmed.ncbi.nlm.nih.gov/34023738
Autor:
Stan Yoo, Michael A. Morris, James S. Nowick, William J. Howitz, Jonathan Lin, Adam G. Kreutzer, Gretchen Guaglianone, Hannah Jusuf, Li Xing, Jian-Guo Zheng, Sheng Zhang, Grace Huizar
Publikováno v:
Biochemistry. 60:2272-2273
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe0418a2701bfb9370bd945729b60774
https://doi.org/10.1021/acs.biochem.1c00424
https://doi.org/10.1021/acs.biochem.1c00424
Autor:
Gretchen Guaglianone, Maj Krumberger, James S. Nowick, Chelsea Marie T. Parrocha, Adam G. Kreutzer, Michael A. Morris
This paper presents the design and study of a first-in-class cyclic peptide inhibitor against the SARS-CoV-2 main protease (Mpro). The cyclic peptide inhibitor is designed to mimic the conformation of a substrate at a C-terminal autolytic cleavage si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e4b35a8cef53b4f43528c14ed2b9222
https://doi.org/10.1101/2020.08.03.234872
https://doi.org/10.1101/2020.08.03.234872