ERK Hyperactivation Serves as a Unified Mechanism of Escape in Intrinsic and Acquired CDK4/6 Inhibitor Resistance in Acral Lentiginous Melanoma

Autor: Vito Rebecca, Kasturee Jagirdar, Marie Portuallo, Meihan Wei, Matthew Wilhide, Jeremy Bravo, Bailey Robertson, Gretchen Alicea, Crsytal Aguh, Min Xiao, Tetiana Godok, Dylan Fingerman, Gregory Brown, Meenhard Herlyn, Brian Guo, Eneda Toska, Daniel Zabransky, Bradley Wubbenhorst, Katherine Nathanson, Shawn Kwatra, Yogesh Goyal, Hongkai Ji, Qin Liu

Patients with metastatic acral lentiginous melanoma (ALM) suffer worse outcomes relative to patients with other forms of cutaneous melanoma (CM), and do not benefit as well to approved melanoma therapies. Identification of cyclin-dependent kinase 4 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73ba0c52a6b96f1ea68483275488409b
https://doi.org/10.21203/rs.3.rs-2817876/v1

Abstract IA014: The role of aging in reactivation from metastatic melanoma dormancy

Autor: Mitchell Fane, Yash Chhabra, Gretchen Alicea, Daniel Zabransky, Laura Hüser, Devin Maranto, Julio Aguirre-Ghiso, Ashani Weeraratna

Publikováno v: Cancer Research. 83:IA014-IA014

Disseminated cancer cells (DCCs) that escape the primary site can seed in distal tissues, but may take several years, or even decades to grow out into overt metastases, a phenomenon termed tumor dormancy. Despite its importance in metastasis and resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1a2a895c3b23b7678dc945a031cacdb
https://doi.org/10.1158/1538-7445.agca22-ia014

ER stress promotes antitumor effects in BRAFi/MEKi resistant human melanoma induced by natural compound 4-nerolidylcathecol (4-NC)

Autor: Silvya Stuchi Maria-Engler, Fernanda Faião-Flores, Erica Aparecida de Oliveira, Gretchen Alicea-Rebecca, Silvia Berlanga de Moraes Barros, Débora Kristina Alves-Fernandes, Ashani T. Weeraratna, Keiran S.M. Smalley

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Melanoma accounts for only 4% of malignant neoplasms of the skin, but is considered the most serious because it is highly deadly. Mutations in the MAPK (Ras-Raf-MEK-ERK) pathway is closely linked to the lack of control of cell proliferation. Especial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625025e87c12ca290cefd3aa4b0577d9
https://pubmed.ncbi.nlm.nih.gov/30550954