Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions

Autor: John P. Overington, Prson Gautam, Balaguru Ravikumar, Markus Vähä-Koskela, Abhishekh Gupta, Alok Jaiswal, Liye He, Suleiman A. Khan, Gopal Peddinti, Brinton Seashore-Ludlow, Andrew R. Leach, Laxman Yetukuri, Zaid Alam, Mehreen Ali, Arjan J. van Adrichem, Gretchen A. Repasky, Elina Parri, Krister Wennerberg, Anne Hersey, Anna-Lena Gustavsson, Ella Karjalainen, Tero Aittokallio, Anni Rebane, Ziaurrehman Tanoli, Janica Wakkinen, Jing Tang

Publikováno v: Cell Chemical Biology
Tang, J, Tanoli, Z-R, Ravikumar, B, Alam, Z, Vähä-Koskela, M, Peddinti, G, van Adrichem, A J, Wakkinen, J, Jaiswal, A, Karjalainen, E, Gautam, P, He, L, Parri, E, Khan, S, Gupta, A, Ali, M, Yetukuri, L, Gustavsson, A-L, Seashore-Ludlow, B, Hersey, A, Leach, A R, Overington, J P, Repasky, G, Wennerberg, K & Aittokallio, T 2018, ' Drug Target Commons : A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions ', Cell Chemical Biology, vol. 25, no. 2, pp. 224-229.e2 . https://doi.org/10.1016/j.chembiol.2017.11.009

Summary Knowledge of the full target space of bioactive substances, approved and investigational drugs as well as chemical probes, provides important insights into therapeutic potential and possible adverse effects. The existing compound-target bioac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f1d56d48f461d6982610f3ce4bc2159
https://doi.org/10.1016/j.chembiol.2017.11.009

Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP

Autor: Ari M. P. Koskinen, Gretchen A. Repasky, Laura Turunen, Arjan J. van Adrichem, Anna Lehto, Krister Wennerberg, Annika E Fagerholm, Jani Saarela

Publikováno v: Combinatorial Chemistry & High Throughput Screening
University of Helsinki
University of Copenhagen
ResearcherID

The Rho family of Ras superfamily small GTPases regulates a broad range of biological processes such as migration, differentiation, cell growth and cell survival. Therefore, the availability of small molecule modulators as tool compounds could greatl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c670ac6bab82aaaeb5072587b0518dd
http://europepmc.org/articles/PMC4435052

Molecular Changes During Acute Myeloid Leukemia (AML) Evolution and Identification of Novel Treatment Strategies Through Molecular Stratification

Autor: Gretchen A. Repasky, Ella Karjalainen

Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by impaired differentiation and uncontrollable proliferation of myeloid progenitor cells. Due to high relapse rates, overall survival for this rapidly progressing disease is poo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72d7ecff7d2ee47673e0225eb2f11cee
https://doi.org/10.1016/bs.pmbts.2016.09.005

Involvement of Ras Activation in Human Breast Cancer Cell Signaling, Invasion, and Anoikis

Autor: Lynn B. Eckert, Channing J. Der, Gretchen A. Repasky, Hong Zhou, Carolyn I. Sartor, Aylin S. Ülkü, Aidan McFall

Publikováno v: Cancer Research. 64:4585-4592

Although mutated forms of ras are not associated with the majority of breast cancers (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd07db01999d26b2bc0224c45ac198e0
https://doi.org/10.1158/0008-5472.can-04-0396

Role of R-Ras in Cell Growth

Autor: Ariella B. Hanker, Gretchen A. Repasky, Natalia Mitin, Adrienne D. Cox, Channing J. Der

Publisher Summary This chapter summarizes the general features of R-Ras proteins that are shared with Ras proteins, and then highlights unique features of each R-Ras protein. Ras proteins (H-Ras, K-Ras4A and 4B, and N-Ras) are regulators of signal tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c080bb81bd72995a4f9c96d814cae217
https://doi.org/10.1016/b978-0-12-374145-5.00214-x