Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Greta Wegner"'
1
Considerations for Soluble Protein Biomarker Blood Sample Matrix Selection
Autor: Jon E. Peterson, Daoyu Duan, Yan G. Ni, Connie Wang, Chad Ray, John Allinson, Martha Hokom, Sara Hamon, Joel A Mathews, Xuemei Zhao, Greta Wegner
Publikováno v: The AAPS Journal. 22
Blood-based soluble protein biomarkers provide invaluable clinical information about patients and are used as diagnostic, prognostic, and pharmacodynamic markers. The most commonly used blood sample matrices are serum and different types of plasma. I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdce6a10ec70389b5df9991c05696256
https://doi.org/10.1208/s12248-020-0412-0
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2
P3-18-07: Multiplex RTK Inhibitor Screening Utilizing a Plate-Based Immunoassay with Near-Infrared Detection
Autor: RA Felix, David J. Finkel, Amy James, Greta Wegner
Publikováno v: Cancer Research. 71:P3-18
Receptor-tyrosine kinases (RTKs) are transmembrane proteins that have been implicated in various cancers and are considered therapeutic targets. The phosphorylation of RTKs on tyrosine residues leads to their activation. We have previously used the P
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1303e82958abb078346170d88e34ef44
https://doi.org/10.1158/0008-5472.sabcs11-p3-18-07
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3
Abstract 3978: B7-H1/PD-L1 soluble expression in multiple cancer subtypes: High sensitivity measurement by immunoassay
Autor: Paul Younge, Nathan Steere, Melissa Floren, Greta Wegner, Justin Haworth, Samuel Thayer, Michael G. Anderson, Isabel O'Brien, Rainer Grant, Kathryn M. Brumbaugh
Publikováno v: Cancer Research. 77:3978-3978
Aberrant expression of the B7-H1/PD-L1 immunomodulatory molecule is evident in many forms of cancer. The evidence for increased protein levels of B7-H1/PD-L1 comes largely from immunohistochemistry analysis of surgical and biopsy specimens. While sev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45037d1b1565ea21ae8164904086c7e4
https://doi.org/10.1158/1538-7445.am2017-3978
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5
Abstract 2998: MLN4924 inhibition of Cullin-Ring ligases activates a hypoxic response and secretion of tumor promoting factors in human MCF7 breast cancer cells
Autor: James J. Rivard, Kevin J. Reagan, Erin Eleria, Greta Wegner, Neal Lee, Kathy Brumbaugh, Amy James
Publikováno v: Cancer Research. 75:2998-2998
Hypoxia-inducible factors (HIFs) are the key transcription factors that mediate the cellular response to low oxygen tension. During normoxia, HIF activity is tightly controlled by its oxygen-dependent prolyl hydroxylation which allows polyubiquitinat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81f18f34b3538a315c6b40cb8bd2e80c
https://doi.org/10.1158/1538-7445.am2015-2998
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6
Abstract 3461: Profiling the effects of MEK inhibition on kinase phosphorylation and protease secretion using antibody arrays
Autor: Dave Finkel, Erin Eleria, Wen-Chieh Liao, Greta Wegner, Amy James
Publikováno v: Cancer Research. 74:3461-3461
The frequent deregulation of ERK signaling in tumors has led to the development of MEK inhibitors, which have proven to be clinically relevant to malignancies harboring BRAF mutations. Since proliferation and invasion are intertwined aspects of metas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5033fd65ed33a66b97f29c48fb344e9e
https://doi.org/10.1158/1538-7445.am2014-3461
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7
Profiling secreted cytokines from human Th2 and Th17 cells using antibody arrays (TECH1P.845)
Autor: David Finkel, Amy James, Kathy Brumbaugh, Sanjeev Dhawan, Christine Goetz, Jody Bonnevier, Greta Wegner
Publikováno v: The Journal of Immunology. 192:69.13-69.13
Naive T Helper cells can differentiate into Th1, Th2, and Th17 lineages which each secrete a characteristic signature of molecules. In this study, we demonstrate the utility of antibody arrays to monitor T cell differentiation processes. Naive T cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ceb836ba4be8d7c50d0e628090d434d0
https://doi.org/10.4049/jimmunol.192.supp.69.13
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8
Modulating the tumor necrosis factor-α induced inflammatory response in human colonic epithelial cells by inhibiting NF-κB signaling (CCR5P.258)
Autor: James Rivard, Amy James, Greta Wegner, Kevin Reagan
Publikováno v: The Journal of Immunology. 192:181.12-181.12
In colonic epithelia, tumor necrosis factor alpha (TNF-α) secreted by inflammatory cells is a key mediator of inflammatory bowel disease. TNF-α is a well-characterized activator of the NF-κB signaling pathway in intestinal epithelial cells and is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d69c1f707770c7582daf53663566e5f
https://doi.org/10.4049/jimmunol.192.supp.181.12
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9
Abstract 382: Profiling angiogenic factors, RTK phosphorylation and inhibition events in breast cancer and endothelial cells using antibody arrays
Autor: Greta Wegner, Amy James, David J. Finkel
Publikováno v: Cancer Research. 73:382-382
Tumor growth and progression in breast cancer is dependent on angiogenesis, the growth of new vasculature from pre-existing vessels. Since invasive and in situ breast cancers express many angiogenic factors, we examined the profiles of angiogenesis-r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f75ab58c1bc397ea4076973e642d638e
https://doi.org/10.1158/1538-7445.am2013-382
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