Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Greta Simionato"'
The Gárdos Channel and Piezo1 Revisited: Comparison between Reticulocytes and Mature Red Blood Cells
Autor:
Polina Petkova-Kirova, Nicoletta Murciano, Giulia Iacono, Julia Jansen, Greta Simionato, Min Qiao, Carmen Van der Zwaan, Maria Giustina Rotordam, Thomas John, Laura Hertz, Arjan J. Hoogendijk, Nadine Becker, Christian Wagner, Marieke Von Lindern, Stephane Egee, Emile Van den Akker, Lars Kaestner
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1416 (2024)
The Gárdos channel (KCNN4) and Piezo1 are the best-known ion channels in the red blood cell (RBC) membrane. Nevertheless, the quantitative electrophysiological behavior of RBCs and its heterogeneity are still not completely understood. Here, we use
Externí odkaz:
https://doaj.org/article/e25eaf0b23bd429f9d46c6d460cc6f55
Autor:
Steffen M Recktenwald, Greta Simionato, Marcelle GM Lopes, Fabia Gamboni, Monika Dzieciatkowska, Patrick Meybohm, Kai Zacharowski, Andreas von Knethen, Christian Wagner, Lars Kaestner, Angelo D'Alessandro, Stephan Quint
Publikováno v:
eLife, Vol 11 (2022)
Coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and can affect multiple organs, among which is the circulatory system. Inflammation and mortality risk markers were previously detected
Externí odkaz:
https://doaj.org/article/b0ea9f4b1c7e4977b9f36da87f69b0cc
Autor:
Kevin Peikert, Alexander Storch, Andreas Hermann, G. Bernhard Landwehrmeyer, Ruth H. Walker, Greta Simionato, Lars Kaestner, Adrian Danek
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/bca5580bbe60406ca4368edb12dee373
Autor:
Mohammed Nouaman, Alexis Darras, Thomas John, Greta Simionato, Minke A. E. Rab, Richard van Wijk, Matthias W. Laschke, Lars Kaestner, Christian Wagner, Steffen M. Recktenwald
Publikováno v:
Cells, Vol 12, Iss 11, p 1529 (2023)
Blood flow in the microcirculatory system is crucially affected by intrinsic red blood cell (RBC) properties, such as their deformability. In the smallest vessels of this network, RBCs adapt their shapes to the flow conditions. Although it is known t
Externí odkaz:
https://doaj.org/article/c73fcd6fa1d743668fb0e240aba52bcc
Autor:
Steffen M. Recktenwald, Marcelle G. M. Lopes, Stephana Peter, Sebastian Hof, Greta Simionato, Kevin Peikert, Andreas Hermann, Adrian Danek, Kai van Bentum, Hermann Eichler, Christian Wagner, Stephan Quint, Lars Kaestner
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
In many medical disciplines, red blood cells are discovered to be biomarkers since they “experience” various conditions in basically all organs of the body. Classical examples are diabetes and hypercholesterolemia. However, recently the red blood
Externí odkaz:
https://doaj.org/article/7fcdd3b5bbff42dbbae00d8a428de183
Autor:
Asya Mahkro, Inga Hegemann, Elena Seiler, Greta Simionato, Viviana Claveria, Nikolay Bogdanov, Clelia Sasselli, Paul Torgerson, Lars Kaestner, Markus G. Manz, Jeroen S. Goede, Max Gassmann, Anna Bogdanova
Publikováno v:
eJHaem, Vol 1, Iss 1, Pp 23-34 (2020)
Abstract An increase in abundance and activity of N‐methyl D‐aspartate receptors (NMDAR) was previously reported for red blood cells (RBCs) of sickle cell disease (SCD) patients. Increased Ca2+ uptake through the receptor supported dehydration an
Externí odkaz:
https://doaj.org/article/c89140f146254120aeb84e335e00cccc
Autor:
Greta Simionato, Richard van Wijk, Stephan Quint, Christian Wagner, Paola Bianchi, Lars Kaestner
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/890a9dc0b962451ba481b490ce55030a
Autor:
Greta Simionato, Konrad Hinkelmann, Revaz Chachanidze, Paola Bianchi, Elisa Fermo, Richard van Wijk, Marc Leonetti, Christian Wagner, Lars Kaestner, Stephan Quint
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008934 (2021)
The investigation of cell shapes mostly relies on the manual classification of 2D images, causing a subjective and time consuming evaluation based on a portion of the cell surface. We present a dual-stage neural network architecture for analyzing fin
Externí odkaz:
https://doaj.org/article/abbea161750f4e0c8f2d62cf2a7c9fcd
Autor:
Greta Simionato, Antonia Rabe, Joan Sebastián Gallego-Murillo, Carmen van der Zwaan, Arie Johan Hoogendijk, Maartje van den Biggelaar, Giampaolo Minetti, Anna Bogdanova, Heimo Mairbäurl, Christian Wagner, Lars Kaestner, Emile van den Akker
Publikováno v:
Cells, Vol 11, Iss 7, p 1082 (2022)
Hypoxia is associated with increased erythropoietin (EPO) release to drive erythropoiesis. At high altitude, EPO levels first increase and then decrease, although erythropoiesis remains elevated at a stable level. The roles of hypoxia and related EPO
Externí odkaz:
https://doaj.org/article/6742e1db5d014132809e161fb13bf0c5
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Mean values of hematological parameters are currently used in the clinical laboratory settings to characterize red blood cell properties. Those include red blood cell indices, osmotic fragility test, eosin 5-maleimide (EMA) test, and deformability as
Externí odkaz:
https://doaj.org/article/0ddb06ae78a440b18dd3edee31edd5ad