Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Greta Guarda"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The nucleotide-binding and oligomerization domain-like receptors (NLRs) NLR family CARD domain-containing protein 5 (NLRC5) and Class II Major Histocompatibility Complex Transactivator (CIITA) are transcriptional regulators of major histocompatibilit
Externí odkaz:
https://doaj.org/article/927c3d47eb6a418fa84e079df55b3301
Autor:
Filippo Spriano, Giulio Sartori, Jacopo Sgrignani, Laura Barnabei, Alberto J. Arribas, Matilde Guala, Ana Maria Carrasco Del Amor, Meagan R. Tomasso, Chiara Tarantelli, Luciano Cascione, Gaetanina Golino, Maria E Riveiro, Roberta Bortolozzi, Antonio Lupia, Francesco Paduano, Samuel Huguet, Keyvan Rezai, Andrea Rinaldi, Francesco Margheriti, Pedro Ventura, Greta Guarda, Giosuè Costa, Roberta Rocca, Alberto Furlan, Luuk M. Verdonk, Paolo Innocenti, Nathaniel I. Martin, Giampietro Viola, Christoph Driessen, Emanuele Zucca, Anastasios Stathis, Digvijay Gahtory, Maurits van den Nieuwboer, Beat Bornhauser, Stefano Alcaro, Francesco Trapasso, Susana Cristobal, Shae B. Padrick, Natalina Pazzi, Franco Cavalli, Andrea Cavalli, Eugenio Gaudio, Francesco Bertoni
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Hematological cancers are among the most common cancers in adults and children. Despite significant improvements in therapies, many patients still succumb to the disease. Therefore, novel therapies are needed. The Wiskott-Aldrich syndrome protein (WA
Externí odkaz:
https://doaj.org/article/1fcdabe916834d5e99ed8d590cb92b6a
Autor:
Charlène Niogret, S. M. Shahjahan Miah, Giorgia Rota, Nicolas P. Fonta, Haiping Wang, Werner Held, Walter Birchmeier, Veronica Sexl, Wentian Yang, Eric Vivier, Ping-Chih Ho, Laurent Brossay, Greta Guarda
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The phosphatase Shp-2 was implicated in NK cell education due to its reported association with inhibitory receptors, but its function in this context is unclear. Here the authors show that Shp-2 is not required for NK cell function, but is necessary
Externí odkaz:
https://doaj.org/article/41cf5051ab934c2b9282cb0fc85ec566
Autor:
Anh Thu Dang, Juliane Strietz, Alessandro Zenobi, Hanif J. Khameneh, Simon M. Brandl, Laura Lozza, Gregor Conradt, Stefan H.E. Kaufmann, Walter Reith, Ivo Kwee, Susana Minguet, Sonia T. Chelbi, Greta Guarda
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101900- (2021)
Summary: BTN3A molecules—BTN3A1 in particular—emerged as important mediators of Vγ9Vδ2 T cell activation by phosphoantigens. These metabolites can originate from infections, e.g. with Mycobacterium tuberculosis, or by alterations in cellular me
Externí odkaz:
https://doaj.org/article/de729f8b994f4debb0363e2537507785
Autor:
Giorgia Rota, Charlène Niogret, Anh Thu Dang, Cristina Ramon Barros, Nicolas Pierre Fonta, Francesca Alfei, Leonor Morgado, Dietmar Zehn, Walter Birchmeier, Eric Vivier, Greta Guarda
Publikováno v:
Cell Reports, Vol 23, Iss 1, Pp 39-49 (2018)
Summary: In chronic infection and cancer, T cells acquire a dysfunctional state characterized by the expression of inhibitory receptors. In vitro studies implicated the phosphatase Shp-2 downstream of these receptors, including PD-1. However, whether
Externí odkaz:
https://doaj.org/article/b395a1ba02e4467bb0fd84774174e3f0
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Somewhat counterintuitively, the tyrosine phosphatase SHP-2 (SH2 domain-containing protein tyrosine phosphatase-2) is crucial for the activation of extracellular signal-regulated kinase (ERK) downstream of various growth factor receptors, thereby exe
Externí odkaz:
https://doaj.org/article/8ab155b52a5f44339503501ee257ba80
Autor:
Kristina Ludigs, Camilla Jandus, Daniel T. Utzschneider, Francesco Staehli, Stéphanie Bessoles, Anh Thu Dang, Giorgia Rota, Wilson Castro, Dietmar Zehn, Eric Vivier, Werner Held, Pedro Romero, Greta Guarda
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
NK cell tolerance to self-MHCI levels is calibrated during their development. Here the authors show that this tolerance is overcome by an inflammatory environment and that NLRC5 protects T cells from NK cell-mediated elimination by maintaining high M
Externí odkaz:
https://doaj.org/article/5daa48a82f9b456488d8d66573ddc116
Autor:
Sonia T. Chelbi, Greta Guarda
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 4, Iss 1 (2016)
The recent use of T cell-based cancer immunotherapies, such as adoptive T-cell transfer and checkpoint blockade, yields increasing clinical benefit to patients with different cancer types. However, decrease of MHC class I expression is a common mecha
Externí odkaz:
https://doaj.org/article/3a6c286fc122407a9ecd4be17cf8d967
Autor:
Kristina Ludigs, Queralt Seguín-Estévez, Sylvain Lemeille, Isabel Ferrero, Giorgia Rota, Sonia Chelbi, Chantal Mattmann, H Robson MacDonald, Walter Reith, Greta Guarda
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005088 (2015)
MHC class II (MHCII) genes are transactivated by the NOD-like receptor (NLR) family member CIITA, which is recruited to SXY enhancers of MHCII promoters via a DNA-binding "enhanceosome" complex. NLRC5, another NLR protein, was recently found to contr
Externí odkaz:
https://doaj.org/article/43e60c513221439798aebe7744bcb1a6
Autor:
Catherine Dostert, Greta Guarda, Jackeline F Romero, Philippe Menu, Olaf Gross, Aubry Tardivel, Mario-Luca Suva, Jean-Christophe Stehle, Manfred Kopf, Ivan Stamenkovic, Giampietro Corradin, Jurg Tschopp
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6510 (2009)
BACKGROUND: Characteristic symptoms of malaria include recurrent fever attacks and neurodegeneration, signs that are also found in patients with a hyperactive Nalp3 inflammasome. Plasmodium species produce a crystal called hemozoin that is generated
Externí odkaz:
https://doaj.org/article/5a1b2ef8c64c49439e4111cbba995712