Výsledky vyhledávání - "Greta Freundt"

The orphan receptor GPRC5B modulates inflammatory and fibrotic pathways in cardiac fibroblasts and mice hearts

Autor: Norbert Frey, Thomas Wieland, Greta Freundt, Hans-Joerg Hippe, Frederik Stelter, Friedrich Alexander von Samson-Himmelstjerna, Mark Luedde, Jan-Thorge Nitz

Publikováno v: Biochemical and biophysical research communications. 514(4)

Inflammation is a major driver of cardiac remodeling. Cardiac fibroblasts play an integral role in cardiac inflammation, fibrosis and remodeling. The orphan G-protein-coupled-receptor 5B of family C (GPRC5B) has recently been shown to have pro-inflam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796fca2b97b0376ae2420480bb5db99a
https://pubmed.ncbi.nlm.nih.gov/31104767

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Abstract 272: The Orphan Receptor GPRC5B Increases Pro-Inflammatory Signaling in Neonatal Rat Cardiac Fibroblasts and Cardiac MMP-9-expression in vivo

Autor: Friedrich A von Samson-Himmelstjerna, Greta Freundt, Norbert Frey, Hans-Joerg Hippe

Publikováno v: Circulation Research. 121

Background: Inflammatory processes driven by cardiac fibroblasts (CF) play a major role in cardiac fibrosis and eventually diastolic dysfunction leading to heart failure. GPRC5B, a novel G protein-coupled orphan receptor, is involved in inflammatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::035eb0152e162883d6676069ea20fd6a
https://doi.org/10.1161/res.121.suppl_1.272

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Abstract 463: The Orphan G Protein-Coupled Receptor C5B is Regulated by Hyperglycemia and Activates Pro-Inflammatory Signaling in Endothelial Cells Via the Tyrosine Kinase Fyn

Autor: Greta Freundt, Jan Thorge Nitz, Norbert Frey, Hans-Jörg Hippe

Publikováno v: Circulation Research. 121

Background: Atherosclerosis is driven by an inflammatory process of the vascular wall in which endothelial cells (EC) are decisively involved. The orphan G protein-coupled receptor GPRC5B activates inflammatory pathways in adipocytes and regulates th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::024e2086515075c484628046cc9f529e
https://doi.org/10.1161/res.121.suppl_1.463

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Preclinical study on combined chemo- and nonviral gene therapy for sensitization of melanoma using a human TNF-alpha expressing MIDGE DNA vector

Autor: Margit Lemm, Manuel Schmidt, Peter M. Schlag, Jutta Aumann, Wolfgang Walther, Greta Freundt, Iduna Fichtner, Dennis Kobelt, Burghardt Wittig, Diana Behrens

Publikováno v: Molecular Oncology

Nonviral gene therapy represents a realistic option for clinical application in cancer treatment. This preclinical study demonstrates the advantage of using the small-size MIDGE(®) DNA vector for improved transgene expression and therapeutic applica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463185a5fe47fe72e71a4b73268f42d2

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