Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Greszler SN"'
1
Akademický článek
Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds.
Autor: Ramos AL; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Goedken ER; AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States., Frank KE; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Argiriadi MA; AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States., Bazzaz S; X-Chem, Waltham, Massachusetts 02453, United States., Bian Z; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Brown JTC; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Centrella PA; X-Chem, Waltham, Massachusetts 02453, United States., Chen HJ; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Disch JS; X-Chem, Waltham, Massachusetts 02453, United States., Donner PL; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Duignan DB; AbbVie Bioresearch Center, Worcester, Massachusetts 01605, United States., Gikunju D; X-Chem, Waltham, Massachusetts 02453, United States., Greszler SN; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Guié MA; X-Chem, Waltham, Massachusetts 02453, United States., Habeshian S; X-Chem, Waltham, Massachusetts 02453, United States., Hartl HE; X-Chem, Waltham, Massachusetts 02453, United States., Hein CD; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Hutchins CW; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Jetson R; X-Chem, Waltham, Massachusetts 02453, United States., Keefe AD; X-Chem, Waltham, Massachusetts 02453, United States., Khan H; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Li HQ; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Olszewski A; X-Chem, Waltham, Massachusetts 02453, United States., Ortiz Cardona BJ; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Osuma A; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Panchal SC; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Phelan R; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Qiu W; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Shotwell JB; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Shrestha A; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Srikumaran M; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Su Z; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Sun C; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Upadhyay AK; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Wood MD; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Wu H; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Zhang R; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Zhang Y; X-Chem, Waltham, Massachusetts 02453, United States., Zhao G; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Zhu H; AbbVie Incorporated, North Chicago, Illinois 60064, United States., Webster MP; AbbVie Incorporated, North Chicago, Illinois 60064, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Apr 25; Vol. 67 (8), pp. 6456-6494. Date of Electronic Publication: 2024 Apr 04.
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2
Akademický článek
Synthesis of A-9758, an Inverse Agonist of Retinoic Acid-Related Orphan Receptor γt.
Autor: Marvin CC; Drug Discovery Science and Technology, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Greszler SN; Drug Discovery Science and Technology, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Shelat BH; Drug Discovery Science and Technology, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Voight EA; Drug Discovery Science and Technology, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
Publikováno v: ACS omega [ACS Omega] 2022 Nov 17; Vol. 7 (48), pp. 44383-44389. Date of Electronic Publication: 2022 Nov 17 (Print Publication: 2022).
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3
Akademický článek
Enabling Asymmetric Synthesis of ABBV-3748, a Corrector Compound for the Treatment of Cystic Fibrosis.
Autor: Greszler SN; Research & Development, AbbVie, Inc., 1 N Waukegan Rd, North Chicago, Illinois 60064, United States., Zhao G; Research & Development, AbbVie, Inc., 1 N Waukegan Rd, North Chicago, Illinois 60064, United States., Shelat B; Research & Development, AbbVie, Inc., 1 N Waukegan Rd, North Chicago, Illinois 60064, United States., Voight EA; Research & Development, AbbVie, Inc., 1 N Waukegan Rd, North Chicago, Illinois 60064, United States.
Publikováno v: Organic letters [Org Lett] 2022 Oct 14; Vol. 24 (40), pp. 7305-7308. Date of Electronic Publication: 2022 Sep 30.
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4
Akademický článek
Lithioarene Cycliacylation and Pd-Catalyzed Aminoethylation/Cyclization to Access Electronically Diverse Saturated Isoquinoline Derivatives.
Autor: Buchman M; Centralized Medicinal Chemistry, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Farney EP; Centralized Medicinal Chemistry, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Greszler SN; Centralized Medicinal Chemistry, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Altenbach RJ; Centralized Medicinal Chemistry, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Gfesser GA; Centralized Medicinal Chemistry, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Voight EA; Centralized Medicinal Chemistry, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
Publikováno v: The Journal of organic chemistry [J Org Chem] 2022 Jan 07; Vol. 87 (1), pp. 776-789. Date of Electronic Publication: 2021 Dec 23.
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5
Akademický článek
Fueling the Pipeline via Innovations in Organic Synthesis.
Autor: Voight EA; Drug Discovery Science & Technology, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064-1802, United States., Greszler SN; Drug Discovery Science & Technology, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064-1802, United States., Kym PR; Drug Discovery Science & Technology, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064-1802, United States.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Aug 27; Vol. 12 (9), pp. 1365-1373. Date of Electronic Publication: 2021 Aug 27 (Print Publication: 2021).
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6
Akademický článek
Desymmetrization of pibrentasvir for efficient prodrug synthesis.
Autor: Voight EA; Drug Discovery Science & Technology, AbbVie, Inc. 1 North Waukegan Road North Chicago Illinois 60064-1802 USA eric.a.voight@abbvie.com., Greszler SN; Drug Discovery Science & Technology, AbbVie, Inc. 1 North Waukegan Road North Chicago Illinois 60064-1802 USA eric.a.voight@abbvie.com., Hartung J; Process Research and Development, AbbVie, Inc. 1 North Waukegan Road North Chicago Illinois 60064-1802 USA., Ji J; Process Research and Development, AbbVie, Inc. 1 North Waukegan Road North Chicago Illinois 60064-1802 USA., Klix RC; Process Research and Development, AbbVie, Inc. 1 North Waukegan Road North Chicago Illinois 60064-1802 USA., Randolph JT; Drug Discovery Science & Technology, AbbVie, Inc. 1 North Waukegan Road North Chicago Illinois 60064-1802 USA eric.a.voight@abbvie.com., Shelat BH; Process Research and Development, AbbVie, Inc. 1 North Waukegan Road North Chicago Illinois 60064-1802 USA., Waters JE; Drug Discovery Science & Technology, AbbVie, Inc. 1 North Waukegan Road North Chicago Illinois 60064-1802 USA eric.a.voight@abbvie.com., DeGoey DA; Drug Discovery Science & Technology, AbbVie, Inc. 1 North Waukegan Road North Chicago Illinois 60064-1802 USA eric.a.voight@abbvie.com.
Publikováno v: Chemical science [Chem Sci] 2021 Jun 29; Vol. 12 (29), pp. 10076-10082. Date of Electronic Publication: 2021 Jun 29 (Print Publication: 2021).
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7
Akademický článek
Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530).
Autor: Randolph JT; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Voight EA; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Greszler SN; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Uno BE; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Newton JN; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Gleason KM; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Stolarik D; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Van Handel C; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Bow DAJ; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., DeGoey DA; Abbvie Incorporated, Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Oct 08; Vol. 63 (19), pp. 11034-11044. Date of Electronic Publication: 2020 Sep 17.
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8
Akademický článek
General Asymmetric Synthesis of Densely Functionalized Pyrrolidines via Endo -Selective [3+2] Cycloaddition of β-Quaternary-Substituted Nitroalkenes and Azomethine Ylides.
Autor: Greszler SN; Research & Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Zhao G; Research & Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Buchman M; Research & Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Searle XB; Research & Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Liu B; Research & Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Voight EA; Research & Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
Publikováno v: The Journal of organic chemistry [J Org Chem] 2020 Jun 05; Vol. 85 (11), pp. 7620-7632. Date of Electronic Publication: 2020 May 21.
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9
Akademický článek
Enabling Synthesis of ABBV-2222, A CFTR Corrector for the Treatment of Cystic Fibrosis.
Autor: Greszler SN; Research & Development, AbbVie, Inc. , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Shelat B; Research & Development, AbbVie, Inc. , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States., Voight EA; Research & Development, AbbVie, Inc. , 1 North Waukegan Road , North Chicago , Illinois 60064 , United States.
Publikováno v: Organic letters [Org Lett] 2019 Jul 19; Vol. 21 (14), pp. 5725-5727. Date of Electronic Publication: 2019 Jul 01.
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10
Akademický článek
Synthesis of ABBV-168, a 2'-Bromouridine for the Treatment of Hepatitis C.
Autor: Voight EA; Discovery Chemistry and Technology , AbbVie, Inc. , 1 North Waukegan Road , North Chicago , Illinois 60064-1802 , United States., Brown BS; Discovery Chemistry and Technology , AbbVie, Inc. , 1 North Waukegan Road , North Chicago , Illinois 60064-1802 , United States., Greszler SN; Discovery Chemistry and Technology , AbbVie, Inc. , 1 North Waukegan Road , North Chicago , Illinois 60064-1802 , United States., Halvorsen GT; Discovery Chemistry and Technology , AbbVie, Inc. , 1 North Waukegan Road , North Chicago , Illinois 60064-1802 , United States., Zhao G; Discovery Chemistry and Technology , AbbVie, Inc. , 1 North Waukegan Road , North Chicago , Illinois 60064-1802 , United States., Kruger AW; Process Research and Development , AbbVie, Inc. , 1401 Sheridan Road , North Chicago , Illinois 60064-1802 , United States., Hartung J; Process Research and Development , AbbVie, Inc. , 1401 Sheridan Road , North Chicago , Illinois 60064-1802 , United States., Lukin KA; Process Research and Development , AbbVie, Inc. , 1401 Sheridan Road , North Chicago , Illinois 60064-1802 , United States., Martinez SR; Process Research and Development , AbbVie, Inc. , 1401 Sheridan Road , North Chicago , Illinois 60064-1802 , United States., Moschetta EG; Process Research and Development , AbbVie, Inc. , 1401 Sheridan Road , North Chicago , Illinois 60064-1802 , United States., Tudesco MT; Process Research and Development , AbbVie, Inc. , 1401 Sheridan Road , North Chicago , Illinois 60064-1802 , United States., Ide ND; Process Research and Development , AbbVie, Inc. , 1401 Sheridan Road , North Chicago , Illinois 60064-1802 , United States.
Publikováno v: The Journal of organic chemistry [J Org Chem] 2019 Apr 19; Vol. 84 (8), pp. 4723-4734. Date of Electronic Publication: 2018 Nov 19.
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