Comparative small molecule screening of primary human acute leukemias, engineered human leukemia and leukemia cell lines.

Autor: Safa-Tahar-Henni S; Laboratory for High Throughput Biology, Montréal, QC, Canada.; Institute for Research in Immunology and Cancer, Montréal, QC, Canada., Páez Martinez K; Laboratory for High Throughput Biology, Montréal, QC, Canada.; Institute for Research in Immunology and Cancer, Montréal, QC, Canada., Gress V; Unité de recherche en immuno-hémato-oncologie Charles-Bruneau, Centre de recherche Azrieli du CHU Sainte-Justine, Montréal, QC, Canada., Esparza N; Centre de recherche en infectiologie du CHUL, Centre de recherche du CHU de Québec - Université Laval, Québec City, QC, Canada., Roques É; Laboratory for High Throughput Biology, Montréal, QC, Canada.; Institute for Research in Immunology and Cancer, Montréal, QC, Canada., Bonnet-Magnaval F; Laboratory for High Throughput Biology, Montréal, QC, Canada.; Institute for Research in Immunology and Cancer, Montréal, QC, Canada., Bilodeau M; Unité de recherche en immuno-hémato-oncologie Charles-Bruneau, Centre de recherche Azrieli du CHU Sainte-Justine, Montréal, QC, Canada., Gagné V; Laboratory for High Throughput Biology, Montréal, QC, Canada.; Institute for Research in Immunology and Cancer, Montréal, QC, Canada., Bresson E; Centre de recherche en infectiologie du CHUL, Centre de recherche du CHU de Québec - Université Laval, Québec City, QC, Canada., Cardin S; Unité de recherche en immuno-hémato-oncologie Charles-Bruneau, Centre de recherche Azrieli du CHU Sainte-Justine, Montréal, QC, Canada., El-Hachem N; Unité de recherche en immuno-hémato-oncologie Charles-Bruneau, Centre de recherche Azrieli du CHU Sainte-Justine, Montréal, QC, Canada., Iasenza I; Centre for Translational Biology, McGill University Heath Centre Research Institute, Montréal, QC, Canada., Alzial G; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; Metabolic and Epigenetic Alterations in Cancer Research unit, Montréal, QC, Canada., Boivin I; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; Molecular Genetics of Stem Cells Research Unit, Montréal, QC, Canada., Nakamichi N; Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada., Soufflet AC; Unité de recherche en immuno-hémato-oncologie Charles-Bruneau, Centre de recherche Azrieli du CHU Sainte-Justine, Montréal, QC, Canada., Mirela Pascariu C; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; Proteomics and Bioanalytical Mass Spectrometry Research Unit, Montréal, QC, Canada., Duchaine J; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; High throughput screening platform, Montréal, QC, Canada., Mathien S; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; High throughput screening platform, Montréal, QC, Canada., Bonneil É; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; Proteomics and Bioanalytical Mass Spectrometry Research Unit, Montréal, QC, Canada., Eppert K; Centre for Translational Biology, McGill University Heath Centre Research Institute, Montréal, QC, Canada.; Department of Pediatrics, McGill University, Montréal, QC, Canada., Marinier A; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; Medicinal Chemistry/Drug Discovery Unit, Montréal, QC, Canada.; Department of Chemistry, Université de Montréal, Montréal, QC, Canada., Sauvageau G; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; Molecular Genetics of Stem Cells Research Unit, Montréal, QC, Canada.; Institut universitaire d'hémato-oncologie et de thérapie cellulaire, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada.; Quebec Leukemia Cell Bank, Maisonneuve-Rosemont Hospital Research Center, Montréal, QC, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Deblois G; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; Faculty of Medicine, Faculty of Pharmacy, University of Montréal, Montréal, QC, Canada., Thibault P; Institute for Research in Immunology and Cancer, Montréal, QC, Canada.; Proteomics and Bioanalytical Mass Spectrometry Research Unit, Montréal, QC, Canada.; Department of Chemistry, Faculty of Arts and Sciences, Université de Montréal, Montréal, QC, Canada., Hébert J; Institut universitaire d'hémato-oncologie et de thérapie cellulaire, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada.; Quebec Leukemia Cell Bank, Maisonneuve-Rosemont Hospital Research Center, Montréal, QC, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Eaves CJ; Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Cellot S; Unité de recherche en immuno-hémato-oncologie Charles-Bruneau, Centre de recherche Azrieli du CHU Sainte-Justine, Montréal, QC, Canada. sonia.cellot@umontreal.ca.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada. sonia.cellot@umontreal.ca., Barabé F; Centre de recherche en infectiologie du CHUL, Centre de recherche du CHU de Québec - Université Laval, Québec City, QC, Canada. Frederic.Barabe@crchudequebec.ulaval.ca.; Department of Medicine, Université Laval, Quebec City, QC, Canada. Frederic.Barabe@crchudequebec.ulaval.ca., Wilhelm BT; Laboratory for High Throughput Biology, Montréal, QC, Canada. brian.wilhelm@umontreal.ca.; Institute for Research in Immunology and Cancer, Montréal, QC, Canada. brian.wilhelm@umontreal.ca.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada. brian.wilhelm@umontreal.ca.

Publikováno v: Leukemia [Leukemia] 2024 Oct 29. Date of Electronic Publication: 2024 Oct 29.

CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216.

Autor: Gress V; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Roussy M; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Boulianne L; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Department of Pathology, McGill University, Montréal, QC, Canada., Bilodeau M; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., Cardin S; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., El-Hachem N; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., Lisi V; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., Khakipoor B; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., Rouette A; Molecular Diagnostic Laboratory, Centre Hospitalier Universitaire Sainte-Justine, Montréal, QC, Canada., Farah A; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., Théret L; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada., Aubert L; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada., Fatima F; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Department of Pathology, McGill University, Montréal, QC, Canada., Audemard É; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada., Thibault P; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada., Bonneil É; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada., Chagraoui J; Molecular Genetics of Stem Cells Laboratory, Institute for Research in Immunology and Cancer, Montréal, Québec, Canada., Laramée L; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., Gendron P; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada., Jouan L; Molecular Diagnostic Laboratory, Centre Hospitalier Universitaire Sainte-Justine, Montréal, QC, Canada., Jammali S; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., Paré B; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., Simpson SM; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada., Tran TH; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Duval M; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Teira P; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Bittencourt H; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Santiago R; Division of Hematology-Oncology, Centre Hospitalier Universitaire de Québec-Université Laval, Québec City, QC, Canada.; Centre de recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Québec City, QC, Canada., Barabé F; Centre de recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Québec City, QC, Canada.; Department of Medicine, Faculty of Medicine, Université Laval, Québec City, QC, Canada., Sauvageau G; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Molecular Genetics of Stem Cells Laboratory, Institute for Research in Immunology and Cancer, Montréal, Québec, Canada.; Division of Hematology, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada., Smith MA; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Hébert J; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Division of Hematology-Oncology and Quebec Leukemia Cell Bank, Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada., Roux PP; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada.; Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Gruber TA; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA.; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA., Lavallée VP; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada., Wilhelm BT; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada., Cellot S; Pediatric Hematology-Oncology Division, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, QC, Canada.; Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.

Publikováno v: Blood advances [Blood Adv] 2024 Jan 09; Vol. 8 (1), pp. 112-129.

Histopathological patterns and immunophenotyping of feline lymphomas and incidence in Metropolitan Bangkok, Thailand.

Autor: Jedsada Siripoonsub¹ bongbank.jeds@gmail.com, Sirintra Sirivisoot¹ sirintra.s@chula.ac.th, Somporn Techangamsuwan¹ somporn.t@chula.ac.th, Anudep Rungsipipat¹ anudep.r@chula.ac.th

Publikováno v: Veterinary World. Oct2024, Vol. 17 Issue 10, p2225-2234. 10p.

Developmental interplay between transcriptional alterations and a targetable cytokine signaling dependency in pediatric ETO2::GLIS2 leukemia.

Autor: Alonso-Pérez, Verónica^1,2,3 (AUTHOR), Galant, Klaudia^1,2,3 (AUTHOR), Boudia, Fabien⁴ (AUTHOR), Robert, Elie⁴ (AUTHOR), Aid, Zakia⁴ (AUTHOR), Renou, Laurent^1,2,3 (AUTHOR), Barroca, Vilma^1,2,5 (AUTHOR), Devanand, Saryiami^1,2,5 (AUTHOR), Babin, Loélia⁶ (AUTHOR), Rouiller-Fabre, Virginie^1,2 (AUTHOR), Moison, Delphine^1,2 (AUTHOR), Busso, Didier^1,2,7 (AUTHOR), Piton, Guillaume^1,2,7 (AUTHOR), Metereau, Christophe⁴ (AUTHOR), Abermil, Nassera⁸ (AUTHOR), Ballerini, Paola⁹ (AUTHOR), Hirsch, Pierre⁸ (AUTHOR), Haddad, Rima^1,2,3 (AUTHOR), Martinovic, Jelena¹⁰ (AUTHOR), Petit, Arnaud⁹ (AUTHOR)

Publikováno v: Molecular Cancer. 9/20/2024, Vol. 23 Issue 1, p1-24. 24p.

CBFA2T3 Is PPARA Sensitive and Attenuates Fasting-Induced Lipid Accumulation in Mouse Liver.

Autor: Kim, Donghwan^1,2 (AUTHOR) gonzalef@mail.nih.gov, Ha, Sang Keun^1,3 (AUTHOR), Gonzalez, Frank J.² (AUTHOR)

Publikováno v: Cells (2073-4409). May2024, Vol. 13 Issue 10, p831. 12p.