PYK2 senses calcium through a disordered dimerization and calmodulin-binding element

Autor: Afaque A. Momin, Tiago Mendes, Philippe Barthe, Camille Faure, SeungBeom Hong, Piao Yu, Gress Kadaré, Mariusz Jaremko, Jean-Antoine Girault, Łukasz Jaremko, Stefan T. Arold

Publikováno v: Communications Biology
Communications Biology, 2022, 5 (1), pp.800. ⟨10.1038/s42003-022-03760-8⟩

Multidomain kinases use many ways to integrate and process diverse stimuli. Here, we investigated the mechanism by which the protein tyrosine kinase 2-beta (PYK2) functions as a sensor and effector of cellular calcium influx. We show that the linker

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d1c66bb62815768e3b170270e6a16a
https://pubmed.ncbi.nlm.nih.gov/35945264

FAK dimerization controls its kinase-dependent functions at focal adhesions

Autor: Katarzyna W. Walkiewicz, Stefan T. Arold, Álvaro Ortega, Jean-Antoine Girault, Laïla Gasmi, Paul G. Leonard, Nicolas Gervasi, Karen Brami-Cherrier, Gress Kadaré, Bastien Seantier, Diana A. Arsenieva, Marie Claude Boutterin, Tahar Bouceba

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 2014, 33 (4), pp.356-370. ⟨10.1002/embj.201386399⟩
EMBO Journal, 2014, 33 (4), pp.356-370. ⟨10.1002/embj.201386399⟩
The EMBO Journal

International audience; Abstract Focal adhesion kinase (FAK) controls adhesion-dependent cell motility, survival, and proliferation. FAK has kinase-dependent and kinase-independent functions, both of which play major roles in embryogenesis and tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce87f5d4ba2fe387f28c87f98b393147
https://hal.archives-ouvertes.fr/hal-01537170

Ezrin Interacts with Focal Adhesion Kinase and Induces Its Activation Independently of Cell-matrix Adhesion

Autor: Alexis Gautreau, Patrick Poullet, Gress Kadaré, Daniel Louvard, Monique Arpin, Jean-Antoine Girault

Publikováno v: Journal of Biological Chemistry. 276:37686-37691

Ezrin, a membrane-cytoskeleton linker, is required for cell morphogenesis, motility, and survival through molecular mechanisms that remain to be elucidated. Using the N-terminal domain of ezrin as a bait, we found that p125 focal adhesion kinase (FAK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bf5ef14dc466ff829e53b6a459051a
https://doi.org/10.1074/jbc.m106175200

Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons

Autor: Saïd El Messari, Jean-Antoine Girault, Øivind Hvalby, Gress Kadaré, Madeleine Toutant, Vidar Jensen, Jean-Christophe Corvol, Emmanuel Valjent, Jean-Marc Corsi, Camille Faure

Publikováno v: Journal of Cell Science
Journal of Cell Science, 2007, 120 (17), pp.3034-3044. ⟨10.1242/jcs.009613⟩
Journal of Cell Science, Company of Biologists, 2007, 120 (17), pp.3034-3044. ⟨10.1242/jcs.009613⟩

Proline-rich tyrosine kinase 2 (PYK2) is a non-receptor tyrosine kinase expressed in many cell types and enriched in neurons. PYK2 is a cytoplasmic enzyme activated by increases in cytosolic free Ca2+ through an unknown mechanism. We report that depo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8818051967e0d1a355a6341a4c1c52b
https://pubmed.ncbi.nlm.nih.gov/17684059

Alternative splicing controls the mechanisms of FAK autophosphorylation

Autor: Gress Kadaré, Madeleine Toutant, Michèle Carnaud, Jean-Antoine Girault, Alicia Costa, J. M. Studler

Publikováno v: Molecular and cellular biology. 22(22)

Focal adhesion kinase (FAK) is activated following integrin engagement or stimulation of transmembrane receptors. Autophosphorylation of FAK on Tyr-397 is a critical event, allowing binding of Src family kinases and activation of signal transduction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f8f96d76750f522ba381cd71176749
https://pubmed.ncbi.nlm.nih.gov/12391143