MCM double hexamer loading visualized with human proteins.

Autor: Weissmann F; Chromosome Replication Laboratory, The Francis Crick Institute, London, UK., Greiwe JF; Macromolecular Machines Laboratory, The Francis Crick Institute, London, UK., Pühringer T; Macromolecular Machines Laboratory, The Francis Crick Institute, London, UK., Eastwood EL; Chromosome Replication Laboratory, The Francis Crick Institute, London, UK., Couves EC; Macromolecular Machines Laboratory, The Francis Crick Institute, London, UK., Miller TCR; Macromolecular Machines Laboratory, The Francis Crick Institute, London, UK.; DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Diffley JFX; Chromosome Replication Laboratory, The Francis Crick Institute, London, UK. john.diffley@crick.ac.uk., Costa A; Macromolecular Machines Laboratory, The Francis Crick Institute, London, UK. alessandro.costa@crick.ac.uk.

Publikováno v: Nature [Nature] 2024 Dec; Vol. 636 (8042), pp. 499-508. Date of Electronic Publication: 2024 Nov 27.

Unwinding of a eukaryotic origin of replication visualized by cryo-EM.

Autor: Henrikus SS; Macromolecular Machines Laboratory, Francis Crick Institute, London, UK.; Genome Stability Unit, St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia., Gross MH; Chromosome Replication Laboratory, Francis Crick Institute, London, UK., Willhoft O; Macromolecular Machines Laboratory, Francis Crick Institute, London, UK., Pühringer T; Macromolecular Machines Laboratory, Francis Crick Institute, London, UK., Lewis JS; Macromolecular Machines Laboratory, Francis Crick Institute, London, UK., McClure AW; Chromosome Replication Laboratory, Francis Crick Institute, London, UK.; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Greiwe JF; Macromolecular Machines Laboratory, Francis Crick Institute, London, UK., Palm G; Macromolecular Machines Laboratory, Francis Crick Institute, London, UK., Nans A; Structural Biology Science Technology Platform, Francis Crick Institute, London, UK., Diffley JFX; Chromosome Replication Laboratory, Francis Crick Institute, London, UK., Costa A; Macromolecular Machines Laboratory, Francis Crick Institute, London, UK. alessandro.costa@crick.ac.uk.

Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2024 Aug; Vol. 31 (8), pp. 1265-1276. Date of Electronic Publication: 2024 May 17.

In silico reconstitution of DNA replication. Lessons from single-molecule imaging and cryo-tomography applied to single-particle cryo-EM.

Autor: Greiwe JF; Macromolecular Machines Laboratory, The Francis Crick Institute, London NW1 1AT, UK., Zanetti G; Institute of Structural and Molecular Biology, Birkbeck College, Malet St., London WC1E 7HX, UK., Miller TCR; Macromolecular Machines Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark. Electronic address: thomas.miller@crick.ac.uk., Costa A; Macromolecular Machines Laboratory, The Francis Crick Institute, London NW1 1AT, UK. Electronic address: alessandro.costa@crick.ac.uk.

Publikováno v: Current opinion in structural biology [Curr Opin Struct Biol] 2022 Feb; Vol. 72, pp. 279-286. Date of Electronic Publication: 2022 Jan 10.

Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase.

Autor: Greiwe JF; Macromolecular Machines Laboratory, The Francis Crick Institute, London, UK., Miller TCR; Macromolecular Machines Laboratory, The Francis Crick Institute, London, UK.; Center for Chromosome Stability, University of Copenhagen, Copenhagen, Denmark., Locke J; Macromolecular Machines Laboratory, The Francis Crick Institute, London, UK., Martino F; Macromolecular Machines Laboratory, The Francis Crick Institute, London, UK.; Human Technopole, Milan, Italy., Howell S; Proteomics Science Technology Platform, The Francis Crick Institute, London, UK., Schreiber A; Cellular Degradation Systems Laboratory, The Francis Crick Institute, London, UK., Nans A; Structural Biology Science Technology Platform, The Francis Crick Institute, London, UK., Diffley JFX; Chromosome Replication Laboratory, The Francis Crick Institute, London, UK., Costa A; Macromolecular Machines Laboratory, The Francis Crick Institute, London, UK. alessandro.costa@crick.ac.uk.

Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2022 Jan; Vol. 29 (1), pp. 10-20. Date of Electronic Publication: 2021 Dec 28.

TGFβ1 regulates HGF-induced cell migration and hepatocyte growth factor receptor MET expression via C-ets-1 and miR-128-3p in basal-like breast cancer.

Autor: Breunig C; Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany., Erdem N; Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany., Bott A; Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany., Greiwe JF; Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany., Reinz E; Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany., Bernhardt S; Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany., Giacomelli C; Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany., Wachter A; Department of Medical Statistics, University Medical Center, Göttingen, Germany., Kanthelhardt EJ; Department of Gynecology, Martin-Luther-University Halle Wittenberg, Germany., Beißbarth T; Department of Medical Statistics, University Medical Center, Göttingen, Germany., Vetter M; Department of Gynecology, Martin-Luther-University Halle Wittenberg, Germany., Wiemann S; Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Publikováno v: Molecular oncology [Mol Oncol] 2018 Sep; Vol. 12 (9), pp. 1447-1463. Date of Electronic Publication: 2018 Jul 30.