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Phase I and pharmacological study of weekly administration of the polyamine synthesis inhibitor SAM 486A (CGP 48 664) in patients with solid tumors

Autor: Eskens, FALM, Greim, GA, van Zuylen, C, Wolff, [No Value], Denis, LJ, Planting, AST, Muskiet, FA, Barbet, NC, Choi, L, Capdeville, R, Verweij, J, Hanauske, AR, Bruntsch, U

Publikováno v: Clinical Cancer Research, 6(5), 1736-1743. AMER ASSOC CANCER RESEARCH

A single-agent dose-escalating Phase I and pharmacological study of the polyamine synthesis inhibitor SAM 486A was performed. A dosing regimen of four weekly infusions followed by 2 weeks off therapy was studied. Fifty patients were entered into the

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https://research.rug.nl/en/publications/af43ceea-36da-4a6a-8016-bb8dd57ce8d9

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Akademický článek

Phase I and pharmacological study of weekly administration of the polyamine synthesis inhibitor SAM 486A (CGP 48 664) in patients with solid tumors. European Organization for Research and Treatment of Cancer Early Clinical Studies Group.

Autor: Eskens FA; Department of Medical Oncology, Rotterdam Cancer Institute, Daniel den Hoed Kliniek, and University Hospital, The Netherlands. eskens@oncd.azr.nl, Greim GA, van Zuylen C, Wolff I, Denis LJ, Planting AS, Muskiet FA, Wanders J, Barbet NC, Choi L, Capdeville R, Verweij J, Hanauske AR, Bruntsch U

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2000 May; Vol. 6 (5), pp. 1736-43.