Výsledky vyhledávání - "Gregory Zawada"

Application of photoaffinity labeling with [3H] all trans- and 9-cis-retinoic acids for characterization of cellular retinoic acid-binding proteins I and II

Autor: Guangping Chen, Piotr J. Czernik, Gregory Zawada, Victor M. Samokyszyn, Walter E. Gall, Anna Radominska-Pandya, Nadege Terrier, Jacques Magdalou, Joanna M. Little

Publikováno v: Protein Science. 10:200-211

Cellular retinoic acid-binding proteins (CRABPs) are carrier proteins thought to play a crucial role in the transport and metabolism of all-trans-retinoic acid (atRA) and its derivatives within the cell. This report describes a novel photoaffinity-ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e538daa6c5049ae4ac3748da99fae6d6
https://doi.org/10.1110/ps.26501

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4-Hydroxyretinoic Acid, a Novel Substrate for Human Liver Microsomal UDP-glucuronosyltransferase(s) and Recombinant UGT2B7

Autor: Thomas R. Tephly, Anna Radominska-Pandya, Walter E. Gall, Peter I. Mackenzie, Mary Ann Freyaldenhoven, Guangping Chen, Gregory Zawada, Victor M. Samokyszyn

Publikováno v: Journal of Biological Chemistry. 275:6908-6914

It is suggested that formation of more polar metabolites of all-trans-retinoic acid (atRA) via oxidative pathways limits its biological activity. In this report, we investigated the biotransformation of oxidized products of atRA via glucuronidation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4d4f37224f13a88643b432c8f580b1
https://doi.org/10.1074/jbc.275.10.6908

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Differential glucuronidation of bile acids, androgens and estrogens by human UGT1A3 and 2B7

Autor: Mitchell D. Green, Peter I. Mackenzie, Gregory Zawada, Anna Radominska-Pandya, Birgit L. Coffman, Walter E. Gall, Thomas R. Tephly, Behnaz Mojarrabi

Publikováno v: The Journal of steroid biochemistry and molecular biology. 70(1-3)

In this work, UDP-glucuronosyltransferases (UGTs), UGT1A3, 2B7(H268) and 2B7(Y268), stably expressed in human embryonic kidney cells (HK293) were used to assess glucuronidation activities with a variety of steroid hormone and bile acid substrates. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc621ecc4bf8f4a5c38fe777fb660269
https://pubmed.ncbi.nlm.nih.gov/10529008

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