Zobrazeno 1 - 1
of 1
pro vyhledávání: '"Gregory Winterrowd"'
Autor:
John N. Freskos, Yvette M. Fobian, Timothy E. Benson, Michael J. Bienkowski, David L. Brown, Thomas L. Emmons, Robert Heintz, Alice Laborde, Joseph J. McDonald, Brent V. Mischke, John M. Molyneaux, Joseph B. Moon, Patrick B. Mullins, D. Bryan Prince, Donna J. Paddock, Alfredo G. Tomasselli, Gregory Winterrowd
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:73-77
We describe a novel series of potent inhibitors of human beta-secretase. These compounds possess the hydroxyethyl amine transition state isostere. A 2.5A crystal structure of inhibitor 32 bound to BACE is provided.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e643373fd67faba63c23379fdd0447
https://doi.org/10.1016/j.bmcl.2006.09.092
https://doi.org/10.1016/j.bmcl.2006.09.092
