Výsledky vyhledávání - "Gregory Wiens"

Cutting edge: proteasome involvement in the degradation of unassembled Ig light chains

Autor: O'Hare T, Gregory Wiens, Ea, Whitcomb, Ca, Enns, Mb, Rittenberg

Publikováno v: Europe PubMed Central

Several studies on disposal of nonsecreted Ig L chains have identified the endoplasmic reticulum as the site of degradation. Here, we examine degradation of a nonsecreted Ig L chain, T15L, and an experimentally endoplasmic reticulum-retained secretio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::42ee153c1da04996a7f3964be75f17e1
https://pubmed.ncbi.nlm.nih.gov/10384092

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Inefficient assembly and intracellular accumulation of antibodies with mutations in V(H) CDR2

Autor: Tm, Martin, Gregory Wiens, Mb, Rittenberg

Publikováno v: Europe PubMed Central

We previously described secretion defects in four mutants of the murine anti-phosphocholine Ab, T15. The mutant heavy (H) chains had amino acid replacements in the V(H) complementarity-determining region 2 (HCDR2) and were expressed at normal intrace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a644b53629fb00e28bcee27ddcdb843a
https://pubmed.ncbi.nlm.nih.gov/9637510

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Deletion in HCDR3 rescues T15 antibody mutants from a secretion defect caused by mutations in HCDR2

Autor: Tm, Martin, Kowalczyk C, Stevens S, Gregory Wiens, Mp, Stenzel-Poore, Mb, Rittenberg

Publikováno v: Europe PubMed Central

We recently described mutants of the murine anti-phosphocholine Ab T15, with changes in heavy chain complementarity determining region 2 (HCDR2) that caused loss of secretion. Surprisingly, the T15 HCDR2 mutations did not alter secretion when placed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e3a6af63a81e630515c49bc15917e1e8
http://europepmc.org/abstract/med/8906808

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Somatic mutation in VH complementarity-determining region 2 and framework region 2: differential effects on antigen binding and Ig secretion

Autor: Gregory Wiens, Ka, Heldwein, Mp, Stenzel-Poore, Mb, Rittenberg

Publikováno v: Europe PubMed Central

The extent to which somatic mutation impairs the Ig complementarity-determining region (CDR) and framework region (FRW) structure/function is not clear. Previously, we found that the VH CDR2 of the murine T15 Ab is highly sensitive to mutation; 56% (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::559ae1966a0cf708863a34aef434aad4
http://europepmc.org/abstract/med/9233625

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