Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Gregory Wiedman"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/3e765256133c4315b56cf4b2c4d93fc7
Autor:
Ryan P. Ferrie, Cristina R. Ventura, Jenisha Ghimire, Leisheng Sun, Wimley C. Wimley, Eric L. Wu, Shantanu Guha, Kalina Hristova, Gregory Wiedman, Sarah Y. Kim
Publikováno v:
Biochem Pharmacol
Melittin, the main venom component of the European Honeybee, is a cationic linear peptide-amide of 26 amino acid residues with the sequence: GIGAVLKVLTTGLPALISWIKRKRQQ-NH(2). Melittin binds to lipid bilayer membranes, folds into amphipathic α-helica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f2154a0ba8765a05746140a1632f65
https://europepmc.org/articles/PMC9235364/
https://europepmc.org/articles/PMC9235364/
Autor:
Charles Chen, Gregory Wiedman, Jakob P. Ulmschneider, William C. Wimley, Martin B. Ulmschneider, Charles G. Starr, Evan P. Troendle
Publikováno v:
Chen, C H, Starr, C G, Troendle, E, Wiedman, G, Wimley, W C, Ulmschneider, J P & Ulmschneider, M B 2019, ' Simulation-Guided Rational de Novo Design of a Small Pore-Forming Antimicrobial Peptide ', Journal of the American Chemical Society, vol. 141, no. 12, pp. 4839-4848 . https://doi.org/10.1021/jacs.8b11939
In the age of failing small-molecule antibiotics, tapping the near-infinite structural and chemical repertoire of antimicrobial peptides (AMPs) offers one of the most promising routes toward developing next-generation antibacterial compounds. One of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b89a2c7007dd45ab6d65cce14b63dec
https://doi.org/10.1021/jacs.8b11939
https://doi.org/10.1021/jacs.8b11939
Autor:
Gregory Wiedman, Cristina R. Ventura
Publikováno v:
Biochimica et biophysica acta. Biomembranes. 1863(12)
In this article we present the synthesis and characterization of a new form of the membrane active peptide melittin: photomelittin. This peptide was created by substituting the proline residue in melittin for a synthetic azobenzene amino acid derivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202f06223695ab22ee72815eb9dd71f4
https://pubmed.ncbi.nlm.nih.gov/34506797
https://pubmed.ncbi.nlm.nih.gov/34506797
Publikováno v:
Peptide Science. 113
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcef23a8e260849a5f7973dd055e7d87
https://doi.org/10.1002/pep2.24197
https://doi.org/10.1002/pep2.24197
Publikováno v:
Antibiotics, Vol 9, Iss 620, p 620 (2020)
Antibiotics
Antibiotics
Membrane-active peptides (MAPs) have long been thought of as the key to defeating antimicrobial-resistant microorganisms. Such peptides, however, may not be sufficient alone. In this review, we seek to highlight some of the common pathways for resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9fdf0c38a2a6eceaf1340ef9dd05be
https://www.mdpi.com/2079-6382/9/9/620
https://www.mdpi.com/2079-6382/9/9/620
Publikováno v:
Medical Mycology
Fungal keratitis is a leading cause of ocular morbidity and blindness in developing countries. Diagnosing fungal keratitis currently relies on a comparative evaluation of corneal biopsy or scraping using a direct microscopy and culture results. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d14ded0752295a56dcb9593d2a1db7
http://europepmc.org/articles/PMC6186012
http://europepmc.org/articles/PMC6186012
Publikováno v:
mSphere, Vol 3, Iss 6, p e00623-18 (2018)
mSphere
mSphere, Vol 3, Iss 6 (2018)
mSphere
mSphere, Vol 3, Iss 6 (2018)
This work describes an effective assay for TDM of long-chain azole-class antifungal drugs that can be used in diluted human serum samples. This assay will provide a quick, cost-effective method for monitoring concentrations of drugs such as posaconaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4032b1bf49a1b92d384a3a2fd511dc15
https://doaj.org/article/cfc83c9e121d4e2d9b677ef3db199c1e
https://doaj.org/article/cfc83c9e121d4e2d9b677ef3db199c1e
Autor:
Sarah E. Chobot, Bryan A. Fry, P. Leslie Dutton, Christopher C. Moser, Gregory Wiedman, Bohdana M. Discher, Geetha Goparaju
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1857(5):503-512
Here we describe the design, Escherichia coli expression and characterization of a simplified, adaptable and functionally transparent single chain 4-α-helix transmembrane protein frame that binds multiple heme and light activatable porphyrins. Such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d4e7353d5b72c80112e1e852002e6e
Autor:
Kevin J. Hemker, Kalpana Besar, Ionnis J. Kymissis, Kalina Hristova, Gregory Wiedman, Shyuan Yang, Jian Song, Weiguo Huang, Yong Zhang, Yu Liu, Howard E. Katz, Wenmin Guo
Publikováno v:
Advanced functional materials. 25(24)
Printable and fl exible electronics attract sustained attention for their low cost, easy scale up, and potential application in wearable and implantable sensors. However, they are susceptible to scratching, rupture, or other damage from bending or st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b35c6abeed74872fffa1234dcc899a8
https://pubmed.ncbi.nlm.nih.gov/29238288
https://pubmed.ncbi.nlm.nih.gov/29238288