Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gregory W. Hewitt"'
Publikováno v:
The Journal of Organic Chemistry. 70:5781-5789
Four stereoisomers of a Phe-Ala silanediol dipeptide mimic have been evaluated as inhibitors of angiotensin-converting enzyme (ACE) and compared to ketone-based inhibitors reported by Almquist et al. One stereogenic center of the isomers was derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc59801d1c0f8bc20890cfef161765a5
https://doi.org/10.1021/jo048121v
https://doi.org/10.1021/jo048121v
Autor:
Susan Jeffry, Gregory W. Hewitt, Susan Erickson-Viitanen, Ronald M Klabe, Chien-An Chen, Beverly C Cordova, Scott McN. Sieburth, Sena Garber, Athanasios Glekas, George L. Trainor
Publikováno v:
Chemistry & Biology. 8:1161-1166
Background: Silicon is the element most similar to carbon, and bioactive organosilanes have therefore been of longstanding interest. Design of bioactive organosilanes has often involved a systematic replacement of a bioactive molecule's stable carbon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6892f578f4a292fe818a9f9d4de03f82
https://doi.org/10.1016/s1074-5521(01)00079-5
https://doi.org/10.1016/s1074-5521(01)00079-5
Publikováno v:
Tetrahedron Letters. 41:10175-10179
α-Aminosilanes can be readily prepared by rhodium-catalyzed hydrosilylation of Boc-substituted enamines, followed by acidic removal of the Boc group. This convergent approach allows for the rapid synthesis of new aminosilane structures, useful for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a85843288876c0582884b6205179ccd
https://doi.org/10.1016/s0040-4039(00)01827-x
https://doi.org/10.1016/s0040-4039(00)01827-x
Publikováno v:
Applied Organometallic Chemistry. 11:337-343
The readily available aminomethylsilanes can be utilized to prepare the less available α-alkyl-α-aminosilanes. Versatile t-butoxy-carbonal (Boc) derivatives can be metalated between nitrogen and silicon, and then alkylated by an electrophile at thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af3e8698c5184e1d75d86d6571e690d6
https://doi.org/10.1002/(sici)1099-0739(199704)11:4<337::aid-aoc591>3.0.co
https://doi.org/10.1002/(sici)1099-0739(199704)11:4<337::aid-aoc591>3.0.co
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e562dcb1adc7a594fac67c31ec91105b
https://doi.org/10.1002/chin.199737349
https://doi.org/10.1002/chin.199737349
Publikováno v:
ChemInform. 32
α-Aminosilanes can be readily prepared by rhodium-catalyzed hydrosilylation of Boc-substituted enamines, followed by acidic removal of the Boc group. This convergent approach allows for the rapid synthesis of new aminosilane structures, useful for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daa3c2f17effdcc05c24cec3ce6a642a
https://doi.org/10.1002/chin.200115170
https://doi.org/10.1002/chin.200115170