Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Gregory W., SAWYER"'
Publikováno v:
学苑 = Gakuen. 962:8-15
G protein-coupled receptors are cell-surface receptors, many of which have conserved motif F（x）6LL in their C-terminal intracellular region. The motif is known to function when the G protein-coupled receptors are exported from the endoplasmic ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::9f7d67caacbb874e2c89de6bdbefddee
http://id.nii.ac.jp/1203/00006696/
http://id.nii.ac.jp/1203/00006696/
Publikováno v:
European Journal of Pharmacology. 599:36-43
This study presents a direct comparison of the ligand binding and signaling profiles of a mammalian and non-mammalian mu opioid receptor. Opioid ligand binding and agonist potencies were determined for an amphibian (Rana pipiens) mu opioid receptor (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8fa5a55deb90dad71ba0bc6625b8a73
https://doi.org/10.1016/j.ejphar.2008.09.043
https://doi.org/10.1016/j.ejphar.2008.09.043
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 324:196-205
We determined the functional role of a small domain in the third intracellular loop of the human muscarinic M(1) (hM(1)) receptor. Using site-directed mutagenesis, several mutant hM(1) receptors were made possessing either a deletion or point mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3236dca721ee7462a0b3938d8276ed
https://doi.org/10.1124/jpet.107.123695
https://doi.org/10.1124/jpet.107.123695
Autor:
Guodong Li, Gregory W. Sawyer, Jonathan B. Cohen, Richard W. Olsen, David C. Chiara, S. Shaukat Husain
Publikováno v:
The Journal of Neuroscience. 26:11599-11605
General anesthetics, including etomidate, act by binding to and enhancing the function of GABA type A receptors (GABAARs), which mediate inhibitory neurotransmission in the brain. Here, we used a radiolabeled, photoreactive etomidate analog ([3H]azie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425c1bf6e808ef9ff67ceb03be1065f9
https://doi.org/10.1523/jneurosci.3467-06.2006
https://doi.org/10.1523/jneurosci.3467-06.2006
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 53:219-233
Introduction In this study, we used the regulated secretion/aggregation technology (RPD™) to determine the rate of human muscarinic M 1 (hM 1 ) receptor plasma membrane delivery. Methods hM1 receptors were expressed in CHO cells as C-terminal fusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72df4f795369e87002386cc47e8710b2
https://doi.org/10.1016/j.vascn.2005.08.006
https://doi.org/10.1016/j.vascn.2005.08.006
Publikováno v:
Journal of Neurochemistry. 83:1164-1171
The majority of fast inhibitory neurotransmission in the CNS is mediated by the GABA type-A (GABAA) receptor, a ligand-gated chloride channel. Of the approximately 20 different subunits composing the hetero-pentameric GABAA receptor, the γ2 subunit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d59ef6adb470563002e1af33f3e5588
https://doi.org/10.1046/j.1471-4159.2002.01222.x
https://doi.org/10.1046/j.1471-4159.2002.01222.x
Autor:
Gregory W. Sawyer, Frederick J. Ehlert
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781627037785
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::393576efeae7b4c6a948288b957652ca
https://doi.org/10.1007/978-1-62703-779-2_10
https://doi.org/10.1007/978-1-62703-779-2_10
Publikováno v:
British Journal of Pharmacology. 129:1458-1464
1 The muscarinic acetylcholine receptors mediating the contractile response elicited to endogenous acetylcholine released by the selective P2X receptor agonist a,b-methylene ATP (mATP) were investigated in guinea-pig ileum. 2 mATP (0.1‐30 mM) elici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48190e3d298b2f9ba3601d5ea0300f09
https://doi.org/10.1038/sj.bjp.0703180
https://doi.org/10.1038/sj.bjp.0703180
Autor:
Frederick J. Ehlert, Gregory W. Sawyer
Publikováno v:
European Journal of Pharmacology. 367:81-84
We investigated the effects of pertussis toxin on contraction in field-stimulated guinea pig ileum in the absence and presence of isoproterenol. Field-stimulation elicited pertussis toxin-insensitive contractions. Cumulative addition of isoproterenol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150e2edaf7d2141bd7371a711a3d3e72
https://doi.org/10.1016/s0014-2999(99)00002-3
https://doi.org/10.1016/s0014-2999(99)00002-3
Publikováno v:
Life Sciences. 64:387-394
Muscarinic agonists elicit contraction through M3 receptors in most isolated preparations of gastrointestinal smooth muscle, and not surprisingly, several investigators have identified M3 receptors in smooth muscle using biochemical, immunological an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4019f15145e2d73de0af55823be2254
https://doi.org/10.1016/s0024-3205(98)00584-0
https://doi.org/10.1016/s0024-3205(98)00584-0