Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Gregory W, Fisher"'
Autor:
Marcel P. Bruchez, Brigitte F. Schmidt, Lydia A. Perkins, Gregory W. Fisher, Matharishwan Naganbabu, Frederick Mun
Publikováno v:
Molecular Pharmaceutics
The most promising F508del-CFTR corrector, VX-809, has been unsuccessful as an effective, stand-alone treatment for CF patients, but the rescue effect in combination with other drugs may confer an acceptable level of therapeutic benefit. Targeting ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ebbe680813499d3d42e70ce98797ae
http://europepmc.org/articles/PMC5844356
http://europepmc.org/articles/PMC5844356
Autor:
Gregory W. Fisher, Kristine Gouveia, Yang Wu, Shaun R. Stauffer, Alan S. Waggoner, Christopher Szent-Gyorgyi, Annette M. Evangelisti, Mike Poslusney, Cristian Bologa, Larry A. Sklar, Craig W. Lindsley, Anna Waller, Oleg Ursu, Jonathan W. Jarvik, Robyn L. Stanfield, Phillip H. Tapia, J. Jacob Strouse, Mark B. Carter
Publikováno v:
SLAS Discovery. 21:74-87
A new class of biosensors, fluorogen activating proteins (FAPs), has been successfully used to track receptor trafficking in live cells. Unlike the traditional fluorescent proteins (FPs), FAPs do not fluoresce unless bound to their specific small-mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6370374a2170d95abf28784c8d4b965
https://doi.org/10.1177/1087057115609145
https://doi.org/10.1177/1087057115609145
Autor:
Jonathan W. Jarvik, Margaret H. Fuhrman, Marcel P. Bruchez, Gregory W. Fisher, Alan S. Waggoner, Sally A. Adler
Publikováno v:
SLAS Discovery. 15:703-709
Ligand-dependent receptor internalization is a feature of numerous signaling systems. In this article, the authors describe a new kind of live-cell biosensor of receptor internalization that takes advantage of fluorogen-activating protein (FAP) techn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c9375ed35f2606a14df9cee0135659
https://doi.org/10.1177/1087057110370892
https://doi.org/10.1177/1087057110370892
Autor:
Margaret H. Fuhrman, Gregory W. Fisher, Sally A. Adler, Dara Brown, Jonathan W. Jarvik, John P. Holleran
Publikováno v:
Cytometry Part A. :776-782
This study explores the general utility of a new class of biosensor that allows one to selectively visualize molecules of a chosen membrane protein that are at the cell surface. These biosensors make use of recently described bipartite fluoromodules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1549b7e262549dba1b72895b554906e2
https://doi.org/10.1002/cyto.a.20925
https://doi.org/10.1002/cyto.a.20925
Autor:
Christopher, Szent-Gyorgyi, Brigitte F, Schmidt, Brigitte A, Schmidt, Yehuda, Creeger, Gregory W, Fisher, Kelly L, Zakel, Sally, Adler, James A J, Fitzpatrick, Carol A, Woolford, Qi, Yan, Kalin V, Vasilev, Peter B, Berget, Marcel P, Bruchez, Jonathan W, Jarvik, Alan, Waggoner
Publikováno v:
Nature Biotechnology. 26:235-240
Imaging of live cells has been revolutionized by genetically encoded fluorescent probes, most famously green and other fluorescent proteins, but also peptide tags that bind exogenous fluorophores. We report here the development of protein reporters t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98186956edbae54d83b5474050ddfb4
https://doi.org/10.1038/nbt1368
https://doi.org/10.1038/nbt1368
Publikováno v:
Biomaterials. 27:2213-2221
Immobilized patterns of unmodified fibroblast growth factor-2 (FGF-2), with varying surface concentrations, were inkjet printed onto physiologically relevant fibrin substrates. Printed patterns were characterized using iodinated FGF-2 to determine FG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21a0c36e3cc4432647eadcaa41fc9d3
https://doi.org/10.1016/j.biomaterials.2005.10.021
https://doi.org/10.1016/j.biomaterials.2005.10.021
Publikováno v:
Biomaterials. 26:6762-6770
The purpose of this study was to initiate the exploration of cell behavioral responses to inkjet printed spatial patterns of hormones biologically immobilized on biomimetic substrates. This approach was investigated using the example of preosteoblast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11aee170e8f0e86112c5a822d7000136
https://doi.org/10.1016/j.biomaterials.2005.04.032
https://doi.org/10.1016/j.biomaterials.2005.04.032
Autor:
Francesca Sanvito, Claudia Pastori, Assunta Venuti, Gregory W. Fisher, Jonathan W. Jarvik, L. Diomede, Lucia Lopalco, Morgane Bomsel
Publikováno v:
Journal of virology. 88(7)
The chemokine receptor CCR5 is essential for HIV infection and is thus a potential target for vaccine development. However, because CCR5 is a host protein, generation of anti-CCR5 antibodies requires the breaking of immune tolerance and thus carries
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c231d150bcc4d6f4385249f1d2fa447
https://pubmed.ncbi.nlm.nih.gov/24403594
https://pubmed.ncbi.nlm.nih.gov/24403594
Autor:
Nancy T. Ho, Tong-Jian Shen, Ching-Hsuan Tsai, Sandra C. Larson, Gregory W. Fisher, Chien Ho, Ming F. Tam
Publikováno v:
Biochemistry. 40:12169-12177
A recombinant mutant of human fetal hemoglobin (Hb F), named rHb Oscar, has been constructed to explore the importance of the sequence of the amino-terminal region of the gamma-chain to the structural and functional properties of Hb F as compared to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3ef73238fd65e7715d1e97f34e1123
https://doi.org/10.1021/bi0111045
https://doi.org/10.1021/bi0111045
Publikováno v:
Biochemistry. 38:9549-9555
Three recombinant mutants of human fetal hemoglobin (Hb F) have been constructed to determine what effects specific amino acid residues in the gamma chain have on the biophysical and biochemical properties of the native protein molecule. Target resid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14130ffca7ca667c6c422dc86901c537
https://doi.org/10.1021/bi990740o
https://doi.org/10.1021/bi990740o