Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Gregory W, Carter"'
Autor:
Derry C Roopenian, John J Wilson, Jian Wei, Chih-Hao Chang, Sarah E Heuer, Ann E Wells, Gregory W Carter, Colleen Mayberry
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss Suppl 2 (2024)
Externí odkaz:
https://doaj.org/article/5b0024933e1d4f3fab9481a12a9b66f9
Autor:
Gregory A. Cary, Jesse C. Wiley, Jake Gockley, Stephen Keegan, Sai Sruthi Amirtha Ganesh, Laura Heath, Robert R. Butler III, Lara M. Mangravite, Benjamin A. Logsdon, Frank M. Longo, Allan Levey, Anna K. Greenwood, Gregory W. Carter
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION Alzheimer's disease (AD) is the predominant dementia globally, with heterogeneous presentation and penetrance of clinical symptoms, variable presence of mixed pathologies, potential disease subtypes, and numerous associated endo
Externí odkaz:
https://doaj.org/article/87b26c23678e4f5998805f9ff4358f67
Autor:
Lauren Kuffler, Daniel A Skelly, Anne Czechanski, Haley J Fortin, Steven C Munger, Christopher L Baker, Laura G Reinholdt, Gregory W Carter
Publikováno v:
eLife, Vol 12 (2024)
Gene expression is known to be affected by interactions between local genetic variation and DNA accessibility, with the latter organized into three-dimensional chromatin structures. Analyses of these interactions have previously been limited, obscuri
Externí odkaz:
https://doaj.org/article/8a531cdc03ea476dbf2997ce5ddf3035
Autor:
Maria A. Telpoukhovskaia, Thomas J. Murdy, Olivia J. Marola, Kevin Charland, Michael MacLean, Tain Luquez, Alexandra M. Lish, Sarah Neuner, Amy Dunn, Kristen D. Onos, Jesse Wiley, Derek Archer, Matthew J. Huentelman, Matthias Arnold, Vilas Menon, Alison Goate, Linda J. Van Eldik, Paul R. Territo, Gareth R. Howell, Gregory W. Carter, Kristen M. S. O'Connell, Catherine C. Kaczorowski, the 2022 JAX CADR Workshop
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 1, Pp n/a-n/a (2024)
Abstract INTRODUCTION In September 2022, The Jackson Laboratory Center for Alzheimer's and Dementia Research (JAX CADR) hosted a workshop with leading researchers in the Alzheimer's disease and related dementias (ADRD) field. METHODS During the works
Externí odkaz:
https://doaj.org/article/cf95533f4c0f4321bd855f02582741fa
Autor:
Ann E Wells, John J Wilson, Sarah E Heuer, John D Sears, Jian Wei, Raghav Pandey, Mauro W Costa, Catherine C Kaczorowski, Derry C Roopenian, Chih-Hao Chang, Gregory W Carter
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0299595 (2024)
ObjectiveGlycolytic inhibition via 2-deoxy-D-glucose (2DG) has potential therapeutic benefits for a range of diseases, including cancer, epilepsy, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA), and COVID-19, but the systemic effec
Externí odkaz:
https://doaj.org/article/22ce3f406d0c4edab2420289fe6e8a30
Autor:
Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, C Andrew Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory A Cary, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, Emory-Sage-SGC TREAT-AD Center, Alison D Axtman
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0293548 (2024)
RNA sequencing and genetic data support spleen tyrosine kinase (SYK) and high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) as putative targets to be modulated for Alzheimer's disease (AD) therapy. FCER1G is a component of Fc recept
Externí odkaz:
https://doaj.org/article/a694cd69ff044329bed258122700d8e8
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-17 (2023)
Abstract Background Molecular characterization of late-onset Alzheimer’s disease (LOAD), the leading cause of age-related dementia, has revealed transcripts, proteins, and pathway alterations associated with disease. Assessing these postmortem sign
Externí odkaz:
https://doaj.org/article/efde24a7fc5740d399585874539611b4
Autor:
Susan Barendrecht, An Schreurs, Stefanie Geissler, Victor Sabanov, Victoria Ilse, Vera Rieckmann, Rico Eichentopf, Anja Künemund, Benjamin Hietel, Sebastian Wussow, Katrin Hoffmann, Kerstin Körber-Ferl, Ravi Pandey, Gregory W. Carter, Hans-Ulrich Demuth, Max Holzer, Steffen Roßner, Stephan Schilling, Christoph Preuss, Detlef Balschun, Holger Cynis
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-23 (2023)
Abstract Background Hyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallmark of Alzheimer’s disease (AD) brain. Of special interest is the effect of cerebral amyloid beta depositi
Externí odkaz:
https://doaj.org/article/a9c1be2cbfd647cb8dd039ae107ce4ee
Autor:
Stacey J. Sukoff Rizzo, Gregg Homanics, David J. Schaeffer, Lauren Schaeffer, Jung Eun Park, Julia Oluoch, Tingting Zhang, Annat Haber, Nicholas T. Seyfried, Benedict Paten, Anna Greenwood, Takeshi Murai, Sang Ho Choi, Hasi Huhe, Julia Kofler, Peter L. Strick, Gregory W. Carter, Afonso C. Silva
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 3, Pp n/a-n/a (2023)
Abstract Introduction Our limited understanding of the mechanisms that trigger the emergence of Alzheimer's disease (AD) has contributed to the lack of interventions that stop, prevent, or fully treat this disease. We believe that the development of
Externí odkaz:
https://doaj.org/article/6c07eec0388e40f586e42c6bf6451b34
Autor:
Alison D. Axtman, Paul E. Brennan, Tristan Frappier‐Brinton, Ranjita Betarbet, Gregory W. Carter, Haian Fu, Opher Gileadi, Anna K. Greenwood, Karina Leal, Frank M. Longo, Lara M. Mangravite, Aled M. Edwards, Allan I. Levey, The Emory‐Sage‐SGC TREAT‐AD Center
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 2, Pp n/a-n/a (2023)
Abstract Alzheimer's disease (AD) drug discovery has focused on a set of highly studied therapeutic hypotheses, with limited success. The heterogeneous nature of AD processes suggests that a more diverse, systems‐integrated strategy may identify ne
Externí odkaz:
https://doaj.org/article/724635196bb148c28d593f0f387a85ff