Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Gregory V. Kryukov"'
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Somatic mutations are associated with disease, including cancer. Here, the authors analyse cancer genomic data and show that somatic mutations increase with age and that cancer incidence lags 15 years behind this increase, later in life, mutation and
Externí odkaz:
https://doaj.org/article/194930feb5f74d6d8e7f05ca0400f466
Autor:
Andrew L. Hong, Yuen-Yi Tseng, Glenn S. Cowley, Oliver Jonas, Jaime H. Cheah, Bryan D. Kynnap, Mihir B. Doshi, Coyin Oh, Stephanie C. Meyer, Alanna J. Church, Shubhroz Gill, Craig M. Bielski, Paula Keskula, Alma Imamovic, Sara Howell, Gregory V. Kryukov, Paul A. Clemons, Aviad Tsherniak, Francisca Vazquez, Brian D. Crompton, Alykhan F. Shamji, Carlos Rodriguez-Galindo, Katherine A. Janeway, Charles W. M. Roberts, Kimberly Stegmaier, Paul van Hummelen, Michael J. Cima, Robert S. Langer, Levi A. Garraway, Stuart L. Schreiber, David E. Root, William C. Hahn, Jesse S. Boehm
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Identifying therapeutic targets in rare cancers is challenging due to the lack of relevant pre-clinical models. Here, the authors generate a cancer cell line from a paediatric patient with a rare undifferentiated sarcoma and through functional genomi
Externí odkaz:
https://doaj.org/article/a374f09a5d1640b381b40c1ebaec01db
Autor:
Jonathan E. Rosenberg, Levi A. Garraway, Alan D'Andrea, Stacey Gabriel, David B. Solit, Dean F. Bajorin, Toni K. Choueiri, Bernard H. Bochner, Philip Kantoff, Gad Getz, Michael Lawrence, Jesse Boehm, Victor Reuter, Justine A. Barletta, Sabina Signoretti, Angela Qu, Deborah Farlow, Namrata Gupta, Samira Bahl, Richard Bambury, Elizabeth A. Guancial, Jaegil Kim, Ilana Garcia-Grossman, John Sfakianos, Kevin W. O'Connor, Gregory V. Kryukov, Irina Ostrovnaya, Cong Zhu, Hikmat Al-Ahmadie, Nikhil Wagle, Gopa Iyer, Philip Kim, Kent W. Mouw, Eliezer M. Van Allen
Supplementary Figure 1. Mutation rates by cohort. Supplementary Figure 2. ERCC2 mutations. Supplementary Figure 3. ERCC2 mutation status and overall survival. Supplementary Figure 4. ERCC2 mutations occur in highly conserved regions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8792ad3b88aeda063804861e8c6f6416
https://doi.org/10.1158/2159-8290.22530441.v1
https://doi.org/10.1158/2159-8290.22530441.v1
Autor:
Dirk Schadendorf, Levi A. Garraway, Gad Getz, Scott L. Carter, Stacey B. Gabriel, Jessica C. Hassel, Benjamin Weide, Carmen Loquai, Uwe Trefzer, Carola Berking, Friederike Egberts, Helen J. Gogas, Selma Ugurel, Simone M. Goldinger, Ralf Gutzmer, Uwe Hillen, Lisa Zimmer, Deborah Farlow, Kristian Cibulskis, Aaron McKenna, Mara Rosenberg, Eran Hodis, Gregory V. Kryukov, Steven Whittaker, Amaro Taylor-Weiner, Chelsea S. Place, Eva M. Goetz, Cory M. Johannessen, Daniel J. Treacy, Antje Sucker, Nikhil Wagle, Eliezer M. Van Allen
PDF file, 12065K, Supplementary Table S4. Complete listing of all somatic mutations seen in all tumors. This table provides details on every non-synonymous mutation or short insertion/deletion observed in this cohort, with data on genomic coordinates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5506ae088ed88f5f363d9c3bc77d56e0
https://doi.org/10.1158/2159-8290.22530882.v1
https://doi.org/10.1158/2159-8290.22530882.v1
Autor:
Jonathan E. Rosenberg, Levi A. Garraway, Alan D'Andrea, Stacey Gabriel, David B. Solit, Dean F. Bajorin, Toni K. Choueiri, Bernard H. Bochner, Philip Kantoff, Gad Getz, Michael Lawrence, Jesse Boehm, Victor Reuter, Justine A. Barletta, Sabina Signoretti, Angela Qu, Deborah Farlow, Namrata Gupta, Samira Bahl, Richard Bambury, Elizabeth A. Guancial, Jaegil Kim, Ilana Garcia-Grossman, John Sfakianos, Kevin W. O'Connor, Gregory V. Kryukov, Irina Ostrovnaya, Cong Zhu, Hikmat Al-Ahmadie, Nikhil Wagle, Gopa Iyer, Philip Kim, Kent W. Mouw, Eliezer M. Van Allen
Significantly altered genes in clinical subsets. MutSigCV ranked lists for significantly mutated genes in the non-responders only (n = 25), the responders only (n = 25), and the ERCC2WT responders only (n = 16).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d07307f4a0dcf996e6c43fbcf71ea9
https://doi.org/10.1158/2159-8290.22530429
https://doi.org/10.1158/2159-8290.22530429
Autor:
Jonathan E. Rosenberg, Levi A. Garraway, Alan D'Andrea, Stacey Gabriel, David B. Solit, Dean F. Bajorin, Toni K. Choueiri, Bernard H. Bochner, Philip Kantoff, Gad Getz, Michael Lawrence, Jesse Boehm, Victor Reuter, Justine A. Barletta, Sabina Signoretti, Angela Qu, Deborah Farlow, Namrata Gupta, Samira Bahl, Richard Bambury, Elizabeth A. Guancial, Jaegil Kim, Ilana Garcia-Grossman, John Sfakianos, Kevin W. O'Connor, Gregory V. Kryukov, Irina Ostrovnaya, Cong Zhu, Hikmat Al-Ahmadie, Nikhil Wagle, Gopa Iyer, Philip Kim, Kent W. Mouw, Eliezer M. Van Allen
All alterations in responders and non-responders. All somatic mutations and short insertion/deletions are listed, with additional annotations regarding genomic coordinates, protein change, allelic fractions, and validation status (if available).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40133a4082187bb738360e273059e22
https://doi.org/10.1158/2159-8290.22530435.v1
https://doi.org/10.1158/2159-8290.22530435.v1
Autor:
Jonathan E. Rosenberg, Levi A. Garraway, Alan D'Andrea, Stacey Gabriel, David B. Solit, Dean F. Bajorin, Toni K. Choueiri, Bernard H. Bochner, Philip Kantoff, Gad Getz, Michael Lawrence, Jesse Boehm, Victor Reuter, Justine A. Barletta, Sabina Signoretti, Angela Qu, Deborah Farlow, Namrata Gupta, Samira Bahl, Richard Bambury, Elizabeth A. Guancial, Jaegil Kim, Ilana Garcia-Grossman, John Sfakianos, Kevin W. O'Connor, Gregory V. Kryukov, Irina Ostrovnaya, Cong Zhu, Hikmat Al-Ahmadie, Nikhil Wagle, Gopa Iyer, Philip Kim, Kent W. Mouw, Eliezer M. Van Allen
Damaging scores for alterations. This table shows the damaging scores (Methods) for nonsynonymous alterations (missense, nonsense, splice site, frame shift) studied in this cohort. The damaging score was derived as follows: missense mutations were sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91f1091a20cb4acd7244665f0b3b289
https://doi.org/10.1158/2159-8290.22530426.v1
https://doi.org/10.1158/2159-8290.22530426.v1
Autor:
Jonathan E. Rosenberg, Levi A. Garraway, Alan D'Andrea, Stacey Gabriel, David B. Solit, Dean F. Bajorin, Toni K. Choueiri, Bernard H. Bochner, Philip Kantoff, Gad Getz, Michael Lawrence, Jesse Boehm, Victor Reuter, Justine A. Barletta, Sabina Signoretti, Angela Qu, Deborah Farlow, Namrata Gupta, Samira Bahl, Richard Bambury, Elizabeth A. Guancial, Jaegil Kim, Ilana Garcia-Grossman, John Sfakianos, Kevin W. O'Connor, Gregory V. Kryukov, Irina Ostrovnaya, Cong Zhu, Hikmat Al-Ahmadie, Nikhil Wagle, Gopa Iyer, Philip Kim, Kent W. Mouw, Eliezer M. Van Allen
Treatment information and sequencing metrics for all patients The treatment information and raw sequencing metrics, including mean target coverage, for each case is listed here. In addition, the mutation rate data referred to in the Results and repre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334e7c5c1a23aa228e4f0a2210a13b46
https://doi.org/10.1158/2159-8290.22530438.v1
https://doi.org/10.1158/2159-8290.22530438.v1
Autor:
Dirk Schadendorf, Levi A. Garraway, Gad Getz, Scott L. Carter, Stacey B. Gabriel, Jessica C. Hassel, Benjamin Weide, Carmen Loquai, Uwe Trefzer, Carola Berking, Friederike Egberts, Helen J. Gogas, Selma Ugurel, Simone M. Goldinger, Ralf Gutzmer, Uwe Hillen, Lisa Zimmer, Deborah Farlow, Kristian Cibulskis, Aaron McKenna, Mara Rosenberg, Eran Hodis, Gregory V. Kryukov, Steven Whittaker, Amaro Taylor-Weiner, Chelsea S. Place, Eva M. Goetz, Cory M. Johannessen, Daniel J. Treacy, Antje Sucker, Nikhil Wagle, Eliezer M. Van Allen
PDF file 73K, This file contains legends for the five supplementary tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b6cf1ac8c8319d26e53969c1823a5a
https://doi.org/10.1158/2159-8290.22530894.v1
https://doi.org/10.1158/2159-8290.22530894.v1
Autor:
Jonathan E. Rosenberg, Levi A. Garraway, Alan D'Andrea, Stacey Gabriel, David B. Solit, Dean F. Bajorin, Toni K. Choueiri, Bernard H. Bochner, Philip Kantoff, Gad Getz, Michael Lawrence, Jesse Boehm, Victor Reuter, Justine A. Barletta, Sabina Signoretti, Angela Qu, Deborah Farlow, Namrata Gupta, Samira Bahl, Richard Bambury, Elizabeth A. Guancial, Jaegil Kim, Ilana Garcia-Grossman, John Sfakianos, Kevin W. O'Connor, Gregory V. Kryukov, Irina Ostrovnaya, Cong Zhu, Hikmat Al-Ahmadie, Nikhil Wagle, Gopa Iyer, Philip Kim, Kent W. Mouw, Eliezer M. Van Allen
Selective alteration enrichment. This table shows the results of applying Fisher's Exact Test to a tabulated set of predicted damaging somatically altered genes in responders compared to non-responders. A Benjamini-Hochberg/FDR q-value is reported fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686145a458813471867ea00283df35b4
https://doi.org/10.1158/2159-8290.22530423
https://doi.org/10.1158/2159-8290.22530423