Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Gregory V. Barnett"'
Autor:
Magfur E. Alam, Thomas R. Slaney, Peter M. Tessier, Sambit R. Kar, Tapan K. Das, Anthony Leone, Lina Wu, Gregory V. Barnett
Publikováno v:
Journal of Pharmaceutical Sciences. 109:656-669
Monoclonal antibodies are attractive therapeutic agents because of their impressive biological activities and favorable biophysical properties. Nevertheless, antibodies are susceptible to various types of chemical modifications, and the impact of suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c6fa5babbb0da9c5b4dbad6f8496b1
https://doi.org/10.1016/j.xphs.2019.10.051
https://doi.org/10.1016/j.xphs.2019.10.051
Autor:
Marisa K. Joubert, Nathan H. Joh, Linda O. Narhi, Gregory V. Barnett, Nancy Jiao, Twinkle R. Christian, Shawn Cao
Publikováno v:
Journal of Pharmaceutical Sciences. 109:640-645
Subvisible particles (SbVPs) are a critical quality attribute for biotherapeutics. Particle content in prefilled syringes (PFSs) of a biotherapeutic can include protein particles and silicone oil particles (SiOP). Here, a real-world protein therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ca4a3ed083de2b8d99ffde5e740978
https://doi.org/10.1016/j.xphs.2019.10.066
https://doi.org/10.1016/j.xphs.2019.10.066
Publikováno v:
Analytical Chemistry. 90:6959-6966
Methionine oxidation is a major degradation pathway in therapeutic proteins which can impact the structure and function of proteins as well as risk to drug product quality. Detecting Met oxidation in proteins by peptide mapping followed by liquid chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7bbdc30c5eb9434f622d99c3fca7e44
https://doi.org/10.1021/acs.analchem.8b01238
https://doi.org/10.1021/acs.analchem.8b01238
Publikováno v:
The Journal of Physical Chemistry B. 121:5897-5907
Inverse Kirkwood–Buff (KB) solution theory can be used to relate macroscopic quantities with molecular scale interactions and correlation functions, in the form of KB integrals. Protein partial specific volumes (V2) from high-precision density meas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec55efde872d89026472cefb2e936f97
https://doi.org/10.1021/acs.jpcb.7b02553
https://doi.org/10.1021/acs.jpcb.7b02553
Autor:
Tapan K. Das, Gregory V. Barnett, Charles G. Starr, Thomas R. Slaney, Peter M. Tessier, Magfur E. Alam
Publikováno v:
Molecular pharmaceutics. 16(5)
Monoclonal antibodies must be both chemically and physically stable to be developed into safe and effective drugs. Although there has been considerable progress in separately understanding the molecular determinants of antibody chemical and physical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca914dadab981198da28d595f2cc2f2
https://pubmed.ncbi.nlm.nih.gov/30916563
https://pubmed.ncbi.nlm.nih.gov/30916563
Autor:
Yan Gu, Nesredin Mussa, Sergey Voronov, Yuanqi Tao, Julia Ding, Lauren Duhamel, Zheng Jian Li, Gregory V. Barnett
Publikováno v:
Analytical and bioanalytical chemistry. 411(21)
Positive identification of capillary electrophoresis-sodium dodecyl sulfate (CE-SDS) electropherogram peaks provides information to understand protein molecular characteristics at the structural level. It is critical in the design of a robust assay t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84542d9eaa8e987a51974ff552a958b4
https://pubmed.ncbi.nlm.nih.gov/31214752
https://pubmed.ncbi.nlm.nih.gov/31214752
Autor:
Robin Curtis, Steven Blake, Wei Qi, Gregory V. Barnett, Vladimir I. Razinkov, Bruce A. Kerwin, Christopher J. Roberts
Publikováno v:
The Journal of Physical Chemistry B. 120:3318-3330
Preferential interactions of proteins with water and osmolytes play a major role in controlling the thermodynamics of protein solutions. While changes in protein stability and shifts in phase behavior are often reported with the addition of osmolytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dde26f4b7a0e5b65776d914ada57119
https://doi.org/10.1021/acs.jpcb.6b00621
https://doi.org/10.1021/acs.jpcb.6b00621
Autor:
Christopher J. Roberts, Bruce A. Kerwin, Gregory V. Barnett, Alexander Hillsley, Vladimir I. Razinkov
Publikováno v:
Journal of Pharmaceutical Sciences. 105:1066-1073
Controlling and predicting unwanted degradation, such as non-native aggregation, is a long-standing challenge for mAbs and other protein-based products. mAb aggregation rates are typically sensitive to temperature, pH, and the addition of excipients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd4cdde67d3221e433b925a51dda99b
https://doi.org/10.1016/j.xphs.2015.12.017
https://doi.org/10.1016/j.xphs.2015.12.017
Autor:
Tapan K. Das, Thomas R. Slaney, Yunping Huang, Sambit R. Kar, Anthony Leone, Gurusamy Balakrishnan, Li Tao, Gregory V. Barnett, Laurel Hoffman, Jacob Bongers, Naresh Chennamsetty
Publikováno v:
Journal of pharmaceutical sciences. 108(6)
Tryptophan (Trp) oxidation in proteins leads to a number of events, including changes in color, higher order structure (HOS), and biological activity. We describe here a number of new findings through a comprehensive characterization of 6 monoclonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34f0901eb516236eb163329999787c0
https://pubmed.ncbi.nlm.nih.gov/30639740
https://pubmed.ncbi.nlm.nih.gov/30639740
Publikováno v:
Pharmaceutical Research. 35
Characterizing submicron protein particles (approximately 0.1–1μm) is challenging due to a limited number of suitable instruments capable of monitoring a relatively large continuum of particle size and concentration. In this work, we report for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6dc8e50a458fb1bf572d10c37a3d6c0
https://doi.org/10.1007/s11095-017-2306-0
https://doi.org/10.1007/s11095-017-2306-0