Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Gregory T. Motz"'
Autor:
George Coukos, Daniel J. Powell, Melita Irving, Chunsheng Li, Dimitrios Alatzoglou, Gregory T. Motz, Soorin Kim, Stephen P. Santoro
Supplemental Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee30db18ffe48013d2074b02ffc441f
https://doi.org/10.1158/2326-6066.22537117.v1
https://doi.org/10.1158/2326-6066.22537117.v1
Autor:
George Coukos, Daniel J. Powell, Melita Irving, Chunsheng Li, Dimitrios Alatzoglou, Gregory T. Motz, Soorin Kim, Stephen P. Santoro
Figure S1: CAR surface expression tightly correlates with eGFP reporter expression. Figure S2: Bcl-xL induction in response to CAR T-cell activation. Figure S3: PSMA is expressed heterogeneously on tumor blood vessels. Figure S4: P28BBζ T cell-media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c31d1057cd3c6c752834ecaafb2b65b
https://doi.org/10.1158/2326-6066.22537114
https://doi.org/10.1158/2326-6066.22537114
Autor:
George Coukos, Daniel J. Powell, Melita Irving, Chunsheng Li, Dimitrios Alatzoglou, Gregory T. Motz, Soorin Kim, Stephen P. Santoro
Aberrant blood vessels enable tumor growth, provide a barrier to immune infiltration, and serve as a source of protumorigenic signals. Targeting tumor blood vessels for destruction, or tumor vascular disruption therapy, can therefore provide signific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67fce572a2e4f2aa5cd58861ea3612f8
https://doi.org/10.1158/2326-6066.c.6548320.v1
https://doi.org/10.1158/2326-6066.c.6548320.v1
Autor:
George Coukos, Rosemarie Mick, Daniel J. Powell, Drew A. Torigian, Brian J. Czerniecki, Michael Kalos, Bruce L. Levine, Harvey L. Nisenbaum, Lori Smith, Gina M. Mantia-Smaldone, Kathleen Montone, Nikolaos Svoronos, Gregory T. Motz, Andrea R. Hagemann, Janos Tanyi, Lana E. Kandalaft, Cheryl Lai-Lai Chiang
Supplementary Figure S2 - PDF file 84K, Phenotype of DCs following lysate-pulsing (i.e. HOCl-L, UVB-L or FTL), and activation with LPS and IFN-gamma. Unpulsed, mature (mDC) or immature DCs (iDC) served as controls. Data was presented as mean plus-min
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f1ff9d27bf0b3b2d47b6ad36b462f2
https://doi.org/10.1158/1078-0432.22447292.v1
https://doi.org/10.1158/1078-0432.22447292.v1
Autor:
George Coukos, Rosemarie Mick, Daniel J. Powell, Drew A. Torigian, Brian J. Czerniecki, Michael Kalos, Bruce L. Levine, Harvey L. Nisenbaum, Lori Smith, Gina M. Mantia-Smaldone, Kathleen Montone, Nikolaos Svoronos, Gregory T. Motz, Andrea R. Hagemann, Janos Tanyi, Lana E. Kandalaft, Cheryl Lai-Lai Chiang
Supplementary Materials, Methods, Figures and Table legends - PDF file 87K, Supplementary file giving details of supplementary materials and methods, figure legends and table legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f923f4386446ea525ea7321c30f028
https://doi.org/10.1158/1078-0432.22447283.v1
https://doi.org/10.1158/1078-0432.22447283.v1
Autor:
George Coukos, Rosemarie Mick, Daniel J. Powell, Drew A. Torigian, Brian J. Czerniecki, Michael Kalos, Bruce L. Levine, Harvey L. Nisenbaum, Lori Smith, Gina M. Mantia-Smaldone, Kathleen Montone, Nikolaos Svoronos, Gregory T. Motz, Andrea R. Hagemann, Janos Tanyi, Lana E. Kandalaft, Cheryl Lai-Lai Chiang
Supplementary Table S1 - PDF file 191K, Cytokine and chemokine productions from DCs of ovarian cancer subjects that were loaded with HOCl-oxidized autologous whole tumor lysate and matured with LPS and IFN-gamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea66dfd35c14b100fa69edb35bb59b9
https://doi.org/10.1158/1078-0432.22447280.v1
https://doi.org/10.1158/1078-0432.22447280.v1
Autor:
George Coukos, Rosemarie Mick, Daniel J. Powell, Drew A. Torigian, Brian J. Czerniecki, Michael Kalos, Bruce L. Levine, Harvey L. Nisenbaum, Lori Smith, Gina M. Mantia-Smaldone, Kathleen Montone, Nikolaos Svoronos, Gregory T. Motz, Andrea R. Hagemann, Janos Tanyi, Lana E. Kandalaft, Cheryl Lai-Lai Chiang
Purpose: Whole tumor lysates are promising antigen sources for dendritic cell (DC) therapy as they contain many relevant immunogenic epitopes to help prevent tumor escape. Two common methods of tumor lysate preparations are freeze-thaw processing and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015766474701c5816d40b182df9252fc
https://doi.org/10.1158/1078-0432.c.6521027.v1
https://doi.org/10.1158/1078-0432.c.6521027.v1
Autor:
Gregory T. Motz, Fabian Benencia, Li-Ping Wang, Ian S. Hagemann, Stephen Santoro, Priti Lal, George Coukos, Ricardo R. Lastra, Tom Garrabrant, Michael Feldman
Publikováno v:
Nature medicine
We describe a new mechanism regulating the tumor endothelial barrier and T cell infiltration into tumors. We detected selective expression of the death mediator Fas ligand (FasL, also called CD95L) in the vasculature of human and mouse solid tumors b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19863e27baf3b3a676fa6664be980127
https://doi.org/10.1038/nm.3541
https://doi.org/10.1038/nm.3541
Autor:
George Coukos, Gregory T. Motz
Publikováno v:
Immunity, vol. 39, no. 1, pp. 61-73
Generating an anti-tumor immune response is a multi-step process that is executed by effector T cells that can recognize and kill tumor targets. However, tumors employ multiple strategies to attenuate the effectiveness of T cell-mediated attack. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12f8c738a3b0d0afef156e91b5b32da
Publikováno v:
Cancer Research. 72:2162-2171
T-regulatory cells (Tregs) are found infiltrating tumors in a vast array of tumor types, and tumor-infiltrating Tregs are often associated with a poor clinical outcome. Tregs are potent immunosuppressive cells of the immune system that promote progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c198fbe34bbde9e10e6a8ce9e4d0ee82
https://doi.org/10.1158/0008-5472.can-11-3687
https://doi.org/10.1158/0008-5472.can-11-3687