Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Gregory T. Lautenslager"'
Autor:
Clyde W. Shearman, Gregory T. Lautenslager, Fuad N. Ziyadeh, Sheldon Chen, Margo P. Cohen, Elizabeth Hud, Elizabeth Shea
Publikováno v:
Kidney International. 68(4):1554-1561
Evidence linking glycated albumin to altered glomerular nephrin and VEGF expression, proteinuria, and diabetic nephropathy. Background Albumin modified by Amadori-glucose adducts has been linked to the development of diabetic nephropathy through its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d99a77803b7a109915869cfcc0aadbc
Publikováno v:
Metabolism. 50:1435-1440
The diabetic db/db mouse exhibits increased albumin excretion soon after the onset of obesity and hyperglycemia, and later manifests glomerular mesangial matrix expansion resembling that found in human diabetic nephropathy. Since the glomerular lesio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc71b794784d27e6d82c30116a5b0b3
https://doi.org/10.1053/meta.2001.28074
https://doi.org/10.1053/meta.2001.28074
Publikováno v:
Diabetes Care. 24:914-918
OBJECTIVE—Increased albumin excretion in diabetes is believed to be derived from hemodynamic and/or permeability abnormalities, whereas mesangial matrix expansion gives rise to the reduction in glomerular filtration surface and decline in renal fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08591427ac55e85a09f32666a680dfbb
https://doi.org/10.2337/diacare.24.5.914
https://doi.org/10.2337/diacare.24.5.914
Publikováno v:
Kidney International. 59:673-681
Glycated albumin stimulates TGF-βbgr;1 production and protein kinase C activity in glomerular endothelial cells. Background The activation of protein kinase C (PKC) and transforming growth factor-βbgr; (TGF-βbgr;) in glomerular mesangial cells has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd5e572b4af2383c70dc43ae4e88aaf
https://doi.org/10.1046/j.1523-1755.2001.059002673.x
https://doi.org/10.1046/j.1523-1755.2001.059002673.x
Publikováno v:
Metabolism: clinical and experimental. 60(12)
Human serum albumin nonenzymatically condenses with glucose to form stable Amadori adducts that are increased with the hyperglycemia of diabetes. The present study evaluated the influence of fatty acids, which are major endogenous ligands, on albumin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662927dc27ce027d2a5fdc368c20c382
https://pubmed.ncbi.nlm.nih.gov/21632076
https://pubmed.ncbi.nlm.nih.gov/21632076
Publikováno v:
Toxicon. 31:13-26
Experiments were conducted on mouse hemidiaphragm preparations using five phospholipase A2 neurotoxins of differing chain structures and antigenicities [notexin (one chain); crotoxin (two chains not covalently bound), beta-bungarotoxin (two chains co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb63ca6976863873dd719488f4b664c
https://doi.org/10.1016/0041-0101(93)90352-j
https://doi.org/10.1016/0041-0101(93)90352-j
Autor:
Margo P. Cohen, Amy Wang, Sheldon Chen, Gregory T. Lautenslager, Elizabeth Shea, Elizabeth Hud, Clyde W. Shearman
Publikováno v:
American journal of physiology. Renal physiology. 292(2)
Glomerular cells in culture respond to albumin containing Amadori glucose adducts (the principal serum glycated protein), with activation of protein kinase C-β1, increased expression of transforming growth factor (TGF)-β1, the TGF-β type II signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ddc381ba6dd38f0e874c6f7198ea52f
https://pubmed.ncbi.nlm.nih.gov/17018845
https://pubmed.ncbi.nlm.nih.gov/17018845
Publikováno v:
Diabetes technologytherapeutics. 6(3)
Nonenzymatic glycation of apolipoprotein B in the low-density lipoprotein (LDL) complex has been considered a proatherogenic modification contributory to the increased susceptibility of patients with diabetes to atherosclerosis. We postulated that gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af44ea1719952d84ac68f57e5394cdc1
https://pubmed.ncbi.nlm.nih.gov/15198838
https://pubmed.ncbi.nlm.nih.gov/15198838
Publikováno v:
Diabetes care. 24(8)
OBJECTIVE—Whereas increased urinary excretion of type IV collagen, which is believed to reflect renal overproduction of this extracellular matrix protein in early diabetic nephropathy, has been confirmed in several studies, examination of serum con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0bbb102a7314bf0fc99d5b0bc63959
https://pubmed.ncbi.nlm.nih.gov/11473064
https://pubmed.ncbi.nlm.nih.gov/11473064
Publisher Summary A chimeric molecule is an artificial construct in which two or more functional components are linked to form a new and unique biological agent. In the context of this chapter, chimeric molecules can be envisioned as variants on an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54a183997bc269513bb3214d7bf35413
https://doi.org/10.1016/s1569-2558(08)60387-2
https://doi.org/10.1016/s1569-2558(08)60387-2
