Výsledky vyhledávání - "Gregory T. Klus"

Akademický článek

Frequent CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression

Publikováno v: npj Precision Oncology, Vol 8, Iss 1, Pp 1-13 (2024)

Abstract We analyzed genomic data from the prostate cancer of African- and European American men to identify differences contributing to racial disparity of outcome. We also performed FISH-based studies of Chromodomain helicase DNA-binding protein 1

Externí odkaz: https://doaj.org/article/3508a45a6daf4e298c016ff52086528b

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Akademický článek

Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Abstract Due to a demonstrated lack of DNA repair deficiencies, clear cell renal cell carcinoma (ccRCC) has not benefitted from targeted synthetic lethality-based therapies. We investigated whether nucleotide excision repair (NER) deficiency is prese

Externí odkaz: https://doaj.org/article/939969bbc4324201be410156a45cd9e5

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Long-term treatment with the PARP inhibitor niraparib does not increase the mutation load in cell line models and tumour xenografts

Autor: Dávid Szüts, Yonghong Xiao, Gregory T. Klus, Thomas Ried, István Csabai, Keith M. Wilcoxen, Ádám Póti, Zoltan Szallasi, Kinga Berta, Orsolya Pipek, Keith Mikule

Publikováno v: British Journal of Cancer

Background Poly-ADP ribose polymerase (PARP) inhibitor-based cancer therapy selectively targets cells with deficient homologous recombination repair. Considering their long-term use in maintenance treatment, any potential mutagenic effect of PARP inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aceb0f41250d7cffef03ea490230721
https://doi.org/10.1038/s41416-018-0312-6

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Assessing the significance of consistently mis-regulated genes in cancer associated gene expression matrices

Autor: Yi Chen, Zoltan Szallasi, Michael L. Bittner, Mattias Wahde, Gregory T. Klus

Publikováno v: Bioinformatics. 18:389-394

Motivation: The simplest level of statistical analysis of cancer associated gene expression matrices is aimed at finding consistently up- or down-regulated genes within a given set of tumor samples. Considering the high level of gene expression diver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b77ab5952f6feb046fece840f2a3c96
https://doi.org/10.1093/bioinformatics/18.3.389

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Synthesis and in vitro activity of some epimeric 20α-hydroxy, 20-oxime and aziridine pregnene derivatives as inhibitors of human 17α-hydroxylase/c 17,20 -lyase and 5α-reductase

Autor: Yang Liu, Angela Brodie, Gregory T. Klus, Yang-zhi Ling, Xin Wang, Katsuya Kato, Ivo P. Nnane, Kirk Marat, Ji-song Li

Publikováno v: Bioorganic & Medicinal Chemistry. 6:1683-1693

Some epimeric 20-hydroxy, 20-oxime, 16 alpha, 17 alpha-, 17,20- and 20,21-aziridine derivatives of progesterone were synthesized and evaluated as inhibitors of human 17 alpha-hydroxylase/C17,20-lyase (P450(17) alpha) and 5 alpha-reductase (5 alpha-R)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4719200cc4224d1aba3a3797cd942582
https://doi.org/10.1016/s0968-0896(98)00110-2

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Synthesis of novel 21-trifluoropregnane steroids: Inhibitors of 17α-hydroxylase/17,20-lyase (17α-lyase)

Autor: Vincent C. O. Njar, Hausa H. Johnson, Angela Brodie, Gregory T. Klus

Publikováno v: Steroids. 62:468-473

Novel 21-trifluoropregnenolone ( 6 ), 21-trifluoroprogesterone ( 7 ) and related compounds 4a and 8 have been synthesized in high yields from 3β-acetoxyandrost-5-ene-17β-carbaldehyde ( 3 ). The key reaction was the conversion of 3 into the 21-trifl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fa6d596d71ac05decd6b5c765d5a1f
https://doi.org/10.1016/s0039-128x(97)00016-0

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Nucleophilic vinylic 'addition-elimination' substitution reaction of 3β-acetoxy-17-chloro-16-formylandrosta-5,16-diene: A novel and general route to 17-substituted steroids. Part 1 - synthesis of novel 17-azolyl-Δ16 steroids; inhibitors of 17α-hydroxylase/17, 20-lyase (17α-lyase)

Autor: Vincent C. O. Njar, Angela Brodie, Gregory T. Klus

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:2777-2782

We have discovered that chlorine in 3β-acetoxy-17-chloro-16-formylandrosta-5,16-diene (1) can be smoothly displaced by nitrogen heterocyclic nucleophiles (het − ) to give heretofore unknown 17-substituted-Δ 16 steroids in high yields (73–92%).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c79ed230409d7e56b34b477107c8b78f
https://doi.org/10.1016/s0960-894x(96)00512-4

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Down-regulation of the desmosomal cadherin desmocollin 3 in human breast cancer

Autor: Zoltan Szallasi, Dorian M. Korz, Michael L. Bittner, Ari Schick, Saraswati Sukumar, Nina Rokaeus, Yidong Chen, Gregory T. Klus

Publikováno v: Europe PubMed Central

In previous studies using cDNA microarray analysis, we have identified an expressed sequence tag which is consistently down-regulated in six human breast tumor cell lines. In the current study, we have determined this tag to be part of the mRNA seque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89fa3413b38fc13e7f0b741a9a1facb
https://doi.org/10.3892/ijo.19.1.169

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Mutual information analysis as a tool to assess the role of aneuploidy in the generation of cancer-associated differential gene expression patterns

Autor: Zoltan Szallasi, Andrew Song, Ari Schick, Gregory T. Klus, Mattias Wahde

Publikováno v: Europe PubMed Central
Pacific Symposium on Biocomputing

Most human tumors are characterized by: (1) an aberrant set of chromosomes, a state termed aneuploidy; (2) an aberrant gene expression pattern; and (3) an aberrant phenotype of uncontrolled growth. One of the goals of cancer research is to establish

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9233002d0ae3ce3c553ea2b9c57c0244
https://pubmed.ncbi.nlm.nih.gov/11262960

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Sequence-matched probes produce increased cross-platform consistency and more reproducible biological results in microarray-based gene expression measurements

Autor: Zoltan Szallasi, Meena Augustus, Daniel Z. Wetmore, Brigham H. Mecham, David Byrne, Thomas J. Mariani, Isaac S. Kohane, Gregory T. Klus, Jeffrey Strovel, Peter Bozso

Publikováno v: Nucleic Acids Research. 32:e74-e74

Cancer derived microarray data sets are routinely produced by various platforms that are either commercially available or manufactured by academic groups. The fundamental difference in their probe selection strategies holds the promise that identical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52f1461c7febc48049ffbd9ed9960b2
https://doi.org/10.1093/nar/gnh071

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