Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Gregory T Spear"'
Autor:
Elizabeth Daubert, Kathleen M Weber, Audrey L French, Dominika Seidman, Katherine Michel, Deborah Gustafson, Kerry Murphy, Christina A Muzny, Maria Alcaide, Anandi Sheth, Adaora A Adimora, Gregory T Spear
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248136 (2021)
The vaginal microbiota is known to impact women's health, but the biological factors that influence the composition of the microbiota are not fully understood. We previously observed that levels of glycogen in the lumen of the vagina were higher in w
Externí odkaz:
https://doaj.org/article/4ee060678c05493c9a8743a940f4dafa
Autor:
Paria Mirmonsef, Anna L Hotton, Douglas Gilbert, Casey J Gioia, Danijela Maric, Thomas J Hope, Alan L Landay, Gregory T Spear
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153553 (2016)
BACKGROUND:Colonization of the female lower genital tract with Lactobacillus provides protection against STIs and adverse pregnancy outcomes. Growth of genital Lactobacillus is postulated to depend on epithelial cell-produced glycogen. However, the a
Externí odkaz:
https://doaj.org/article/c82e74fd557845259d54b652ad341767
Autor:
M Reza Zariffard, Kathryn Anastos, Audrey L French, Elisaphane Munyazesa, Mardge Cohen, Alan L Landay, Gregory T Spear
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116911 (2015)
OBJECTIVE:Interleukin-8 (IL-8, CXCL8) plays important roles in immune responses at mucosal sites including in the lower genital tract. Since several types of bacteria produce proteases that cleave IL-8 and many types of bacteria can be present in low
Externí odkaz:
https://doaj.org/article/868186bf6e194e39a83bca57aada94c6
Autor:
Lorie Benning, Elizabeth T Golub, Kathryn Anastos, Audrey L French, Mardge Cohen, Douglas Gilbert, Patrick Gillevet, Elisaphane Munyazesa, Alan L Landay, Masoumeh Sikaroodi, Gregory T Spear
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96844 (2014)
Previous studies have shown that alterations of the bacterial microbiota in the lower female genital tract influence susceptibility to HIV infection and shedding. We assessed geographic differences in types of genital microbiota between HIV-infected
Externí odkaz:
https://doaj.org/article/86aebfbfd7744f01afec8f9b1a924c7c
Autor:
Paria Mirmonsef, Anna L Hotton, Douglas Gilbert, Derick Burgad, Alan Landay, Kathleen M Weber, Mardge Cohen, Jacques Ravel, Gregory T Spear
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102467 (2014)
Lactobacillus dominates the lower genital tract microbiota of many women, producing a low vaginal pH, and is important for healthy pregnancy outcomes and protection against several sexually transmitted pathogens. Yet, factors that promote Lactobacill
Externí odkaz:
https://doaj.org/article/08da0eb08194486c8b179c7498e7d401
Autor:
Matthew Brudner, Marshall Karpel, Calli Lear, Li Chen, L Michael Yantosca, Corinne Scully, Ashish Sarraju, Anna Sokolovska, M Reza Zariffard, Damon P Eisen, Bruce A Mungall, Darrell N Kotton, Amel Omari, I-Chueh Huang, Michael Farzan, Kazue Takahashi, Lynda Stuart, Gregory L Stahl, Alan B Ezekowitz, Gregory T Spear, Gene G Olinger, Emmett V Schmidt, Ian C Michelow
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60838 (2013)
Mannose-binding lectin (MBL) is a key soluble effector of the innate immune system that recognizes pathogen-specific surface glycans. Surprisingly, low-producing MBL genetic variants that may predispose children and immunocompromised individuals to i
Externí odkaz:
https://doaj.org/article/bf6071a8ac8d442080d3e3d14a86b618
Autor:
Gregory T Spear, Sabrina R Kendrick, Hua Y Chen, Tin T Thomas, Mieoak Bahk, Robert Balderas, Santosh Ghosh, Aaron Weinberg, Alan L Landay
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19560 (2011)
More than one million new cases of sexually transmitted diseases (STDs) occur each day. The immune responses and inflammation induced by STDs and other frequent non-STD microbial colonizations (i.e. Candida and bacterial vaginosis) can have serious p
Externí odkaz:
https://doaj.org/article/00ded2442ceb4c7f8dfbdcad7a110ba0
Publikováno v:
BioTechniques, Vol 28, Iss 3, Pp 478-486 (2000)
We previously reported that cervicovaginal lavages (CVL) contain a factor that enhances the replication of human immunodefeciency virus (HIV) by increasing virus transcription in T cells and monocytoid cells. This factor was named the HIV-inducing fa
Externí odkaz:
https://doaj.org/article/b8f70fd9e9c342e2a23d90bd32ee5cda
Autor:
Gregory T. Spear, Audrey L. French, Kathleen M. Weber, Christina A. Muzny, Dominika Seidman, Katherine G. Michel, Anandi N. Sheth, Adaora A. Adimora, Elizabeth Daubert, Kerry Murphy, Maria L. Alcaide, Deborah R. Gustafson
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248136 (2021)
PLoS ONE
PLoS ONE
The vaginal microbiota is known to impact women’s health, but the biological factors that influence the composition of the microbiota are not fully understood. We previously observed that levels of glycogen in the lumen of the vagina were higher in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843be517251ed082e06e833a26f98919
https://doaj.org/article/4ee060678c05493c9a8743a940f4dafa
https://doaj.org/article/4ee060678c05493c9a8743a940f4dafa
Autor:
Alan L. Landay, Gregory T. Spear, William W. Spear, Sandra Micci, M. Reza Zariffard, Bruce R. Hamaker, Paria Mirmonsef, Byung-Hoo Lee, Douglas Gilbert, Thomas H. Sullivan, Audrey L. French
Publikováno v:
The Journal of Infectious Diseases. 210:1019-1028
Lactobacillus colonization of the lower female genital tract provides protection from the acquisition of sexually transmitted diseases, including human immunodeficiency virus, and from adverse pregnancy outcomes. While glycogen in vaginal epithelium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a9cf0afc4adbbb1faee2a737495c56
https://doi.org/10.1093/infdis/jiu231
https://doi.org/10.1093/infdis/jiu231