Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Gregory T Booth"'
Autor:
Roberto Lozano, Gregory T Booth, Bilan Yonis Omar, Bo Li, Edward S Buckler, John T Lis, Dunia Pino del Carpio, Jean-Luc Jannink
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 11 (2021)
AbstractControl of gene expression is fundamental at every level of cell function. Promoter-proximal pausing and divergent transcription at promoters and enhancers, which are prominent features in animals, have only been studied in a handful of resea
Externí odkaz:
https://doaj.org/article/7fc33fa6600c4b0488c0d0abcba499f6
Autor:
David F. Read, Gregory T. Booth, Riza M. Daza, Dana L. Jackson, Rula Green Gladden, Sanjay R. Srivatsan, Brent Ewing, Jennifer M. Franks, Cailyn H. Spurrell, Anne Roshella Gomes, Diana O’Day, Aishwarya A. Gogate, Beth K. Martin, Haleigh Larson, Christian Pfleger, Lea Starita, Yiing Lin, Jay Shendure, Shin Lin, Cole Trapnell
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Sex differences and age-related changes in the human heart at the tissue, cell, and molecular level have been well-documented and many may be relevant for cardiovascular disease. However, how molecular programs within individual cell types v
Externí odkaz:
https://doaj.org/article/c78d59de759c46328c8bc8b520ab680e
Autor:
Gregory T. Booth, Riza M. Daza, Sanjay R. Srivatsan, José L. McFaline-Figueroa, Rula Green Gladden, Andrew C. Mullen, Scott N. Furlan, Jay Shendure, Cole Trapnell
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Single-cell chromatin accessibility has emerged as a powerful means of understanding the epigenetic landscape of diverse tissues and cell types, but profiling cells from many independent specimens is challenging and costly. Here we describe
Externí odkaz:
https://doaj.org/article/11167b29a9ec4b1fa5f656373a3275ff
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Promoter-proximal pausing by RNA Pol II is a rate-determining step in gene transcription that is hypothesized to be a prominent point at which regulatory factors act. The pausing factor NELF is known to induce and stabilize pausing, but not
Externí odkaz:
https://doaj.org/article/a4f397b95a1e4d1ab6d474c1a4c11fb7
Autor:
David F Read, Gregory T Booth, Riza M Daza, Dana L Jackson, Rula Green Gladden, Sanjay R Srivatsan, Brent Ewing, Jennifer M Franks, Cailyn H Spurrell, Anne Roshella Gomes, Diana O’Day, Aishwarya A Gogate, Beth K Martin, Lea Starita, Yiing Lin, Jay Shendure, Shin Lin, Cole Trapnell
Sex differences and age-related changes in the human heart at the tissue, cell, and molecular level have been well-documented and many may be relevant for cardiovascular disease. However, how molecular programs within individual cell types vary acros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78a5e2ad749e3c77922df18cb42ac3c8
https://doi.org/10.1101/2022.07.12.496461
https://doi.org/10.1101/2022.07.12.496461
Autor:
Gregory T. Booth, Edward S. Buckler, Jean-Luc Jannink, Bilan Yonis Omar, Dunia Pino Del Carpio, John T. Lis, Bo Li, Roberto Lozano
Publikováno v:
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 11, Iss 11 (2021)
G3: Genes, Genomes, Genetics, Vol 11, Iss 11 (2021)
Control of gene expression is fundamental at every level of cell function. Promoter-proximal pausing and divergent transcription at promoters and enhancers, which are prominent features in animals, have only been studied in a handful of research expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea12df68c9d0ac60cf5be6e757935ea
https://pubmed.ncbi.nlm.nih.gov/34499719
https://pubmed.ncbi.nlm.nih.gov/34499719
Autor:
Tinyi Chu, Gregory T. Booth, H. Hans Salamanca, John T. Lis, Leighton J. Core, Robert John Corona, Charles G. Danko, Sharon L. Longo, Zhong Wang, Hojoong Kwak, Edward J. Rice, Lawrence S. Chin
Publikováno v:
Nature genetics
The human genome encodes a variety of poorly understood RNA species that remain challenging to identify using existing genomic tools. We developed chromatin run-on and sequencing (ChRO-seq) to map the location of RNA polymerase for almost any input s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f382d524229b11dc9834d8ca8fdcb9
http://europepmc.org/articles/PMC6204104
http://europepmc.org/articles/PMC6204104
Autor:
Tin Hang Chong, Ilona Christy Unarta, Yuqing Wang, John T. Lis, Gregory T. Booth, Xuhui Huang, Pak Hang Peter Cheung, Jiguang Wang, Gianmarco Domenico Suarez, Biaobin Jiang
Publikováno v:
Journal of molecular biology. 432(13)
RNA polymerase transcribes certain genomic loci with higher errors rates. These transcription error-enriched genomic loci (TEELs) have implications in disease. Current deep-sequencing methods cannot distinguish TEELs from post-transcriptional modific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5a9ba806490944a883495c0e81b6dc
https://pubmed.ncbi.nlm.nih.gov/32325070
https://pubmed.ncbi.nlm.nih.gov/32325070
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications
Nature Communications
Post-translational modifications of the transcription elongation complex provide mechanisms to fine-tune gene expression, yet their specific impacts on RNA polymerase II regulation remain difficult to ascertain. Here, in Schizosaccharomyces pombe, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2cfffd94eaef086412aff2224e9383
https://doaj.org/article/fcb0fae25f044fe193746041c137258a
https://doaj.org/article/fcb0fae25f044fe193746041c137258a
Autor:
Nathaniel D. Tippens, Colin T. Waters, Noah Dukler, Charles G. Danko, Adam Siepel, John T. Lis, Yi-Fei Huang, Gregory T. Booth
Publikováno v:
Genome Research. 27:1816-1829
Most studies of responses to transcriptional stimuli measure changes in cellular mRNA concentrations. By sequencing nascent RNA instead, it is possible to detect changes in transcription in minutes rather than hours and thereby distinguish primary fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7598188fbb3a001ae678bc726efea1b
https://doi.org/10.1101/gr.222935.117
https://doi.org/10.1101/gr.222935.117