Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Gregory Slobodkin"'
Autor:
Casey Pence, Majed Matar, David Ulkoski, Leslie Wilkinson, Jason G. Fewell, Elaine Brunhoeber, Kirby Wallace, Diane McClure, Gregory Slobodkin, Jennifer Rice, Richard Congo, Angela Rea-Ramsey, Kevin Polach, Jeff Sparks, Khursheed Anwer
Publikováno v:
Journal of Controlled Release. 158:269-276
Exploitation of the RNA interference (RNAi) pathway offers the promise of new and effective therapies for a wide variety of diseases. Clinical development of new drugs based on this platform technology is still limited, however, by a lack of safe and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e747ab08c4767a422cd56f84ba579ae4
https://doi.org/10.1016/j.jconrel.2011.11.006
https://doi.org/10.1016/j.jconrel.2011.11.006
Autor:
Jeanette L. Skoyen, Majed Matar, Jason G. Fewell, Khursheed Anwer, Gregory Slobodkin, Angela Rea-Ramsey, Elaine Brunhoeber, Danny H. Lewis
Publikováno v:
Journal of Biomedical Nanotechnology. 2:53-61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49583f3de7445d6a6709cbb03c8157e0
https://doi.org/10.1166/jbn.2006.002
https://doi.org/10.1166/jbn.2006.002
Autor:
Jennifer Rice, Jason G. Fewell, Gregory Slobodkin, Danny H. Lewis, Khursheed Anwer, Bruce Hovanes, Sang-Oh Han, Majed Matar
Publikováno v:
Journal of Controlled Release. 109:288-298
The synthesis and gene delivery application of a novel lipopolymer, PEG-PEI-CHOL (PPC), is described. PPC is composed of a low molecular weight branched polyethylenimine (PEI) covalently linked with functional groups methoxypolyethyleneglycol (PEG) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8da9241aff1d6000bc614b42f10c980
https://doi.org/10.1016/j.jconrel.2005.09.024
https://doi.org/10.1016/j.jconrel.2005.09.024
Publikováno v:
Tetrahedron Letters. 44:5137-5140
Polycyclic indolic compounds containing the [6,5,6,5,6] ring system were prepared via an intramolecular furan Diels–Alder reaction of α,β-unsaturated amides generated by the N-acylation of 1-(2-furyl)-β-tetrahydrocarbolines. This chemistry can p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d9b91454167af1f5d7b27a2bd39841
https://doi.org/10.1016/s0040-4039(03)01179-1
https://doi.org/10.1016/s0040-4039(03)01179-1
Autor:
Anke Geick, Kerstin Jahn-Hofmann, Monika Krampert, Jennifer Rice, Andrea Schuster, Khursheed Anwer, Richard Congo, Hans-Peter Vornlocher, Gregory Slobodkin, Jason G. Fewell, Diane McClure, Matthias John, Jeff Sparks, Angela Rea-Ramsey, Kevin Polach, Majed Matar, Elaine Brunhoeber
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 20(1)
We have designed a series of versatile lipopolyamines which are amenable to chemical modification for in vivo delivery of small interfering RNA (siRNA). This report focuses on one such lipopolyamine (Staramine), its functionalized derivatives and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4d447681d45dce4a2223b795d8d66a
https://pubmed.ncbi.nlm.nih.gov/21988874
https://pubmed.ncbi.nlm.nih.gov/21988874
Autor:
Andrew D. Hamilton, D. S. Alavi, Robert P. Dixon, David H. Waldeck, Paolo Tecilla, Gregory Slobodkin
Publikováno v:
Journal of the American Chemical Society. 112:9408-9410
Our goal in this work was to develop simple chemical analogues of self-assembly in solution. We sought to link redox or photoactive chromophores to simple hydrogen-bonding subunits. Depending on the complementarity of the binding regions, the subunit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145237556d066aa0b10ce22019786070
https://doi.org/10.1021/ja00181a061
https://doi.org/10.1021/ja00181a061
Autor:
Danny H. Lewis, Jason G. Fewell, Khursheed Anwer, Miranda Worker, Gregory Slobodkin, Casey Pence, Majed Matar, Elaine Brunhoeber, Jennifer Rice
Publikováno v:
The journal of gene medicine. 11(8)
Background The poor prognosis associated with ovarian cancer is primarily the result of delayed diagnosis and the lack of an effective treatment for advanced disease. Use of novel immunotherapy strategies are being evaluated that work to enhance loca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74403b38a3695768904a882c738944a2
https://pubmed.ncbi.nlm.nih.gov/19507172
https://pubmed.ncbi.nlm.nih.gov/19507172
Autor:
Gregory Slobodkin, Andrew D. Hamilton
Publikováno v:
Synthetic Communications. 20:247-251
The reactivity of lithium tetrahyarido-beryllate towards common functional groups is described. The reagent displays a limited reducing ability, less than that of lithium borohydride.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31b76834b1553e893c9e70c23ffe14bf
https://doi.org/10.1080/00397919008052290
https://doi.org/10.1080/00397919008052290
Autor:
David S. Casebier, Carmen M. Baldino, Gregory Slobodkin, Justin Caserta, David L. Coffen, Cheng Tu
Publikováno v:
Synlett. 1997:488-490
The considerable gain in efficiency achievable by introducing the principle of convergence into automated parallel synthesis is illustrated with a seven-step synthesis of a sixteen-hundred-compound array of potential serine protease inhibitors, condu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f28b0f66081ba8441fafa9a59b553e8e
https://doi.org/10.1055/s-1997-6118
https://doi.org/10.1055/s-1997-6118
Autor:
Elaine Brunhoeber, Richard Congo, Gregory Slobodkin, Jennifer Rice, Angela Rea-Ramsey, Khursheed Anwer, Jason G. Fewell, Jeff Sparks, Kevin Polach, Casey Pence, Majed Matar, Diane McClure, Leslie Wilkinson
Publikováno v:
Cancer Research. 71:4995-4995
RNA interference offers the promise of a new class of therapeutics that can specifically target many diseases that have aberrant gene expression as the root cause. This is potentially true even for diseases that are currently considered non-druggable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91d9ec0a1e20c45c4f33682919913987
https://doi.org/10.1158/1538-7445.am2011-4995
https://doi.org/10.1158/1538-7445.am2011-4995