Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gregory Slaybaugh"'
Autor:
Donald M. Engelman, Yana K. Reshetnyak, Dhammika Weerakkody, Gregory Slaybaugh, Oleg A. Andreev
Publikováno v:
Proc Natl Acad Sci U S A
To advance mechanistic understanding of membrane-associated peptide folding and insertion, we have studied the kinetics of three single tryptophan pHLIP (pH-Low Insertion Peptide) variants, where tryptophan residues are located near the N terminus, n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1674a1d8b4bc0e4aea163e86ea4256bb
https://europepmc.org/articles/PMC7275707/
https://europepmc.org/articles/PMC7275707/
Autor:
Gregory Slaybaugh, Michelle L. James, Veronica L. Nagle, Yana K. Reshetnyak, Kelly E. Henry, Aisling Chaney, Keykavous Parang, Haley C. Cropper, Jason S. Lewis, Oleg A. Andreev, Saghar Mozaffari
Publikováno v:
J Nucl Med
Acidosis is a key driver for many diseases, including cancer, sepsis, and stroke. The spatiotemporal dynamics of dysregulated pH across disease remain elusive, and current diagnostic strategies do not provide localization of pH alterations. We sought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579719d2af67e4d2dc1582110c8dcd63
https://pubmed.ncbi.nlm.nih.gov/32005774
https://pubmed.ncbi.nlm.nih.gov/32005774
Autor:
Miguel Machuqueiro, Yana K. Reshetnyak, Gregory Slaybaugh, Diogo Vila-Viçosa, Tomás Silva, Oleg A. Andreev
The pH (low) insertion peptide (pHLIP) is a family of peptides that are able to insert into a lipid bilayer at acidic pH. The molecular mechanism of pHLIPs insertion, folding and stability in the membrane at low pH is based on multiple protonation ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836552e5a6fb2f8eb57421930b6c2c70
https://europepmc.org/articles/PMC6287259/
https://europepmc.org/articles/PMC6287259/
Autor:
Johanna Marie Csengery, Daniel Richard Marshall, Per Hellsund, Ranjit S. Bindra, Oleg A. Andreev, Peter M. Glazer, Yana K. Reshetnyak, Laurie Tylaska, Dhammika Weerakkody, Hanna Visca, Timothy Joseph Paradis, Jane Bechtold, Robert J. Aiello, Vishwas M. Paralkar, Qing Zhang, Donald M. Engelman, Anna Moshnikova, Brett S. Robinson, Gregory Slaybaugh, Patricia Bourassa, Lori Lopresti-Morrow
Publikováno v:
Cancer Research. 79:2981-2981
Poly (ADPribose) polymerase inhibitors (PARPi) have shown great promise in the treatment of cancer, however, their current clinical use has been largely limited to homologous recombination-deficient (HRD) tumors. While these drugs are efficacious as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d14574defd0d4effb1812a40ffd714e4
https://doi.org/10.1158/1538-7445.am2019-2981
https://doi.org/10.1158/1538-7445.am2019-2981
Autor:
Dhammika Weerakkody, Jovana Golijanin, Yana K. Reshetnyak, Keykavous Parang, Naglaa Salem El-Sayed, Rakesh Tiwari, Anna Moshnikova, Ramona Adochite, Oleg A. Andreev, Gregory Slaybaugh
Publikováno v:
Scientific Reports
A series of cyclic peptides containing a number of tryptophan (W) and glutamic acid (E) residues were synthesized and evaluated as pH-sensitive agents for targeting of acidic tissue and pH-dependent cytoplasmic delivery of molecules. Biophysical stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7ea8f5fddf564d2ce41fa7faadec21
https://doi.org/10.1038/srep31322
https://doi.org/10.1038/srep31322
Publikováno v:
Biophysical Journal. 114:245a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8ee94d5728ec7f43b9d97fd886b0739
https://doi.org/10.1016/j.bpj.2017.11.1362
https://doi.org/10.1016/j.bpj.2017.11.1362