Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gregory S. Wirak"'
Publikováno v:
eLife, Vol 11 (2022)
In the aging brain, many of the alterations underlying cognitive and behavioral decline remain opaque. Caenorhabditis elegans offers a powerful model for aging research, with a simple, well-studied nervous system to further our understanding of the c
Externí odkaz:
https://doaj.org/article/5ae94756048d4af69029c81cf5b2a695
Autor:
Erica L Gorenberg, Sofia Massaro Tieze, Betül Yücel, Helen R Zhao, Vicky Chou, Gregory S Wirak, Susumu Tomita, TuKiet T Lam, Sreeganga S Chandra
Publikováno v:
PLoS Biology, Vol 20, Iss 3, p e3001590 (2022)
Loss-of-function mutations in the depalmitoylating enzyme palmitoyl protein thioesterase 1 (PPT1) cause neuronal ceroid lipofuscinosis (NCL), a devastating neurodegenerative disease. The substrates of PPT1 are largely undescribed, posing a limitation
Externí odkaz:
https://doaj.org/article/2b17440e1d874180bbcb43c2eb4e0aab
Publikováno v:
Anesthesiology.
Background Suppression of behavioral and physical responses defines the anesthetized state. This is accompanied, in humans, by characteristic changes in EEG patterns. However, these measures reveal little about the neuron or circuit-level physiologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b910da4282ef4249776ae55f49cb83e2
https://doi.org/10.1097/aln.0000000000004579
https://doi.org/10.1097/aln.0000000000004579
Autor:
Erica L. Gorenberg, Sofia Massaro Tieze, Betül Yücel, Helen R. Zhao, Vicky Chou, Gregory S. Wirak, Susumu Tomita, TuKiet T. Lam, Sreeganga S. Chandra
Publikováno v:
PLoS biology. 20(3)
Loss-of-function mutations in the depalmitoylating enzyme palmitoyl protein thioesterase 1 (PPT1) cause neuronal ceroid lipofuscinosis (NCL), a devastating neurodegenerative disease. The substrates of PPT1 are largely undescribed, posing a limitation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8469c9a14cedf473a333105d98c76191
https://pubmed.ncbi.nlm.nih.gov/35358180
https://pubmed.ncbi.nlm.nih.gov/35358180
Autor:
Erica L. Gorenberg, Susumu Tomita, Betul Yücel, Gregory S. Wirak, Vicky Chou, Sofia M. Tieze, Helen R. Zhao, Sreeganga S. Chandra, TuKiet T. Lam
SUMMARYLoss-of-function mutations in the depalmitoylating enzyme palmitoyl protein thioesterase 1 (PPT1) cause Neuronal Ceroid Lipofuscinosis type 1 (CLN1), a devastating neurodegenerative disease. Here, we provide a resource identifying PPT1 substra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::453f969c5669f4b3e6aa09ef79c9684d
https://doi.org/10.1101/2020.05.02.074302
https://doi.org/10.1101/2020.05.02.074302
Autor:
Peter C G Nijssen, Amy F. Roth, John F. Staropoli, Michael X. Henderson, Gregory S. Wirak, Glyn Dawson, Natalia Dolzhanskaya, TuKiet T. Lam, Sreeganga S. Chandra, Yong-quan Zhang, Stephen D. Ginsberg, Feng Dai, Milen Velinov, Nicholas G. Davis
Publikováno v:
Acta Neuropathologica. 131:621-637
Neuronal ceroid lipofuscinoses (NCL) are a group of inherited neurodegenerative disorders with lysosomal pathology (CLN1-14). Recently, mutations in the DNAJC5/CLN4 gene, which encodes the presynaptic co-chaperone CSPα were shown to cause autosomal-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4507fdd9165f61b3eb1bd3c64d24a949
https://doi.org/10.1007/s00401-015-1512-2
https://doi.org/10.1007/s00401-015-1512-2
Autor:
Gorenberg, Erica L.1,2 (AUTHOR), Massaro Tieze, Sofia1,2 (AUTHOR), Yücel, Betül1 (AUTHOR), Zhao, Helen R.1 (AUTHOR), Chou, Vicky1 (AUTHOR), Wirak, Gregory S.1 (AUTHOR), Tomita, Susumu1,3 (AUTHOR), Lam, TuKiet T.4,5 (AUTHOR), Chandra, Sreeganga S.1 (AUTHOR) sreeganga.chandra@yale.edu
Publikováno v:
PLoS Biology. 3/31/2022, Vol. 20 Issue 3, p1-36. 36p. 1 Color Photograph, 3 Diagrams, 3 Charts, 1 Graph.
Publikováno v:
Multiple Sclerosis Journal; 2023 Suppl 3, Vol. 29, p137-393, 257p
Publikováno v:
Anesthesiology; Jul2023, Vol. 139 Issue 1, p49-62, 14p