Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Gregory S. McElroy"'
Autor:
Nozomu Takata, Jason M. Miska, Marc A. Morgan, Priyam Patel, Leah K. Billingham, Neha Joshi, Matthew J. Schipma, Zachary J. Dumar, Nikita R. Joshi, Alexander V. Misharin, Ryan B. Embry, Luciano Fiore, Peng Gao, Lauren P. Diebold, Gregory S. McElroy, Ali Shilatifard, Navdeep S. Chandel, Guillermo Oliver
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Mammalian retinal metabolism favors aerobic glycolysis. However, the role of glycolytic metabolism in retinal morphogenesis remains unknown. We report that aerobic glycolysis is necessary for the early stages of retinal development. Taking a
Externí odkaz:
https://doaj.org/article/647d9df193e94b6eb9872961ec9b5704
Autor:
Gregory S. McElroy, Ram P. Chakrabarty, Karis B. D’Alessandro, Karthik Vasan, Jerica Tan, Joshua S. Stoolman, Samuel E. Weinberg, Elizabeth M. Steinert, Paul A. Reyfman, Benjamin D. Singer, Warren C. Ladiges, Lin Gao, José Lopéz-Barneo, G. R. Scott Budinger, Navdeep S. Chandel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Aging in mammals leads to reduction in genes encoding the 45-subunit mitochondrial electron transport chain complex I. It has been hypothesized that normal aging and age-related diseases such as Parkinson’s disease are in part due to modes
Externí odkaz:
https://doaj.org/article/60fed24d6ad7416e898540e89de1e6c5
Autor:
Gregory S. McElroy, Ram P. Chakrabarty, Karis B. D’Alessandro, Yuan-Shih Hu, Karthik Vasan, Jerica Tan, Joshua S. Stoolman, Samuel E. Weinberg, Elizabeth M. Steinert, Paul A. Reyfman, Benjamin D. Singer, Warren C. Ladiges, Lin Gao, José Lopéz‑Barneo, Karen Ridge, G. R. Scott Budinger, Navdeep S. Chandel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/bf88894a9fed4d829ae4270cde645adf
Autor:
Ludivine Doridot, Sarah A. Hannou, Sarah A. Krawczyk, Wenxin Tong, Mi-Sung Kim, Gregory S. McElroy, Alan J. Fowler, Inna I. Astapova, Mark A. Herman
Publikováno v:
Nutrients, Vol 13, Iss 10, p 3642 (2021)
The metabolic syndrome (MetS), defined as the co-occurrence of disorders including obesity, dyslipidemia, insulin resistance, and hepatic steatosis, has become increasingly prevalent in the world over recent decades. Dietary and other environmental f
Externí odkaz:
https://doaj.org/article/92e8228cfcdd4b5280730b41525b6866
Autor:
Andrew Shum, Sofia Zaichick, Gregory S. McElroy, Karis D’Alessandro, Milad J. Alasady, Michaela Novakovic, Wesley Peng, Ekaterina A. Grebenik, Daayun Chung, Margaret E. Flanagan, Roger Smith, Alejandro Morales, Laetitia Stumpf, Kaitlyn McGrath, Dimitri Krainc, Marc L. Mendillo, Murali Prakriya, Navdeep S. Chandel, Gabriela Caraveo
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Octopamine is a well-established invertebrate neurotransmitter involved in fight or flight responses. In mammals, its function was replaced by epinephrine. Nevertheless, it is present at trace amounts and can modulate the release of monoamine neurotr
Autor:
Andrew Shum, Sofia Zaichick, Gregory S. McElroy, Karis D’Alessandro, Michaela Novakovic, Wesley Peng, Daayun Chung, Margaret E. Flanagan, Roger Smith, Alejandro Morales, Laetitia Stumpf, Kaitlyn McGrath, Dimitri Krainc, Marc L. Mendillo, Murali Prakriya, Navdeep S. Chandel, Gabriela Caraveo
Octopamine is a well-established invertebrate neurotransmitter involved in fight-or-flight responses. In mammals, its function was replaced by norepinephrine. Nevertheless, it is present at trace amounts and can modulate the release of monoamine neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b3f7497dbd2ad211a865d6b8b07e489
https://doi.org/10.1101/2022.10.04.510813
https://doi.org/10.1101/2022.10.04.510813
Autor:
Navdeep S. Chandel, Marie Werner, Colleen R. Reczek, Inmaculada Martínez-Reyes, G. R. Scott Budinger, Hyewon Kong, Elizabeth M. Steinert, Gregory S. McElroy, Samuel E. Weinberg, Peng Gao, Karthik Vasan, Raul Piseaux, Hermon Kihshen, Luzivette Robles Cardona
Publikováno v:
Nature
The mitochondrial electron transport chain (ETC) is necessary for tumour growth1–6 and its inhibition has demonstrated anti-tumour efficacy in combination with targeted therapies7–9. Furthermore, human brain and lung tumours display robust glucos
Autor:
Ramya Ranganathan, Joseph M. Bateman, Navdeep S. Chandel, Gregory S. McElroy, Lucy Granat, Rachel J. Hunt
Publikováno v:
The Journal of Cell Biology
Hunt et al. show that mitochondrial stress in Drosophila neurons activates ATF4 expression, resulting in increased L-2-hydroxyglutarate (L-2-HG) levels. Reducing L-2-HG levels improves neuronal activity, demonstrating that increased L-2-HG contribute
Autor:
Inna Astapova, Ludivine Doridot, Alan J. Fowler, Wenxin Tong, Mark A. Herman, Sarah A. Krawczyk, Gregory S. McElroy, Misung Kim, Sarah A. Hannou
Publikováno v:
Nutrients
Volume 13
Issue 10
Nutrients, Vol 13, Iss 3642, p 3642 (2021)
Volume 13
Issue 10
Nutrients, Vol 13, Iss 3642, p 3642 (2021)
The metabolic syndrome (MetS), defined as the co-occurrence of disorders including obesity, dyslipidemia, insulin resistance, and hepatic steatosis, has become increasingly prevalent in the world over recent decades. Dietary and other environmental f
Autor:
Timothy C. Wang, Navdeep S. Chandel, Hyewon Kong, Elizabeth M. Steinert, Gregory S. McElroy, Colleen R. Reczek, David M. Sabatini
Publikováno v:
Science Advances
Mitochondrial complex I inhibition in the presence of a mito-antioxidant induces reductive stress, ISR, and cancer cell death.
Mitochondria-derived reactive oxygen species (mROS) are required for the survival, proliferation, and metastasis of ca
Mitochondria-derived reactive oxygen species (mROS) are required for the survival, proliferation, and metastasis of ca