Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Gregory S. Hoeker"'
Autor:
William P. Adams, Tristan B. Raisch, Yajun Zhao, Rafael Davalos, Sarah Barrett, D. Ryan King, Chandra B. Bain, Katrina Colucci-Chang, Grace A. Blair, Alexandra Hanlon, Alicia Lozano, Rengasayee Veeraraghavan, Xiaoping Wan, Isabelle Deschenes, James W. Smyth, Gregory S. Hoeker, Robert G. Gourdie, Steven Poelzing
RationaleCardiac conduction is understood to occur through gap junctions. Recent evidence supports ephaptic coupling as another mechanism of electrical communication in heart. Conduction via gap junctions predicts a direct relationship between conduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eac8fb30b71eac4d9631495700813a9c
https://doi.org/10.1101/2023.05.25.542366
https://doi.org/10.1101/2023.05.25.542366
Autor:
Seth H. Weinberg, Gregory S. Hoeker, D. Ryan King, Steven Poelzing, Grace A. Blair, Xiaobo Wu, Robert G. Gourdie
Publikováno v:
Am J Physiol Heart Circ Physiol
Cardiac voltage-gated sodium channel gain-of-function prolongs repolarization in the long-QT syndrome type 3 (LQT3). Previous studies suggest that narrowing the perinexus within the intercalated disc, leading to rapid sodium depletion, attenuates LQT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940b549b6e15ccf252d850989da3dbd3
https://doi.org/10.1152/ajpheart.00366.2021
https://doi.org/10.1152/ajpheart.00366.2021
Autor:
Rachel L. Padget, Grace A. Blair, Michael D. North, Michael J. Zeitz, Mira T. Tanenbaum, D. Ryan King, Gregory S. Hoeker, Sharon A. Swanger, Steven Poelzing, James W. Smyth
Viral cardiac infection represents a significant clinical challenge encompassing several etiological agents, disease stages, complex presentation, and a resulting lack of mechanistic understanding. Myocarditis is a leading cause of sudden cardiac dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a7ea028652244936366569a5bca86a4
https://doi.org/10.1101/2022.11.29.518421
https://doi.org/10.1101/2022.11.29.518421
Autor:
Rengasayee Veeraraghavan, Gregory S Hoeker, Anita Alvarez-Laviada, Daniel Hoagland, Xiaoping Wan, D Ryan King, Jose Sanchez-Alonso, Chunling Chen, Jane Jourdan, Lori L Isom, Isabelle Deschenes, James W Smyth, Julia Gorelik, Steven Poelzing, Robert G Gourdie
Publikováno v:
eLife, Vol 7 (2018)
Computational modeling indicates that cardiac conduction may involve ephaptic coupling – intercellular communication involving electrochemical signaling across narrow extracellular clefts between cardiomyocytes. We hypothesized that β1(SCN1B) –m
Externí odkaz:
https://doaj.org/article/32935da885304be98d92667cd78158c7
Publikováno v:
Heart Rhythm. 20:S6-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8feeb1a33b0b272270fa008a1f87799e
https://doi.org/10.1016/j.hrthm.2023.03.070
https://doi.org/10.1016/j.hrthm.2023.03.070
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 323(3)
In recent decades, the scientific community has seen an increased interest in rigor and reproducibility. In 2017, concerns about methodological thoroughness and reporting practices were implicated as significant barriers to reproducibility within the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cf57c1029bfeb3d8d03512068d681f
https://pubmed.ncbi.nlm.nih.gov/35749719
https://pubmed.ncbi.nlm.nih.gov/35749719
Autor:
D. Ryan King, Joyce Lin, Michael Entz, Grace A. Blair, Ian Crandell, Gregory S. Hoeker, Steven Poelzing, Alexandra L. Hanlon
Publikováno v:
Pflugers Archiv
Abstract The relationship between cardiac conduction velocity (CV) and extracellular potassium (K+) is biphasic, with modest hyperkalemia increasing CV and severe hyperkalemia slowing CV. Recent studies from our group suggest that elevating extracell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6577cfe477f08fd82060c115a0cb7bd9
http://europepmc.org/articles/PMC7940307
http://europepmc.org/articles/PMC7940307
Autor:
Rachel L. Padget, Grace A. Blair, Michael D. North, D. Ryan King, Michael J. Zeitz, Mira N. Tanenbaum, Gregory S. Hoeker, Sharon A. Swanger, Steven Poelzing, James W. Smyth
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab1a165bc990c1ffcbd1e4a87ed6c0c0
https://doi.org/10.1096/fasebj.2022.36.s1.r6175
https://doi.org/10.1096/fasebj.2022.36.s1.r6175
Autor:
Robert G. Gourdie, James W. Smyth, Carissa C. James, Gregory S. Hoeker, Allison N. Tegge, Steven Poelzing
Publikováno v:
Am J Physiol Heart Circ Physiol
Myocardial ischemia leads to conduction slowing, cell-to-cell uncoupling, and arrhythmias. We previously demonstrated that varying perfusate sodium (Na(+)) and calcium (Ca(2+)) attenuates conduction slowing and arrhythmias during simulated ischemia w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea19bf0c00d0184fb3dbdcc3bf8652a2
https://doi.org/10.1152/ajpheart.00112.2020
https://doi.org/10.1152/ajpheart.00112.2020
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111411 (2014)
Cardioprotection in females, as observed in the setting of heart failure, has been attributed to sex differences in intracellular calcium handling and its modulation by β-adrenergic signaling. However, further studies examining sex differences in β
Externí odkaz:
https://doaj.org/article/f4fa6bc8480547c482c4e540c122e2ab