Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Gregory S. Welmaker"'
Autor:
Renee M. Fleeman, Ginamarie Debevec, Kirsten Antonen, Jessie L. Adams, Radleigh G. Santos, Gregory S. Welmaker, Richard A. Houghten, Marc A. Giulianotti, Lindsey N. Shaw
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
We have previously reported the use of combinatorial chemistry to identify broad-spectrum antibacterial agents. Herein, we extend our analysis of this technology toward the discovery of anti-resistance molecules, focusing on efflux pump inhibitors. U
Externí odkaz:
https://doaj.org/article/809cb367f5204c5297109ac02c5ee8ea
Autor:
Ginamarie Debevec, Radleigh G. Santos, Lindsey N. Shaw, Marc A. Giulianotti, Gregory S. Welmaker, Renee Fleeman, Jessie Adams, Kirsten Antonen, Richard A. Houghten
Publikováno v:
Frontiers in Microbiology
Frontiers in Microbiology, Vol 9 (2018)
Frontiers in Microbiology, Vol 9 (2018)
We have previously reported the use of combinatorial chemistry to identify broad-spectrum antibacterial agents. Herein, we extend our analysis of this technology toward the discovery of anti-resistance molecules, focusing on efflux pump inhibitors. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18cf29d7783fd60d08a9f3d094703bb2
https://doi.org/10.3389/fmicb.2018.01301
https://doi.org/10.3389/fmicb.2018.01301
Autor:
Gregory S. Welmaker, Christopher J. Armishaw, Nurulain T. Zaveri, Marc A. Giulianotti, Andrea Cippitelli, Lawrence Toll, Jinhua Wu, Jennifer Schoch, Gloria Brunori
RATIONALE: Alcoholism is a serious public health problem throughout the world. Current pharmacotherapies for the treatment of this disorder are poorly effective. Preclinical and clinical findings point to nicotinic acetylcholine receptors (nAChRs) as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7abe94206e6ca254734d0482db4cce
https://europepmc.org/articles/PMC5949259/
https://europepmc.org/articles/PMC5949259/
Autor:
Yaohong Zhang, Laura E. Maida, Marc A. Giulianotti, Yongping Yu, Jinhua Wu, Richard A. Houghten, Gregory S. Welmaker, Adel Nefzi, Travis LaVoi, Radleigh G. Santos, Lawrence Toll
Publikováno v:
Journal of Medicinal Chemistry. 56:10103-10117
Nicotine binds to nicotinic acetylcholine receptors (nAChR), which can exist as many different subtypes. The α4β2 nAChR is the most prevalent subtype in the brain and possesses the most evidence linking it to nicotine seeking behavior. Herein we re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1876855e820806863b26bb840ae093
https://doi.org/10.1021/jm401543h
https://doi.org/10.1021/jm401543h
Publikováno v:
The FASEB Journal. 29
Ovarian cancer (OC) is the most lethal gynecological malignancy. OC mortality is associated with a high rate of recurrence (~80%). Recurrent OC is typified by treatment resistant cells; thus, conventional therapies are often ineffective. Therefore, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b1437880223bb4e239c3ca1270eb1a6
https://doi.org/10.1096/fasebj.29.1_supplement.897.21
https://doi.org/10.1096/fasebj.29.1_supplement.897.21
Autor:
Radleigh G. Santos, Renee Fleeman, Adel Nefzi, Travis LaVoi, José L. Medina-Franco, Lindsey N. Shaw, Gregory S. Welmaker, Marc A. Giulianotti, Richard A. Houghten, Angela Morales
Publikováno v:
J Med Chem
Mixture based synthetic combinatorial libraries offer a tremendous enhancement for the rate of drug discovery, allowing the activity of millions of compounds to be assessed through the testing of exponentially fewer samples. In this study we used a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29cd3c07240e9bd8733049db7b34c3e9
https://pubmed.ncbi.nlm.nih.gov/25780985
https://pubmed.ncbi.nlm.nih.gov/25780985
Publikováno v:
Tetrahedron Letters. 50:4807-4809
A simplified approach to the uncatalyzed Paal-Knorr condensation using microwave irradiation in water is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44ef57148f41ac171ac2ac81b37c7419
https://doi.org/10.1016/j.tetlet.2009.06.079
https://doi.org/10.1016/j.tetlet.2009.06.079
Publikováno v:
The Journal of Organic Chemistry. 61:2904-2907
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e7adf1bb2affb3b4d723b633988b98
https://doi.org/10.1021/jo9519975
https://doi.org/10.1021/jo9519975
Publikováno v:
Journal of the American Chemical Society. 117:9139-9150
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9459893e899c8f22409a6863b84c40d
https://doi.org/10.1021/ja00141a004
https://doi.org/10.1021/ja00141a004
Publikováno v:
Drug discovery today. 18(9-10)
Increasing evidence that several drug compounds exert their effects through interactions with multiple targets is boosting the development of research fields that challenge the data reductionism approach. In this article, we review and discuss the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df134e82ffe3cd24085e27375331fb1a
https://pubmed.ncbi.nlm.nih.gov/23340113
https://pubmed.ncbi.nlm.nih.gov/23340113