Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Gregory S Yochum"'
Autor:
Trayambak Pathak, Maxime Gueguinou, Vonn Walter, Celine Delierneux, Martin T Johnson, Xuexin Zhang, Ping Xin, Ryan E Yoast, Scott M Emrich, Gregory S Yochum, Israel Sekler, Walter A Koltun, Donald L Gill, Nadine Hempel, Mohamed Trebak
Publikováno v:
eLife, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/bacfc4e9fb7f4dd8bf3716d520a39baf
Autor:
Trayambak Pathak, Maxime Gueguinou, Vonn Walter, Celine Delierneux, Martin T Johnson, Xuexin Zhang, Ping Xin, Ryan E Yoast, Scott M Emrich, Gregory S Yochum, Israel Sekler, Walter A Koltun, Donald L Gill, Nadine Hempel, Mohamed Trebak
Publikováno v:
eLife, Vol 9 (2020)
Despite the established role of mitochondria in cancer, the mechanisms by which mitochondrial Ca2+ (mtCa2+) regulates tumorigenesis remain incompletely understood. The crucial role of mtCa2+ in tumorigenesis is highlighted by altered expression of pr
Externí odkaz:
https://doaj.org/article/5281232761db416a876d72cbe79942a1
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212850 (2019)
Crohn's disease (CD) is a debilitating inflammatory bowel disease (IBD) that arises from chronic inflammation in the gastrointestinal tract. Genome-wide association studies (GWAS) have identified over 200 single nucleotide polymorphisms (SNPs) that a
Externí odkaz:
https://doaj.org/article/ec3bc7ec53624938b2cc9a5c5966c243
Autor:
Kathleen M Schieffer, Shannon M Bruffy, Richard Rauscher, Walter A Koltun, Gregory S Yochum, Carla J Gallagher
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179267 (2017)
Chronic inflammation associated with inflammatory bowel disease (IBD) results in increased oxidative stress that damages the colonic microenvironment. Low levels of serum bilirubin, an endogenous antioxidant, have been associated with increased risk
Externí odkaz:
https://doaj.org/article/01cc88c63ed54d18b5c0e203141785c3
Autor:
Gregory S Yochum
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18966 (2011)
Inappropriate activation of c-Myc (MYC) gene expression by the Wnt/ß-catenin signaling pathway is required for colorectal carcinogenesis. The elevated MYC levels in colon cancer cells are attributed in part to ß-catenin/TCF4 transcription complexes
Externí odkaz:
https://doaj.org/article/fa8bb4699d4645f9afcebaa610b8ceab
Autor:
Austin C. Portolese, Brittney N. McMullen, Samantha K. Baker, Jeremy R. Chen See, Gregory S. Yochum, Walter A. Koltun, Regina Lamendella, Nimalan A. Jeganathan
Publikováno v:
Diseases of the Colon & Rectum. 66:707-715
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a4937cd56a6857e7eafe58ce484fa29
https://doi.org/10.1097/dcr.0000000000002647
https://doi.org/10.1097/dcr.0000000000002647
Autor:
Xiaojing Zhao, Wenjing Yang, Tianming Yu, Yu Yu, Xiufang Cui, Zheng Zhou, Hui Yang, Yanbo Yu, Anthony J. Bilotta, Suxia Yao, Jimin Xu, Jia Zhou, Gregory S. Yochum, Walter A. Koltun, Austin Portolese, Defu Zeng, Jingwu Xie, Iryna V. Pinchuk, Hongjie Zhang, Yingzi Cong
Publikováno v:
Gastroenterology. 164:89-102
Intestinal fibrosis is a significant complication of Crohn's disease (CD). Gut microbiota reactive Th17 cells are crucial in the pathogenesis of CD; however, how Th17 cells induce intestinal fibrosis is still not completely understood.In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922b87aadd2a20d695dfa91e332d6a61
https://doi.org/10.1053/j.gastro.2022.09.006
https://doi.org/10.1053/j.gastro.2022.09.006
Autor:
Ronaldo Paolo Panganiban, Alyssa Tuan, Maxwell Hart, Mathew Pelton, Daniella Mikhail, Sarah Akhtar, Kaleb Bogale, Susan Deiling, Shouhao Zhou, Mathew D Coates, Gregory S Yochum, Walter Koltun
Publikováno v:
Crohn's & Colitis 360.
Introduction Pyoderma gangrenosum (PG) is a rare, neutrophilic dermatosis that is a well-established extraintestinal manifestation (EIM) of inflammatory bowel disease (IBD). The clinical implications of developing PG in patients with ulcerative colit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a0225828e2ed7ec72a588bf4db33032
https://doi.org/10.1093/crocol/otad024
https://doi.org/10.1093/crocol/otad024
Publikováno v:
Genes
Volume 14
Issue 2
Pages: 481
Volume 14
Issue 2
Pages: 481
Mutations in components of the Wnt/β-catenin signaling pathway drive colorectal cancer (CRC), in part, by deregulating expression of genes controlled by the T-cell factor (TCF) family of transcription factors. TCFs contain a conserved DNA binding do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ac5c84a1e54349cb11f833aa393ab5
Publikováno v:
Journal of Surgical Research. 267:527-535
Background Inflammation of diverticula, which are outpouchings of the colonic bowl wall, causes diverticulitis. Severe cases of diverticulitis require surgical intervention. Through RNA-seq analysis of intestinal tissues, we previously found that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53ba70577d7cf32ec32b4967f39419df
https://doi.org/10.1016/j.jss.2021.06.016
https://doi.org/10.1016/j.jss.2021.06.016