Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Gregory S Yochum"'
Autor:
Trayambak Pathak, Maxime Gueguinou, Vonn Walter, Celine Delierneux, Martin T Johnson, Xuexin Zhang, Ping Xin, Ryan E Yoast, Scott M Emrich, Gregory S Yochum, Israel Sekler, Walter A Koltun, Donald L Gill, Nadine Hempel, Mohamed Trebak
Publikováno v:
eLife, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/bacfc4e9fb7f4dd8bf3716d520a39baf
Autor:
Trayambak Pathak, Maxime Gueguinou, Vonn Walter, Celine Delierneux, Martin T Johnson, Xuexin Zhang, Ping Xin, Ryan E Yoast, Scott M Emrich, Gregory S Yochum, Israel Sekler, Walter A Koltun, Donald L Gill, Nadine Hempel, Mohamed Trebak
Publikováno v:
eLife, Vol 9 (2020)
Despite the established role of mitochondria in cancer, the mechanisms by which mitochondrial Ca2+ (mtCa2+) regulates tumorigenesis remain incompletely understood. The crucial role of mtCa2+ in tumorigenesis is highlighted by altered expression of pr
Externí odkaz:
https://doaj.org/article/5281232761db416a876d72cbe79942a1
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212850 (2019)
Crohn's disease (CD) is a debilitating inflammatory bowel disease (IBD) that arises from chronic inflammation in the gastrointestinal tract. Genome-wide association studies (GWAS) have identified over 200 single nucleotide polymorphisms (SNPs) that a
Externí odkaz:
https://doaj.org/article/ec3bc7ec53624938b2cc9a5c5966c243
Autor:
Kathleen M Schieffer, Shannon M Bruffy, Richard Rauscher, Walter A Koltun, Gregory S Yochum, Carla J Gallagher
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179267 (2017)
Chronic inflammation associated with inflammatory bowel disease (IBD) results in increased oxidative stress that damages the colonic microenvironment. Low levels of serum bilirubin, an endogenous antioxidant, have been associated with increased risk
Externí odkaz:
https://doaj.org/article/01cc88c63ed54d18b5c0e203141785c3
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Dysregulated Wnt/β-catenin signaling is a common feature of colorectal cancer (CRC). The T-cell factor/lymphoid enhancer factor (TCF/LEF; hereafter, TCF) family of transcription factors are critical regulators of Wnt/β-catenin target gene
Externí odkaz:
https://doaj.org/article/3d36c78579c043a784e93cf347046a13
Autor:
Gregory S Yochum
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18966 (2011)
Inappropriate activation of c-Myc (MYC) gene expression by the Wnt/ß-catenin signaling pathway is required for colorectal carcinogenesis. The elevated MYC levels in colon cancer cells are attributed in part to ß-catenin/TCF4 transcription complexes
Externí odkaz:
https://doaj.org/article/fa8bb4699d4645f9afcebaa610b8ceab
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundThe incidence of colorectal cancer (CRC) has been steadily increasing in younger individuals over the past several decades for reasons that are incompletely defined. Identifying differences in gene expression profiles, or transcriptomes, in
Externí odkaz:
https://doaj.org/article/d3d7cbfd3bb3484495bd930968fafa69
Autor:
Francisco Arroyo Almenas, Gábor Törő, Peter Szaniszlo, Manjit Maskey, Ketan K. Thanki, Walter A. Koltun, Gregory S. Yochum, Irina V. Pinchuk, Celia Chao, Mark R. Hellmich, Katalin Módis
Publikováno v:
Antioxidants, Vol 13, Iss 9, p 1067 (2024)
Cystathionine gamma-lyase (CSE) and TNF-α are now recognized as key regulators of intestinal homeostasis, inflammation, and wound healing. In colonic epithelial cells, both molecules have been shown to influence a variety of biological processes, bu
Externí odkaz:
https://doaj.org/article/7455c9bd5d034ec49d339a6ccd807eb1
Autor:
Austin C. Portolese, Brittney N. McMullen, Samantha K. Baker, Jeremy R. Chen See, Gregory S. Yochum, Walter A. Koltun, Regina Lamendella, Nimalan A. Jeganathan
Publikováno v:
Diseases of the Colon & Rectum. 66:707-715
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a4937cd56a6857e7eafe58ce484fa29
https://doi.org/10.1097/dcr.0000000000002647
https://doi.org/10.1097/dcr.0000000000002647
Autor:
Xiaojing Zhao, Wenjing Yang, Tianming Yu, Yu Yu, Xiufang Cui, Zheng Zhou, Hui Yang, Yanbo Yu, Anthony J. Bilotta, Suxia Yao, Jimin Xu, Jia Zhou, Gregory S. Yochum, Walter A. Koltun, Austin Portolese, Defu Zeng, Jingwu Xie, Iryna V. Pinchuk, Hongjie Zhang, Yingzi Cong
Publikováno v:
Gastroenterology. 164:89-102
Intestinal fibrosis is a significant complication of Crohn's disease (CD). Gut microbiota reactive Th17 cells are crucial in the pathogenesis of CD; however, how Th17 cells induce intestinal fibrosis is still not completely understood.In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922b87aadd2a20d695dfa91e332d6a61
https://doi.org/10.1053/j.gastro.2022.09.006
https://doi.org/10.1053/j.gastro.2022.09.006