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pro vyhledávání: '"Gregory S Honda"'
Autor:
Gregory S Honda, Robert G Pearce, Ly L Pham, R W Setzer, Barbara A Wetmore, Nisha S Sipes, Jon Gilbert, Briana Franz, Russell S Thomas, John F Wambaugh
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217564 (2019)
Linking in vitro bioactivity and in vivo toxicity on a dose basis enables the use of high-throughput in vitro assays as an alternative to traditional animal studies. In this study, we evaluated assumptions in the use of a high-throughput, physiologic
Externí odkaz:
https://doaj.org/article/dd304bfaf4ec40dcb06257731d4d94e3
Autor:
Akshay Badrinarayanan, Robert G. Pearce, Jon Gilbert, R. Woodrow Setzer, Barbara A. Wetmore, Derek Angus, Russell S. Thomas, Teresa Sierra, Gregory S. Honda, Roger Dinallo, John F. Wambaugh, Bradley Snodgrass, Chantel I. Nicolas, Chris Strock, Adam Brockman, Caroline Ring
Publikováno v:
Toxicol Sci
High(er) throughput toxicokinetics (HTTK) encompasses in vitro measures of key determinants of chemical toxicokinetics and reverse dosimetry approaches for in vitro-in vivo extrapolation (IVIVE). With HTTK, the bioactivity identified by any in vitro
Autor:
Nisha S. Sipes, Ly Ly Pham, Robert G. Pearce, Jon Gilbert, R. W. Setzer, Russell S. Thomas, Gregory S. Honda, John F. Wambaugh, Briana Franz, Barbara A. Wetmore
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0217564 (2019)
PLoS ONE, Vol 14, Iss 5, p e0217564 (2019)
Linking in vitro bioactivity and in vivo toxicity on a dose basis enables the use of high-throughput in vitro assays as an alternative to traditional animal studies. In this study, we evaluated assumptions in the use of a high-throughput, physiologic
Publikováno v:
Chemical Engineering Journal. 285:402-408
The hydrodynamics of trickle bed reactors operating near the trickle-bubbly flow regime transition have not been fully characterized in the literature. In this work, an air–water system is used to investigate the effects of particle size, particle
Autor:
R. Woodrow Setzer, Barbara A. Wetmore, John F. Wambaugh, Russell S. Thomas, Risa Sayre, Gregory S. Honda, Katie Paul Friedman, Robert G. Pearce
Publikováno v:
ISEE Conference Abstracts. 2018
Toxicokinetics (TK) is required information for chemical risk assessment. Unfortunately, TK data are not available for most chemicals in commerce and the environment. New approach methodologies (NA...
Publikováno v:
Industrial & Engineering Chemistry Research. 54:10253-10259
The transitions from trickle to bubbly flow and trickle to pulsing flow are investigated in the range of gas superficial velocities vG = 4–220 mm/s using air and water, with additional consideration of the effect of the prewetting procedure. The fl
Publikováno v:
Industrial & Engineering Chemistry Research. 53:9027-9034
Characterization of the hydrodynamics enables operation of trickle bed reactors within the desired flow regime and under conditions for uniform distribution of gas and liquid, resulting in an essentially plug flow contacting pattern. Studies reported
Autor:
Gregory S. Honda, Benjamin A. Wilhite
Publikováno v:
Chemical Engineering Science. 68:663-667
Microreactors employing thin catalytic films present a unique situation in catalyst design owing to the removal of symmetric internal boundary condition (i.e. zero heat flux) employed in catalyst design analysis to-date. The allowance for substantial