Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Gregory S, Whitehead"'
Autor:
Gentaro Izumi, Hideki Nakano, Keiko Nakano, Gregory S. Whitehead, Sara A. Grimm, Michael B. Fessler, Peer W. Karmaus, Donald N. Cook
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Dendritic cells in the lung may be specialised to mediate specific types of immune function. Here the authors show that subpopulations of mouse CD11b+ lung DC at different stages of maturation and phenotype can promote Th17 or Th2 CD4+ T cell differe
Externí odkaz:
https://doaj.org/article/2d7e7a34ad9741c7b9cd97853b90ab3b
Autor:
Gregory S. Whitehead, Seddon Y. Thomas, Keiko Nakano, Derek J. Royer, Catherine G. Burke, Hideki Nakano, Donald N. Cook
Publikováno v:
JCI Insight, Vol 7, Iss 4 (2022)
The intensity and longevity of inflammatory responses to inhaled allergens is determined largely by the balance between effector and regulatory immune responses, but the mechanisms that determine the relative magnitudes of these opposing forces remai
Externí odkaz:
https://doaj.org/article/68c891eaece8469ca1404ec09b7ac379
Autor:
Zhiwei, Wen, Veronica, Salmaso, Young-Hwan, Jung, Ngan B, Phung, Varun, Gopinatth, Qasim, Shah, Alexandra T, Patterson, John C R, Randle, Zhoumou, Chen, Daniela, Salvemini, David I, Lieberman, Gregory S, Whitehead, Tadeusz P, Karcz, Donald N, Cook, Kenneth A, Jacobson
Publikováno v:
J Med Chem
High affinity phenyl-piperidine P2Y(14)R antagonist 1 (PPTN) was modified with piperidine bridging moieties to probe receptor affinity and hydrophobicity. Various 2-azanorbornane, nortropane, isonortropane, isoquinuclidine, and ring-opened cyclopenty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da62c41535c927994c70d1b42266cae7
https://pubmed.ncbi.nlm.nih.gov/35113556
https://pubmed.ncbi.nlm.nih.gov/35113556
Autor:
Gregory S. Whitehead, Donald N. Cook, R Fannin, Cynthia L. Innes, Stavros Garantziotis, Carol S. Trempus, Salik Hussain, Shepherd H. Schurman
Publikováno v:
Lung
INTRODUCTION: Innate immune activation through exposure to indoor and outdoor pollutants is emerging as an important determinant of asthma severity. For example, household levels of the bacterial product lipopolysaccharide (LPS) are associated with i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90303d19b6743e24231b3c648ec1bb6
https://doi.org/10.1007/s00408-020-00337-2
https://doi.org/10.1007/s00408-020-00337-2
Autor:
Zhiwei Wen, Veronica Salmaso, Young-Hwan Jung, Ngan B. Phung, Varun Gopinatth, Qasim Shah, Alexandra T. Patterson, John C. R. Randle, Zhoumou Chen, Daniela Salvemini, David I. Lieberman, Gregory S. Whitehead, Tadeusz P. Karcz, Donald N. Cook, Kenneth A. Jacobson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a16138dcf66e0cf8b0d97c43fac4e0
http://hdl.handle.net/11577/3459804
http://hdl.handle.net/11577/3459804
Autor:
Gregory S. Whitehead, Tadeusz P. Karcz, Dilip K. Tosh, Young-Hwan Jung, Zhiwei Wen, Ryan G. Campbell, Varun Gopinatth, Zhan-Guo Gao, Kenneth A. Jacobson, Donald N. Cook
COVID-19 disease is associated with progressive accumulation of SARS-CoV-2-specific mRNA, which is recognized by innate immune receptors, such as TLR3. This in turn leads to dysregulated production of multiple cytokines, including IL-6, IFN-γ, CXCL1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ddab2d317b599110bf79f6e32515bd8
https://ruj.uj.edu.pl/xmlui/handle/item/303815
https://ruj.uj.edu.pl/xmlui/handle/item/303815
Autor:
Keiko Nakano, Peer W. F. Karmaus, Michael B. Fessler, Hideki Nakano, Sara A. Grimm, Donald N. Cook, Gentaro Izumi, Gregory S. Whitehead
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Dendritic cells (DC) in the lung that induce Th17 differentiation remain incompletely understood, in part because conventional CD11b+ DCs (cDC2) are heterogeneous. Here, we report a population of cDCs that rapidly accumulates in lungs of mice followi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738648b034bb635090fccc3eaff6ceb2
https://doi.org/10.1038/s41467-021-25307-x
https://doi.org/10.1038/s41467-021-25307-x
Autor:
Gregory S. Whitehead, Seddon Y. Thomas, Keiko Nakano, Derek J. Royer, Catherine G. Burke, Hideki Nakano, Donald N. Cook
Publikováno v:
JCI insight. 7(4)
The intensity and longevity of inflammatory responses to inhaled allergens is determined largely by the balance between effector and regulatory immune responses, but the mechanisms that determine the relative magnitudes of these opposing forces remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a16448a6a449937f5e4c29af62ba20
https://pubmed.ncbi.nlm.nih.gov/35191395
https://pubmed.ncbi.nlm.nih.gov/35191395
Autor:
Leesa J. Deterding, Sara A. Grimm, Donald N. Cook, Jason Williams, Gregory S. Whitehead, Tadeusz P Karcz, Keiko Nakano, Hideki Nakano, Kenneth A. Jacobson
Publikováno v:
J Clin Invest
Airway eosinophilia is a hallmark of allergic asthma and is associated with mucus production, airway hyperresponsiveness, and shortness of breath. Although glucocorticoids are widely used to treat asthma, their prolonged use is associated with severa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3aa73acd8bf5689d23ffa4c3f65510
https://europepmc.org/articles/PMC8011887/
https://europepmc.org/articles/PMC8011887/
Autor:
Gentaro, Izumi, Hideki, Nakano, Keiko, Nakano, Gregory S, Whitehead, Sara A, Grimm, Michael B, Fessler, Peer W, Karmaus, Donald N, Cook
Publikováno v:
Nature Communications
Dendritic cells (DC) in the lung that induce Th17 differentiation remain incompletely understood, in part because conventional CD11b+ DCs (cDC2) are heterogeneous. Here, we report a population of cDCs that rapidly accumulates in lungs of mice followi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0eaa1e8d32bcb346f8a3966930615e65
https://pubmed.ncbi.nlm.nih.gov/34413303
https://pubmed.ncbi.nlm.nih.gov/34413303