Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gregory R. Robbins"'
Autor:
Hee Jeung Oh, Mariam S. Aboian, Michael Y. J. Yi, Jacqueline A. Maslyn, Whitney S. Loo, Xi Jiang, Dilworth Y. Parkinson, Mark W. Wilson, Terilyn Moore, Colin R. Yee, Gregory R. Robbins, Florian M. Barth, Joseph M. DeSimone, Steven W. Hetts, Nitash P. Balsara
Publikováno v:
ACS Central Science, Vol 5, Iss 3, Pp 419-427 (2019)
Externí odkaz:
https://doaj.org/article/3515ce85610e4057823d1a4cd31dd093
Autor:
Nitash P. Balsara, Steven W. Hetts, Jacqueline A. Maslyn, Gregory R. Robbins, Mariam Aboian, Hee Jeung Oh, Michael Y. J. Yi, Florian M. Barth, T Moore, Dilworth Y. Parkinson, Joseph M. DeSimone, Colin Yee, Whitney S. Loo, Xi Jiang, Mark W. Wilson
Publikováno v:
ACS Central Science, Vol 5, Iss 3, Pp 419-427 (2019)
ACS central science, vol 5, iss 3
ACS central science, vol 5, iss 3
Despite efforts to develop increasingly targeted and personalized cancer therapeutics, dosing of drugs in cancer chemotherapy is limited by systemic toxic side effects. We have designed, built, and deployed porous absorbers for capturing chemotherapy
Autor:
Tojan B. Rahhal, Marc P. Kai, J. Christopher Luft, Joseph M. DeSimone, Gregory R. Robbins, Tammy W. Shen, Catherine A. Fromen
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 12:677-687
Engineered nanoparticles have the potential to expand the breadth of pulmonary therapeutics, especially as respiratory vaccines. Notably, cationic nanoparticles have been demonstrated to produce superior local immune responses following pulmonary del
Publikováno v:
Molecular Cell. 54(2):297-308
Modern medical and hygienic practices have greatly improved human health and longevity; however, increased human life span occurs concomitantly with the emergence of metabolic and age-related diseases. Studies over the past decade have strongly linke
Autor:
Agnieszka D. Truax, Beckley K. Davis, Jenny P.-Y. Ting, W. June Brickey, Gregory R. Robbins, Lu Zhang
Publikováno v:
Journal of Biological Chemistry. 287:24294-24303
Most of the nucleotide-binding domain, leucine-rich repeat (NLR) proteins regulate responses to microbial and damage-associated products. Class II transactivator (CIITA) has a distinct function as the master regulator of class II major histocompatibi
Autor:
William C. Zamboni, J. Christopher Luft, James E. Bear, Amanda W. Keeler, Gregory R. Robbins, Tammy W. Shen, Joseph M. DeSimone, Marc P. Kai, Jenny P.-Y. Ting, Hailey E. Brighton, Yancey E. Luft, Catherine A. Fromen
Long-circulating nanoparticles are essential for increasing tumor accumulation to provide therapeutic efficacy. While it is known that tumor presence can alter the immune system, very few studies have explored this impact on nanoparticle circulation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370797cda979d757d3d45a62f1ed7f9d
https://europepmc.org/articles/PMC4761267/
https://europepmc.org/articles/PMC4761267/
Autor:
Gregory R. Robbins, J. Christopher Luft, Marc P. Kai, Tojan B. Rahhal, Joseph M. DeSimone, Tammy W. Shen, Catherine A. Fromen
Publikováno v:
Pharmaceutical research. 32(10)
We evaluated the role of a poly(ethylene glycol) (PEG) surface coating to increase residence times and alter the cellular fate of nano- and microparticles delivered to the lung. Three sizes of PRINT hydrogel particles (80 × 320 nm, 1.5 and 6 μm don
Autor:
Jenny P.-Y. Ting, Gregory R. Robbins, Joseph M. DeSimone, Marc P. Kai, Catherine A. Fromen, Tammy W. Shen
Pulmonary immunization enhances local humoral and cell-mediated mucosal protection, which are critical for vaccination against lung-specific pathogens such as influenza or tuberculosis. A variety of nanoparticle (NP) formulations have been tested pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908d291215bae65d5fb0a48fe6494fc8
Autor:
Joseph M. DeSimone, Lishan Su, Karen P. McKinnon, Gregory D. Sempowski, Tammy W. Shen, Reid A. Roberts, Haitao Guo, Kevin G. Reuter, Gregory R. Robbins, Jenny P.-Y. Ting
Ideal nanoparticle (NP)-based drug and vaccine delivery vectors should be free of inherent cytotoxic or immunostimulatory properties. Therefore, determining baseline immune responses to nanomaterials is of utmost importance when designing human thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce65118ff458384ac692b20af051170d
Autor:
Gregory R. Robbins, Denis Gris, Yoshitaka Oyama, Timothy K. Eitas, Jenny P.-Y. Ting, June Brickey, Haitao Wen, Wei-Chun Chou
The nucleotide binding domain and leucine-rich repeat-containing (NLR) family of proteins is known to activate innate immunity, and the inflammasome-associated NLRs are prime examples. In contrast, the concept that NLRs can inhibit innate immunity is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912ae830951edfbc881c6e7bbe704944