Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Gregory R. Ferrier"'
Autor:
Howlett SE; Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada. Susan.Howlett@Dal.ca
Publikováno v:
Heart rhythm [Heart Rhythm] 2006 Apr; Vol. 3 (4), pp. 497.
Autor:
Susan E. Howlett
Publikováno v:
Heart Rhythm. 3:497
Autor:
Susan E. Howlett, Gregory R. Ferrier
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 313:823-830
It is not clear whether activation of ATP-sensitive potassium channels (K(ATP)) with pinacidil in advance of ischemia and reperfusion promotes or suppresses arrhythmias. This study determines the effects of pinacidil pretreatment on arrhythmias and t
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 310:761-773
This study investigates whether amrinone (100-1000 microM), a phosphodiesterase-III inhibitor, can alleviate depression of contractions in ventricular myocytes from prefailure cardiomyopathic (CM) hamsters (80-100 days). Cell shortening and ion curre
Publikováno v:
European Journal of Pharmacology. 476:45-54
We determined effects of the nitric oxide (NO) precursor L-arginine, on isolated guinea pig ventricular myocytes under normoxic conditions and simulated ischemia and reperfusion. Currents and contractions were recorded with voltage clamp and a video
Publikováno v:
Cardiovascular Research. 54:601-610
Beneficial effects of n −3 polyunsaturated fatty acids in Ca2+ overload have been attributed to blockade of L-type Ca2+ current ( I Ca-L). However, cardiac contractions may be maintained despite block of I Ca-L. Objective: This study investigates t
Autor:
Susan E. Howlett, Gregory R. Ferrier
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 280:H1928-H1944
The steps that couple depolarization of the cardiac cell membrane to initiation of contraction remain controversial. Depolarization triggers a rise in intracellular free Ca2+which activates contractile myofilaments. Most of this Ca2+is released from
Publikováno v:
Europe PubMed Central
Control of contraction and relaxation by membrane potential was investigated in voltage-clamped guinea pig ventricular myocytes at 37°C. Depolarization initiated phasic contractions, followed by sustained contractions that relaxed with repolarizatio
Increased Expression of the Gene for α-Interferon-Inducible Protein in Cardiomyopathic Hamster Heart
Publikováno v:
Biochemical and Biophysical Research Communications. 267:103-108
Cardiomyopathic (CM) hamsters have a disruption in the δ-sarcoglycan gene which leads to progressive cardiac necrosis by 30 to 40 days of age, hypertrophy by 120 days, and heart failure by 250 days. We used differential display to detect other chang
Publikováno v:
Europe PubMed Central
We investigated excitation-contraction (EC) coupling in isolated ventricular myocytes from prehypertrophic cardiomyopathic (CM) hamster hearts. Conventional and voltage-clamp recordings were made with high-resistance microelectrodes, and cell shorten