Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Gregory R. Bowman"'
Autor:
Artur Meller, Michael Ward, Jonathan Borowsky, Meghana Kshirsagar, Jeffrey M. Lotthammer, Felipe Oviedo, Juan Lavista Ferres, Gregory R. Bowman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Cryptic pockets enable targeting of proteins currently considered undruggable because they lack pockets in their ground state structures. Here, the authors develop a graph neural network that accurately predicts cryptic pockets in static structures b
Externí odkaz:
https://doaj.org/article/41a3c6430fd3496cb5e06f23a4ce9bc3
Autor:
Zhou Huang, Hejun Liu, Jay Nix, Rui Xu, Catherine R. Knoverek, Gregory R. Bowman, Gaya K. Amarasinghe, L. David Sibley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Intrinsically disordered proteins (IDP) are pleotropic proteins with diverse functions. Here the authors show that an IDP, TgIST, from T. gondii blocks interferon-induced gene expression by binding to the STAT1 dimer interface and preventing the recr
Externí odkaz:
https://doaj.org/article/a6bd946cac384ca6aa1560990f2e0aa3
Autor:
Artur Meller, Saulo De Oliveira, Aram Davtyan, Tigran Abramyan, Gregory R. Bowman, Henry van den Bedem
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Virtual screening is a widely used tool for drug discovery, but its predictive power can vary dramatically depending on how much structural data is available. In the best case, crystal structures of a ligand-bound protein can help find more potent li
Externí odkaz:
https://doaj.org/article/b60074420ce54bbd8559ec679949561f
Autor:
Matthew A. Cruz, Thomas E. Frederick, Upasana L. Mallimadugula, Sukrit Singh, Neha Vithani, Maxwell I. Zimmerman, Justin R. Porter, Katelyn E. Moeder, Gaya K. Amarasinghe, Gregory R. Bowman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Many viral proteins are thought to be unlikely candidates for drug discovery as they lack obvious drug binding sites. Here, the authors use computational approaches followed by experimental validation to identify a cryptic pocket within the Ebola vir
Externí odkaz:
https://doaj.org/article/b1138d9e9bae403da917984ac9c6ee9b
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 5838-5846 (2022)
Filament formation by cytoskeletal proteins is critical to their involvement in myriad cellular processes. The bacterial actin homolog MreB, which is essential for cell-shape determination in many rod-shaped bacteria, has served as a model system for
Externí odkaz:
https://doaj.org/article/ced24bcd449d42f495fb58eda4ac1863
Autor:
Michael D. Ward, Maxwell I. Zimmerman, Artur Meller, Moses Chung, S. J. Swamidass, Gregory R. Bowman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Comparing and contrasting structural ensembles of different protein variants helps connect specific structural features to a protein’s biochemical properties. Here, the authors propose DiffNets, a self-supervised, deep learning method that streamli
Externí odkaz:
https://doaj.org/article/13c6be6650f24dc28b6a7660d1256cac
Autor:
Jasmine Cubuk, Jhullian J. Alston, J. Jeremías Incicco, Sukrit Singh, Melissa D. Stuchell-Brereton, Michael D. Ward, Maxwell I. Zimmerman, Neha Vithani, Daniel Griffith, Jason A. Wagoner, Gregory R. Bowman, Kathleen B. Hall, Andrea Soranno, Alex S. Holehouse
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
SARS-CoV-2 nucleocapsid (N) protein is responsible for viral genome packaging. Here the authors employ single-molecule spectroscopy with all-atom simulations to provide the molecular details of N protein and show that it undergoes phase separation wi
Externí odkaz:
https://doaj.org/article/dd6a306bbe1846f28cbf4f152c659197
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Externí odkaz:
https://doaj.org/article/df5b4b4f33f4417691232cfc39be9645
Autor:
Wenjie Wang, Woo-Jin Shin, Bojie Zhang, Younho Choi, Ji-Seung Yoo, Maxwell I. Zimmerman, Thomas E. Frederick, Gregory R. Bowman, Michael L. Gross, Daisy W. Leung, Jae U. Jung, Gaya K. Amarasinghe
Publikováno v:
Cell Reports, Vol 30, Iss 1, Pp 153-163.e5 (2020)
Summary: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%–30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States. Together, SFTSV and HRTV are emerging segmented
Externí odkaz:
https://doaj.org/article/7cbd66fb560d401da468d805028c6853
Autor:
Maxwell I. Zimmerman, Kathryn M. Hart, Carrie A. Sibbald, Thomas E. Frederick, John R. Jimah, Catherine R. Knoverek, Niraj H. Tolia, Gregory R. Bowman
Publikováno v:
ACS Central Science, Vol 3, Iss 12, Pp 1311-1321 (2017)
Externí odkaz:
https://doaj.org/article/74ea6caeaaeb48979b0f3c73141052a4