Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Gregory R Keele"'
Autor:
Callan O'Connor, Gregory R Keele, Whitney Martin, Timothy Stodola, Daniel Gatti, Brian R Hoffman, Ron Korstanje, Gary A Churchill, Laura G Reinholdt
Publikováno v:
PLoS Genetics, Vol 20, Iss 4, p e1011248 (2024)
The health risks that arise from environmental exposures vary widely within and across human populations, and these differences are largely determined by genetic variation and gene-by-environment (gene-environment) interactions. However, risk assessm
Externí odkaz:
https://doaj.org/article/8001d05cf09240178e416101081e5df1
Autor:
Gregory R Keele
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 13, Iss 4 (2023)
AbstractMultiparental populations (MPPs) encompass greater genetic diversity than traditional experimental crosses of two inbred strains, enabling broader surveys of genetic variation underlying complex traits. Two such mouse MPPs are the Collaborati
Externí odkaz:
https://doaj.org/article/9fdc5a84c1bf487c956efe781d0b7038
Publikováno v:
PLoS Genetics, Vol 18, Iss 5, p e1010184 (2022)
Genetic studies often seek to establish a causal chain of events originating from genetic variation through to molecular and clinical phenotypes. When multiple phenotypes share a common genetic association, one phenotype may act as an intermediate fo
Externí odkaz:
https://doaj.org/article/72d0915fdb7d445a88a4acb36baf78d9
Autor:
Jelena Čuklina, Chloe H Lee, Evan G Williams, Tatjana Sajic, Ben C Collins, María Rodríguez Martínez, Varun S Sharma, Fabian Wendt, Sandra Goetze, Gregory R Keele, Bernd Wollscheid, Ruedi Aebersold, Patrick G A Pedrioli
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 8, Pp n/a-n/a (2021)
Abstract Advancements in mass spectrometry‐based proteomics have enabled experiments encompassing hundreds of samples. While these large sample sets deliver much‐needed statistical power, handling them introduces technical variability known as ba
Externí odkaz:
https://doaj.org/article/19902b50778d4e318c792e04483c0f07
Autor:
Gregory R Keele, Bryan C Quach, Jennifer W Israel, Grace A Chappell, Lauren Lewis, Alexias Safi, Jeremy M Simon, Paul Cotney, Gregory E Crawford, William Valdar, Ivan Rusyn, Terrence S Furey
Publikováno v:
PLoS Genetics, Vol 16, Iss 1, p e1008537 (2020)
Gene transcription profiles across tissues are largely defined by the activity of regulatory elements, most of which correspond to regions of accessible chromatin. Regulatory element activity is in turn modulated by genetic variation, resulting in va
Externí odkaz:
https://doaj.org/article/d11b2185ebde45e2b7141adfb9f116db
Autor:
Ethan M Lange, Anna M Johnson, Yunfei Wang, Kimberly A Zuhlke, Yurong Lu, Jessica V Ribado, Gregory R Keele, Jin Li, Qing Duan, Ge Li, Zhengrong Gao, Yun Li, Jianfeng Xu, William B Isaacs, Siqun Zheng, Kathleen A Cooney
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93436 (2014)
Prostate cancer is the most common non-skin cancer and the second leading cause of cancer related mortality for men in the United States. There is strong empirical and epidemiological evidence supporting a stronger role of genetics in early-onset pro
Externí odkaz:
https://doaj.org/article/98d573dd13d54d61b2bd7817179e867d
Autor:
Selcan Aydin, Duy T. Pham, Tian Zhang, Gregory R. Keele, Daniel A. Skelly, Joao A. Paulo, Matthew Pankratz, Ted Choi, Steven P. Gygi, Laura G. Reinholdt, Christopher L. Baker, Gary A. Churchill, Steven C. Munger
Publikováno v:
Cell Genom
Genetic background drives phenotypic variability in pluripotent stem cells (PSCs). Most studies to date have used transcript abundance as the primary molecular readout of cell state in PSCs. We performed a comprehensive proteogenomics analysis of 190
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b65234a40df372a3c42124ce07488ba0
https://europepmc.org/articles/PMC10112288/
https://europepmc.org/articles/PMC10112288/
Publikováno v:
GENETICS. 224
Mediation analysis is used in genetic mapping studies to identify candidate gene mediators of quantitative trait loci (QTL). We consider genetic mediation analysis of triplets—sets of three variables consisting of a target trait, the genotype at a
Autor:
Qing Yu, Xinyue Liu, Mark P. Keller, Jose Navarrete-Perea, Tian Zhang, Sipei Fu, Laura P. Vaites, Steven R. Shuken, Ernst Schmid, Gregory R. Keele, Jiaming Li, Edward L. Huttlin, Edrees H. Rashan, Judith Simcox, Gary A. Churchill, Devin K. Schweppe, Alan D. Attie, Joao A. Paulo, Steven P. Gygi
Publikováno v:
Nature Communications. 14
Targeted proteomics enables hypothesis-driven research by measuring the cellular expression of protein cohorts related by function, disease, or class after perturbation. Here, we present a pathway-centric approach and an assay builder resource for ta
Autor:
Leah C Solberg Woods, Richard Mott, William Valdar, Gregory Hawkins, Chia-Chi Chuang Key, Aron M Geurts, Neeraj K Sharma, Jason Klotz, Michael Grzybowski, Bailey McDonald, Alexandria M Szalanczy, Swapan K. Das, Ann Craddock, Michael Tschannen, Osborne Seshie, Katie Holl, Gregory R Keele, Wesley L. Crouse, Thu H Lee
Despite the successes of human genome-wide association studies, the causal genes underlying most metabolic traits remain unclear. We used outbred heterogeneous stock (HS) rats, coupled with expression data and mediation analysis, to identify quantita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3243e4db00eb3f5069f282c6abd245da
https://doi.org/10.2337/figshare.21295908.v1
https://doi.org/10.2337/figshare.21295908.v1