Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Gregory R J, Thatcher"'
Autor:
Deebika Balu, Ana C. Valencia-Olvera, Ashwini Deshpande, Saharsh Narayanam, Sravya Konasani, Shreya Pattisapu, Jason M. York, Gregory R. J. Thatcher, Mary Jo LaDu, Leon M. Tai
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Increasing evidence suggests that female individuals have a higher Alzheimer’s disease (AD) risk associated with post-menopausal loss of circulating estradiol (E2). However, clinical data are conflicting on whether E2 lowers AD risk. One potential
Externí odkaz:
https://doaj.org/article/c8dfbdee1ee04ce49baa722ee97324c7
Autor:
Valentina Z. Petukhova, Sammy Y. Aboagye, Matteo Ardini, Rachel P. Lullo, Francesca Fata, Margaret E. Byrne, Federica Gabriele, Lucy M. Martin, Luke N. M. Harding, Vamshikrishna Gone, Bikash Dangi, Daniel D. Lantvit, Dejan Nikolic, Rodolfo Ippoliti, Grégory Effantin, Wai Li Ling, Jeremy J. Johnson, Gregory R. J. Thatcher, Francesco Angelucci, David L. Williams, Pavel A. Petukhov
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Only praziquantel is available for treating schistosomiasis, a disease affecting more than 200 million people. Praziquantel-resistant worms have been selected for in the lab and low cure rates from mass drug administration programs suggest t
Externí odkaz:
https://doaj.org/article/be068dfc60f64b079ddfa79996f6b0e8
Autor:
Sarah B. Scheinman, Steve Zaldua, Adedoyin Dada, Kateryna Krochmaliuk, Katherine Dye, Felecia M. Marottoli, Gregory R. J. Thatcher, Leon M. Tai
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Evidence suggests that angiotensin receptor blockers (ARBs) could be beneficial for Alzheimer’s disease (AD) patients independent of any effects on hypertension. However, studies in rodent models directly testing the activity of ARB treatment on be
Externí odkaz:
https://doaj.org/article/fb542f03343d4d58bac9899b5cd12600
Autor:
Adam Schafer, Rui Xiong, Laura Cooper, Raghad Nowar, Hyun Lee, Yangfeng Li, Benjamin E Ramirez, Norton P Peet, Michael Caffrey, Gregory R J Thatcher, Erica Ollmann Saphire, Han Cheng, Lijun Rong
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009312 (2021)
Many small molecules have been identified as entry inhibitors of filoviruses. However, a lack of understanding of the mechanism of action for these molecules limits further their development as anti-filoviral agents. Here we provide evidence that tor
Externí odkaz:
https://doaj.org/article/513584dcab26402ea212101359422d10
Autor:
Rakesh Sathish Nair, Sandeep Kumar, Subhasis Das, Sunil Kumar Singh, Piush Srivastava, Gautam Sondarva, Arundhati Rao, Subhash C. Sinha, Rui Xiong, Laura Bloem, Kent Hoskins, Gregory R. J. Thatcher, Basabi Rana, Ajay Rana
Publikováno v:
Oncogene. 42:1132-1143
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49a06d9b1cba15e808eb6f9799a36772
https://doi.org/10.1038/s41388-023-02633-6
https://doi.org/10.1038/s41388-023-02633-6
Autor:
Kiira M. Ratia, Zhengnan Shen, Jesse Gordon-Blake, Hyun Lee, Megan S. Laham, Isabella S. Krider, Nicholas Christie, Martha Ackerman-Berrier, Christopher Penton, Natalie G. Knowles, Soumya Reddy Musku, Jiqiang Fu, Ganga Reddy Velma, Rui Xiong, Gregory R. J. Thatcher
Publikováno v:
Biochemistry. 62:923-933
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5010c3a8da6aacac3d71200ed29f01b
https://doi.org/10.1021/acs.biochem.2c00655
https://doi.org/10.1021/acs.biochem.2c00655
Autor:
Andrey A. Poloznikov, Sergey V. Nikulin, Dmitry M. Hushpulian, Anna Yu. Khristichenko, Andrey I. Osipyants, Andrey F. Asachenko, Olga V. Shurupova, Svyatoslav S. Savin, Sue H. Lee, Irina N. Gaisina, Gregory R. J. Thatcher, Anthony Narciso, Eric P. Chang, Sergey V. Kazakov, Nancy Krucher, Vladimir I. Tishkov, Bobby Thomas, Irina G. Gazaryan
Publikováno v:
Antioxidants, Vol 11, Iss 2, p 220 (2022)
To evaluate the differences in action of commercially available 2-oxoglutarate mimetics and “branched-tail” oxyquinoline inhibitors of hypoxia-inducible factor prolyl hydroxylase (HIF PHD), the inhibitors’ IC50 values in the activation of HIF1
Externí odkaz:
https://doaj.org/article/346dd9b0bc0241e5a107f57d17140f23
Autor:
Saad Alqarni, Laura Cooper, Jazmin Galvan Achi, Ryan Bott, Veeresh Kumar Sali, Andrew Brown, Bernard D. Santarsiero, Aleksej Krunic, Balaji Manicassamy, Norton P. Peet, Pin Zhang, Gregory R. J. Thatcher, Irina N. Gaisina, Lijun Rong, Terry W. Moore
Publikováno v:
Journal of Medicinal Chemistry. 65:14104-14120
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2419fd8cb167e8defe6024cc591faf50
https://doi.org/10.1021/acs.jmedchem.2c01329
https://doi.org/10.1021/acs.jmedchem.2c01329
Autor:
Ana C. Valencia-Olvera, Deebika Balu, Naomi Faulk, Aspasia Amiridis, Yueting Wang, Christine Pham, Eva Avila-Munoz, Jason M. York, Gregory R. J. Thatcher, Mary Jo LaDu
Publikováno v:
Neurotherapeutics.
APOE4, encoding apolipoprotein E4 (apoE4), is the greatest genetic risk factor for Alzheimer’s disease (AD), compared to the common APOE3. While the mechanism(s) underlying APOE4-induced AD risk remains unclear, increasing the lipidation of apoE4 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2d4cd00ed2bb97ca180cca42fc60b0d
https://doi.org/10.1007/s13311-023-01375-3
https://doi.org/10.1007/s13311-023-01375-3
Autor:
Hu Chen, Yunlong Lu, Rui Xiong, Carlo I. Rosales, Cassandre Coles, Kana Hamada, Nuria Asad, Gregory R. J. Thatcher, Amy W. Lasek
Publikováno v:
Alcoholism: Clinical and Experimental Research. 46:1313-1320
Greater circulating levels of the steroid hormone 17β-estradiol (E2) are associated with higher levels of binge drinking in women. In female mice, estrogen receptors in the ventral tegmental area, a dopaminergic region of the brain involved in the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162ecd33000b600985ebe3abd2cf9c24
https://doi.org/10.1111/acer.14874
https://doi.org/10.1111/acer.14874