Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Gregory R Hoffman"'
Autor:
Rowena DeJesus, Francesca Moretti, Gregory McAllister, Zuncai Wang, Phil Bergman, Shanming Liu, Elizabeth Frias, John Alford, John S Reece-Hoyes, Alicia Lindeman, Jennifer Kelliher, Carsten Russ, Judith Knehr, Walter Carbone, Martin Beibel, Guglielmo Roma, Aylwin Ng, John A Tallarico, Jeffery A Porter, Ramnik J Xavier, Craig Mickanin, Leon O Murphy, Gregory R Hoffman, Beat Nyfeler
Publikováno v:
eLife, Vol 5 (2016)
SQSTM1 is an adaptor protein that integrates multiple cellular signaling pathways and whose expression is tightly regulated at the transcriptional and post-translational level. Here, we describe a forward genetic screening paradigm exploiting CRISPR-
Externí odkaz:
https://doaj.org/article/740ed0340cbe47708079afcf989db0dd
Autor:
Carlos G. Sanchez, Christopher M. Acker, Audrey Gray, Malini Varadarajan, Cheng Song, Nadire R. Cochran, Steven Paula, Alicia Lindeman, Shaojian An, Gregory McAllister, John Alford, John Reece-Hoyes, Carsten Russ, Lucas Craig, Ketthsy Capre, Christian Doherty, Gregory R. Hoffman, Sarah J. Luchansky, Manuela Polydoro, Ricardo Dolmetsch, Fiona Elwood
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Using an unbiased genome-wide CRISPR screen approach, Sanchez et al. identified modulators of endogenous tau protein. This study suggests that chromatin modifiers, neddylation, ubiquitination, and the mTOR pathways regulate overall levels of tau prot
Externí odkaz:
https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2
Autor:
Robert J. Ihry, Max R. Salick, Daniel J. Ho, Marie Sondey, Sravya Kommineni, Steven Paula, Joe Raymond, Beata Henry, Elizabeth Frias, Qiong Wang, Kathleen A. Worringer, Chaoyang Ye, Carsten Russ, John S. Reece-Hoyes, Robert C. Altshuler, Ranjit Randhawa, Zinger Yang, Gregory McAllister, Gregory R. Hoffman, Ricardo Dolmetsch, Ajamete Kaykas
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 616-630.e6 (2019)
Summary: Human pluripotent stem cells (hPSCs) generate a variety of disease-relevant cells that can be used to improve the translation of preclinical research. Despite the potential of hPSCs, their use for genetic screening has been limited by techni
Externí odkaz:
https://doaj.org/article/39ad2f3ea8e94904a721c8785edecb36
Autor:
Fiona Elwood, John Alford, Carsten Russ, Christopher Acker, Audrey Gray, John S. Reece-Hoyes, Carlos G Sanchez, Sarah J. Luchansky, Christian Doherty, Lucas Craig, Gregory McAllister, Steven Paula, Ricardo E. Dolmetsch, Shaojian An, Cheng Song, Alicia Lindeman, Malini Varadarajan, Nadire Cochran, Manuela Polydoro, Ketthsy Capre, Gregory R. Hoffman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
Communications Biology
Aggregates of hyperphosphorylated tau protein are a pathological hallmark of more than 20 distinct neurodegenerative diseases, including Alzheimer’s disease, progressive supranuclear palsy, and frontotemporal dementia. While the exact mechanism of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a06bbe1da74cbde2af5f7fb1d3fc80e
https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2
https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2
Autor:
Xinming Cai, Zinger Yang, John S. Reece-Hoyes, Edmund Harrington, John Alford, Tim Schuhmann, Luis Llamas, Rob Maher, Alicia Lindeman, Stephen M. Canham, Irina Alimov, Nadire Cochran, Carsten Russ, Suchithra Menon, Gregory R. Hoffman, Qiong Wang, John Concannon
Publikováno v:
Journal of Biological Chemistry. 294:3359-3366
Bile acids are critical metabolites in the gastrointestinal tract and contribute to maintaining intestinal immune homeostasis through cross-talk with the gut microbiota. The conversion of bile acids by the gut microbiome is now recognized as a factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276c48c6e9a8f74f5d3be2581e7eed33
https://doi.org/10.1074/jbc.ra118.005103
https://doi.org/10.1074/jbc.ra118.005103
Autor:
Marek J. Kobylarz, Leon Murphy, William E. Dowdle, Rowena DeJesus, Jonathan M. Goodwin, Alicia Lindeman, Beat Nyfeler, Gregory McAllister, Zuncai Wang, Gregory R. Hoffman, Ramnik J. Xavier, Philip Bergman
Publikováno v:
Cell Reports, Vol 20, Iss 10, Pp 2341-2356 (2017)
Iron is vital for many homeostatic processes and its liberation from ferritin nanocages occurs in the lysosome. Studies indicate that ferritin and its binding partner nuclear receptor coactivator-4 (NCOA4) are targeted to lysosomes by a form of selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef54941eaa793724f625867ca74b743
https://doi.org/10.1016/j.celrep.2017.08.034
https://doi.org/10.1016/j.celrep.2017.08.034
Autor:
Meghan Holdorf, Nadire Cochran, Lili Xie, Paul Feucht, Scott Clarkson, Kyoko Uehara, Gregory R. Hoffman, Darlene Chen, Don Ganem, Frederic Sigoillot, Carsten Russ, Anastasia Hyrina, Alicia Lindeman, Christopher T. Jones
GRAPHICAL ABSTRACTSUMMARYA hallmark of chronic hepatitis B virus (CHB) infection is the presence of high circulating levels of non-infectious small lipid HBV surface antigen (HBsAg) vesicles. Although rare, sustained HBsAg loss is the idealized endpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260bc9cfe9475b4cb2496f1e7d32b1ec
Autor:
Frederic Sigoillot, Lili Xie, Don Ganem, Kyoko Uehara, Scott Clarkson, Carsten Russ, Nadire Cochran, Tiffany Tsang, Gregory R. Hoffman, Darlene Chen, Meghan Holdorf, Paul Feucht, Anastasia Hyrina, Christopher T. Jones, Alicia Lindeman
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 2970-2978.e6 (2019)
Summary: A hallmark of chronic hepatitis B (CHB) virus infection is the presence of high circulating levels of non-infectious small lipid HBV surface antigen (HBsAg) vesicles. Although rare, sustained HBsAg loss is the idealized endpoint of any CHB t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437c578ad7f817c270632ea67c9e190a
https://pubmed.ncbi.nlm.nih.gov/31801065
https://pubmed.ncbi.nlm.nih.gov/31801065
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1888
Chemogenomic profiling is a powerful and unbiased approach to elucidate pharmacological targets and the mechanism of bioactive compounds. It is based on identifying cellular hypersensitivity and resistance caused by individual gene modulations with g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a4aa8b897d1354bb49d873336956a4a
https://pubmed.ncbi.nlm.nih.gov/30519946
https://pubmed.ncbi.nlm.nih.gov/30519946
Publikováno v:
Methods in Molecular Biology ISBN: 9781493988907
Chemogenomic profiling is a powerful and unbiased approach to elucidate pharmacological targets and the mechanism of bioactive compounds. It is based on identifying cellular hypersensitivity and resistance caused by individual gene modulations with g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e303b9ebf5fbf97ac96dafa605b12af
https://doi.org/10.1007/978-1-4939-8891-4_9
https://doi.org/10.1007/978-1-4939-8891-4_9