Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Gregory R Bowman"'
Autor:
Artur Meller, Jeffrey M Lotthammer, Louis G Smith, Borna Novak, Lindsey A Lee, Catherine C Kuhn, Lina Greenberg, Leslie A Leinwand, Michael J Greenberg, Gregory R Bowman
Publikováno v:
eLife, Vol 12 (2023)
The design of compounds that can discriminate between closely related target proteins remains a central challenge in drug discovery. Specific therapeutics targeting the highly conserved myosin motor family are urgently needed as mutations in at least
Externí odkaz:
https://doaj.org/article/376094e3254c440f9fdb0628df390ca2
Publikováno v:
eLife, Vol 9 (2020)
Myosin motor domains perform an extraordinary diversity of biological functions despite sharing a common mechanochemical cycle. Motors are adapted to their function, in part, by tuning the thermodynamics and kinetics of steps in this cycle. However,
Externí odkaz:
https://doaj.org/article/a55697cfd1e6486e9b1c8264c308fb3b
Publikováno v:
eLife, Vol 7 (2018)
Activation of heterotrimeric G proteins is a key step in many signaling cascades. However, a complete mechanism for this process, which requires allosteric communication between binding sites that are ~30 Å apart, remains elusive. We construct an at
Externí odkaz:
https://doaj.org/article/b702c1ac42d1476ca82226bd85919647
Autor:
Angela M Halstead, Chiraag D Kapadia, Jennifer Bolzenius, Clarence E Chu, Andrew Schriefer, Lukas D Wartman, Gregory R Bowman, Vivek K Arora
Publikováno v:
eLife, Vol 6 (2017)
RXRA regulates transcription as part of a heterodimer with 14 other nuclear receptors, including the peroxisome proliferator-activated receptors (PPARs). Analysis from TCGA raised the possibility that hyperactive PPAR signaling, either due to PPAR ga
Externí odkaz:
https://doaj.org/article/5e55d396266f41bb8f7c93bd06a58047
Autor:
Kathryn M Hart, Katelyn E Moeder, Chris M W Ho, Maxwell I Zimmerman, Thomas E Frederick, Gregory R Bowman
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178678 (2017)
Allosteric drugs, which bind to proteins in regions other than their main ligand-binding or active sites, make it possible to target proteins considered "undruggable" and to develop new therapies that circumvent existing resistance. Despite growing i
Externí odkaz:
https://doaj.org/article/2e2ae9d93da7443fa8dfefba3b8eff92
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 5, p e1002054 (2011)
Molecular recognition is determined by the structure and dynamics of both a protein and its ligand, but it is difficult to directly assess the role of each of these players. In this study, we use Markov State Models (MSMs) built from atomistic simula
Externí odkaz:
https://doaj.org/article/e02c0f6603d448b488d28d217326a5fc
Autor:
Gregory R Bowman, Vijay S Pande
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5840 (2009)
Here we continue our efforts to use methods developed in the folding mechanism community to both better understand and improve structure prediction. Our previous work demonstrated that Rosetta's coarse-grained potentials may actually impede accurate
Externí odkaz:
https://doaj.org/article/c2918a18093441f9b06cf88ed50d6f03
Autor:
Gregory R. Bowman, Stephen J. Cox, Christoph Dellago, Kateri H. DuBay, Joel D. Eaves, Daniel A. Fletcher, Layne B. Frechette, Michael Grünwald, Katherine Klymko, JiYeon Ku, Ahmad K. Omar, Eran Rabani, David R. Reichman, Julia R. Rogers, Andreana M. Rosnik, Grant M. Rotskoff, Anna R. Schneider, Nadine Schwierz, David A. Sivak, Suriyanarayanan Vaikuntanathan, Stephen Whitelam, Asaph Widmer-Cooper
Publikováno v:
Annual review of physical chemistry, vol 74, iss 1
Phillip L. Geissler made important contributions to the statistical mechanics of biological polymers, heterogeneous materials, and chemical dynamics in aqueous environments. He devised analytical and computational methods that revealed the underlying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025949652cc1fbed5379b498a4b5e986
https://www.repository.cam.ac.uk/handle/1810/347057
https://www.repository.cam.ac.uk/handle/1810/347057
Publikováno v:
Biophysical Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::562643c41b23d31cc1a749a72f3c67cc
https://doi.org/10.1016/j.bpj.2023.03.028
https://doi.org/10.1016/j.bpj.2023.03.028
Publikováno v:
Computational and Structural Biotechnology Journal. 20:5838-5846
Filament formation by cytoskeletal proteins is critical to their involvement in myriad cellular processes. The bacterial actin homolog MreB, which is essential for cell-shape determination in many rod-shaped bacteria, has served as a model system for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b7707a45eb058af8ba4bf686d4b54a
https://doi.org/10.1016/j.csbj.2022.10.008
https://doi.org/10.1016/j.csbj.2022.10.008